Review
Cell Biology
Devesh C. Pant, Taras Y. Nazarko
Summary: Selective autophagy is the specific elimination of certain intracellular substrates through autophagic pathways. Zebrafish has been recognized as an excellent model for studying these processes, shedding light on the understanding of selective autophagy mechanisms.
Review
Biochemistry & Molecular Biology
Xinjie Guan, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Chengfu Su, Zhou Zhu, Jia Liu, Yuxuan Kan, King-Ho Cheung, Jiahong Lu, Jieqiong Tan, Min Li
Summary: Selective autophagy plays an important role in the pathogenesis of Alzheimer's disease, and regulating selective autophagy can be an effective strategy for controlling this pathological process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Omar Pena-Ramos, Lucia Chiao, Xianghua Liu, Xiaomeng Yu, Tianyou Yao, Henry He, Zheng Zhou
Summary: Autophagosomes play a crucial role in facilitating the degradation of apoptotic cells. They are recruited to the surfaces of phagosomes containing apoptotic cells and subsequently fuse with them, allowing the inner vesicle to enter the phagosomal lumen. Defects in autophagosome production result in significant defects in the degradation of apoptotic cells.
Editorial Material
Cell Biology
Zhihai Zhang, Daniel J. Klionsky
Summary: Protein aggregates are closely related to the pathogenesis of various human diseases. A recent study identified CCT2 as a specific aggrephagy receptor in mammals, which plays a role in the autophagic clearance of protein aggregates. This finding suggests that CCT2 could be an important target for treating protein aggregation-related diseases.
Article
Multidisciplinary Sciences
Tatsuya Shioda, Ittetsu Takahashi, Kensuke Ikenaka, Naonobu Fujita, Tomotake Kanki, Toshihiko Oka, Hideki Mochizuki, Adam Antebi, Tamotsu Yoshimori, Shuhei Nakamura
Summary: Accumulating evidence suggests that the molecular network involving neuronal MML-1 function is crucial for regulating systemic aging. This study demonstrates that MML-1 and its heterodimer partners play a primary role in neurons to extend longevity in germlineless animals, acting via downstream cascades that are distinct from HLH-30. The MML-1-GLT-5 axis in neurons is critical for maintaining proteostasis and reducing oxidative stress in long-lived animals through autophagy and peroxidase MLT-7, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Editorial Material
Cell Biology
Xinyu Ma, Min Zhang, Liang Ge
Summary: This recent study identifies CCT2 as a new type of aggrephagy receptor that specifically facilitates the autophagic clearance of solid protein aggregates. The findings also reveal the parallel action of multiple aggrephagy pathways in removing different types of protein aggregates.
Article
Cell Biology
Maomao Pu, Wenhui Zheng, Hongtao Zhang, Wei Wan, Chao Peng, Xuebo Chen, Xinchang Liu, Zizhen Xu, Tianhua Zhou, Qiming Sun, Dante Neculai, Wei Liu
Summary: This study found that lipophagy, the process of autophagosomes engulfing and degrading lipid droplets, is crucial for lipid and energy homeostasis. The lipid transfer protein ORP8 was found to be located on lipid droplets and mediates their encapsulation by autophagosomal membranes through direct interaction with LC3/GABARAPs. Phosphorylation of ORP8 by AMPK enhances its affinity for LC3/GABARAPs. Deletion or disruption of the ORP8-LC3/GABARAP interaction leads to lipid droplet accumulation and increased intracellular triglyceride.
Article
Cell Biology
Ankit Shroff, Taras Y. Nazarko
Summary: SQSTM1 is a well-established indicator of macroautophagic/autophagic flux and also plays a role in lipophagy by tagging, movement, and aggregation of lipid droplets. Although only one study reported all functions, other studies provide complementary evidence that suggests the role of SQSTM1 in lipid droplet autophagy is a common phenomenon in mammalian cells.
Review
Biochemistry & Molecular Biology
Anam Naseer, Snober Shabnam Mir, Krisztina Takacs-Vellai, Aamir Nazir
Summary: Age-associated neurodegenerative diseases are characterized by impaired protein clearance, leading to accumulation of unwanted proteins and subsequent neurodegeneration. Failure to regulate the autophagic machinery and the role of sirtuins are key factors contributing to this process. The model system C. elegans has been instrumental in studying the relationship between sirtuins, autophagy, and aging-related neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Md. Ataur Rahman, MD. Hasanur Rahman, A. N. M. Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhim
Summary: This article discusses the pathological features of Alzheimer's disease and the important role of autophagy pathway in prevention and treatment. By regulating autophagy, it is possible to effectively reduce the formation of protein aggregates associated with Alzheimer's disease, making it a potential therapeutic approach.
Article
Pharmacology & Pharmacy
Amir Hossein Faghfouri, Yaser Khajebishak, Laleh Payahoo, Elnaz Faghfuri, Mohammadreza Alivand
Summary: Autophagy pathways are involved in the pathogenesis of some obesity related health problems. PPAR-gamma as the main modulator of adipogenesis process can be effective in regulating obesity related phenotypes. The effects of PPAR-gamma and its agonists on autophagy modulation in obesity have been investigated in a limited number of studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Cell Biology
Feng Geng, Deliang Guo
Summary: SREBF1 plays a critical role in maintaining cholesterol homeostasis in tumor cells by regulating lipid synthesis, uptake, storage, and liberation to promote tumor growth.
