Journal
CANCER AND METASTASIS REVIEWS
Volume 34, Issue 4, Pages 619-633Publisher
SPRINGER
DOI: 10.1007/s10555-015-9585-x
Keywords
Cell movement; Lipid rafts; Tetraspanin; Tumor initiation; Tumor metastasis
Categories
Funding
- NIH [CA096991, 1U54GM104938]
- AHA [13GRNT17040028]
- OCAST [HR13-207]
Ask authors/readers for more resources
Tetraspanin CD82 suppresses the progression and metastasis of a wide range of solid malignant tumors. However, its roles in tumorigenesis and hematopoietic malignancy remain unclear. Ubiquitously expressed CD82 restrains cell migration and cell invasion by modulating both cell-matrix and cell-cell adhesiveness and confining outside-in pro-motility signaling. This restraint at least contributes to, if not determines, the metastasis-suppressive activity and, also likely, the physiological functions of CD82. As a modulator of cell membrane heterogeneity, CD82 alters microdomains, trafficking, and topography of the membrane by changing the membrane molecular landscape. The functional activities of membrane molecules and the cytoskeletal interaction of the cell membrane are subsequently altered, followed by changes in cellular functions. Given its pathological and physiological importance, CD82 is a promising candidate for clinically predicting and blocking tumor progression and metastasis and also an emerging model protein for mechanistically understanding cell membrane organization and heterogeneity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available