Germinal center kinases in immune regulation

Etk/BMX, a Btk Family Tyrosine Kinase, and Mal Contribute to the Cross-Talk between MyD88 and FAK Pathways

(2014) N. Semaan et al.   JOURNAL OF IMMUNOLOGY

Ezrin and Moesin Function Together to Promote T Cell Activation

(2014) M. H. Shaffer et al.   JOURNAL OF IMMUNOLOGY

Interaction of dengue virus nonstructural protein 5 with Daxx modulates RANTES production

(2012) Sasiprapa Khunchai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

(2012) Stephen J. Fuller et al.   BIOCHEMICAL JOURNAL

The phenotype of human STK4 deficiency

(2012) H. Abdollahpour et al.   BLOOD

Focal Adhesion Kinase Is a Component of Antiviral RIG-I-like Receptor Signaling

(2012) Rebecca A. Bozym et al.   Cell Host & Microbe

PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress

(2012) Heyu Zhang   Frontiers in Bioscience-Landmark

Misshapen-like kinase 1 (MINK1) Is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis

(2012) Toshinori Hyodo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimerization and Cytoplasmic Localization Regulate Hippo Kinase Signaling Activity in Organ Size Control

(2012) Yunyun Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Relevance of Antioxid/Redox Genes; Learning from Genetically Modified Animals Guest Editor: Junichi Fujii Novel roles of peroxiredoxins in inflammation, cancer and innate immunity

(2012) Tetsuro Ishii et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes

(2012) Fan Mou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMP-Activated Kinase Restricts Rift Valley Fever Virus Infection by Inhibiting Fatty Acid Synthesis

(2012) Theresa S. Moser et al.   PLoS Pathogens

Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins

(2011) Zenon Grabarek   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules

(2011) S. Kliche et al.   BLOOD

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

(2011) N. T. Nehme et al.   BLOOD

Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II

(2011) Kathryn A. Skelding et al.   CELL CYCLE

EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and function

(2011) Abigail Clements et al.   CELLULAR MICROBIOLOGY

Ezrin, Radixin and Moesin: key regulators of membrane–cortex interactions and signaling

(2011) Amanda L Neisch et al.   CURRENT OPINION IN CELL BIOLOGY

Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters

(2011) Annie Mercier-Zuber et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection

(2011) Yonghao Cao et al.   EMBO JOURNAL

Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling

(2011) Hee Jae Yun et al.   EMBO JOURNAL

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

(2011) Beatrice M Filippi et al.   EMBO JOURNAL

CCM3/PDCD10 Heterodimerizes with Germinal Center Kinase III (GCKIII) Proteins Using a Mechanism Analogous to CCM3 Homodimerization

(2011) Derek F. Ceccarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of Core STRIPAK Proteins

(2011) Michelle J. Kean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus Type 5 Early Region 1B 55K Oncoprotein-Dependent Degradation of Cellular Factor Daxx Is Required for Efficient Transformation of Primary Rodent Cells

(2011) S. Schreiner et al.   JOURNAL OF VIROLOGY

In vivo analysis of protein sumoylation induced by a viral protein: Detection of HCMV pp71-induced Daxx sumoylation

(2011) Jiwon Hwang et al.   METHODS

FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis

(2011) Fang Liu et al.   MOLECULAR BIOLOGY REPORTS

The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

(2011) Huai-Chia Chuang et al.   NATURE IMMUNOLOGY

Regulation of mitosis and taxane response by Daxx and Rassf1

(2011) S Giovinazzi et al.   ONCOGENE

Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis

(2011) A Morinaka et al.   ONCOGENE

Emerging role for ERM proteins in cell adhesion and migration

(2011) Monique Arpin et al.   Cell Adhesion & Migration

EBV Tegument Protein BNRF1 Disrupts DAXX-ATRX to Activate Viral Early Gene Transcription

(2011) Kevin Tsai et al.   PLoS Pathogens

Programmed cell death-10 enhances proliferation and protects malignant T cells from apoptosis

(2010) BRITT LAUENBORG et al.   APMIS

Reelin and Stk25 Have Opposing Roles in Neuronal Polarization and Dendritic Golgi Deployment

(2010) Tohru Matsuki et al.   CELL

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

(2010) C. M. Contreras et al.   Disease Models & Mechanisms

Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse

(2010) Rémi Lasserre et al.   EMBO JOURNAL

HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion

(2010) Irene M. Patzak et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

(2010) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

(2010) M. Fidalgo et al.   JOURNAL OF CELL SCIENCE

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

Proteasome-Dependent Degradation of Daxx by the Viral E1B-55K Protein in Human Adenovirus-Infected Cells

(2010) S. Schreiner et al.   JOURNAL OF VIROLOGY

AID-Induced Genotoxic Stress Promotes B Cell Differentiation in the Germinal Center via ATM and LKB1 Signaling

(2010) Mara H. Sherman et al.   MOLECULAR CELL

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

(2010) Paulo S. Ribeiro et al.   MOLECULAR CELL

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HPK1 Associates with SKAP-HOM to Negatively Regulate Rap1-Mediated B-Lymphocyte Adhesion

(2010) Sebastian Königsberger et al.   PLoS One

The adaptor protein EBP50 is important for localization of the protein kinase A–Ezrin complex in T-cells and the immunomodulating effect of cAMP

(2009) Anne Jorunn Stokka et al.   BIOCHEMICAL JOURNAL

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

(2009) Yonghao Cao et al.   CELL RESEARCH

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

(2009) Koko Katagiri et al.   EMBO JOURNAL

Calmodulin-mediated regulation of the epidermal growth factor receptor

(2009) Pablo Sánchez-González et al.   FEBS Journal

A Cell-Intrinsic Role for Mst1 in Regulating Thymocyte Egress

(2009) Y. Dong et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Protein pp71 Induces Daxx SUMOylation

(2009) J. Hwang et al.   JOURNAL OF VIROLOGY

The Ldb1 and Ldb2 Transcriptional Cofactors Interact with the Ste20-like Kinase SLK and Regulate Cell Migration

(2009) Chris J. Storbeck et al.   MOLECULAR BIOLOGY OF THE CELL

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility

(2009) K Roovers et al.   ONCOGENE

Mst1-FoxO Signaling Protects Naïve T Lymphocytes from Cellular Oxidative Stress in Mice

(2009) Juhyun Choi et al.   PLoS One

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38

(2009) J. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of CARMA1 by HPK1 is critical for NF- B activation in T cells

(2009) D. Brenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of domain-swapped STE20 OSR1 kinase domain

(2009) Seung-Jae Lee et al.   PROTEIN SCIENCE

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis

(2009) Janjuree Netsawang et al.   VIRUS RESEARCH

Daxx interacts with HIV-1 integrase and inhibits lentiviral gene expression

(2008) Lu Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

(2008) Eric Delpire et al.   BIOCHEMICAL JOURNAL

Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily

(2008) Jae J. Song et al.   CELLULAR SIGNALLING

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

FAK/src-Family Dependent Activation of the Ste20-Like Kinase SLK Is Required for Microtubule-Dependent Focal Adhesion Turnover and Cell Migration

(2008) Simona Wagner et al.   PLoS One

The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells

(2008) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the OSR1 kinase, a hypertension drug target

(2008) Fabrizio Villa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Basis for the Interaction between Focal Adhesion Kinase and CD4

(2007) Marie-Line Garron et al.   JOURNAL OF MOLECULAR BIOLOGY