Review
Pharmacology & Pharmacy
Abdul Alim Al-Bari, Yuko Ito, Paul G. Thomes, Manoj B. Menon, Marina Garcia-Macia, Raouf Fadel, Alfreda Stadlin, Nicholas Peake, MoezAlIslam Ezzat Faris, Nabil Eid, Daniel J. Klionsky
Summary: Autophagy is a conserved metabolic process that regulates cellular homeostasis by degrading dysfunctional constituents and invading pathogens. It selectively recycles specific organelles and eliminates liver diseases-related pathogens. Autophagy plays a crucial role in the pathogenesis and treatment of liver diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Jesse White, Sujit Suklabaidya, Mai Tram Vo, Young Bong Choi, Edward W. Harhaj
Summary: TAX1BP1 is a crucial autophagy receptor that plays a central role in host defense and regulating the immune system. In addition to its canonical functions, TAX1BP1 also influences the biogenesis and maturation of autophagosomes.
Article
Biology
Romane Leboutet, Celine Largeau, Leonie Mueller, Magali Prigent, Gregoire Quinet, Manuel S. Rodriguez, Marie-Helene Cuif, Thorsten Hoppe, Emmanuel Culetto, Christophe Lefebvre, Renaud Legouis, Hong Zhang
Summary: The proteins Atg8/LC3/GABARAP are crucial for various steps of autophagy, including initiation, cargo recognition and engulfment, vesicle closure and degradation. In C. elegans, the single homologs of LC3 and GABARAP, LGG-1 and LGG-2, play similar roles. Through mutagenesis experiments, we discovered that LGG-1 is essential for autophagy and development in C. elegans, but its functions can be fully achieved without its localization to the membrane.
Article
Cardiac & Cardiovascular Systems
Tommaso Poggioli, Ana Vujic, Peiguo Yang, Claudio Macias-Trevino, Aysu Uygur, Francesco S. Loffredo, James R. Pancoast, Miook Cho, Jill Goldstein, Rachel M. Tandias, Emilia Gonzalez, Ryan G. Walker, Thomas B. Thompson, Amy J. Wagers, Yick W. Fong, Richard T. Lee
CIRCULATION RESEARCH
(2016)
Article
Cell Biology
Long Lin, Yuping Li, Libo Yan, Gangming Zhang, Yu Zhao, Hong Zhang
Article
Cell Biology
Dan Wang, Lei Hou, Shuhei Nakamura, Ming Su, Fang Li, Weiyang Chen, Yizhen Yan, Christopher D. Green, Di Chen, Hong Zhang, Adam Antebi, Jing-Dong J. Han
Editorial Material
Cell Biology
Fan Wu, Peng Wang, Yuxian Shen, Nobuo N. Noda, Hong Zhang
Article
Microbiology
Qun Lu, Christine C. Yokoyama, Jesse W. Williams, Megan T. Baldridge, Xiaohua Jin, Brittany DesRochers, Traci Bricker, Craig B. Wilen, Juhi Bagaitkar, Ekaterina Loginicheva, Alexey Sergushichev, Darren Kreamalmeyer, Brian C. Keller, Yan Zhao, Amal Kambal, Douglas R. Green, Jennifer Martinez, Mary C. Dinauer, Michael J. Holtzman, Erika C. Crouch, Wandy Beatty, Adrianus C. M. Boon, Hong Zhang, Gwendalyn J. Randolph, Maxim N. Artyomov, Herbert W. Virgin
CELL HOST & MICROBE
(2016)
Editorial Material
Cell Biology
Yan G. Zhao, Hong Zhang
JOURNAL OF CELL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ke Zhang, J. Gavin Daigle, Kathleen M. Cunningham, Alyssa N. Coyne, Kai Ruan, Jonathan C. Grima, Kelly E. Bowen, Harsh Wadhwa, Peiguo Yang, Frank Rigo, J. Paul Taylor, Aaron D. Gitler, Jeffrey D. Rothstein, Thomas E. Lloyd
Article
Biology
Yubing Liu, Wei Zou, Peiguo Yang, Li Wang, Yan Ma, Hong Zhang, Xiaochen Wang
Article
Biology
Peipei Zhang, Baochang Fan, Peiguo Yang, Jamshid Temirov, James Messing, Hong Joo Kim, J. Paul Taylor
Article
Cell Biology
Cristina Batlle, Peiguo Yang, Maura Coughlin, James Messing, Mireia Pesarrodona, Elzbieta Szulc, Xavier Salvatella, Hong Joo Kim, J. Paul Taylor, Salvador Ventura
Article
Biochemistry & Molecular Biology
Peiguo Yang, Cecile Mathieu, Regina-Maria Kolaitis, Peipei Zhang, James Messing, Ugur Yurtsever, Zemin Yang, Jinjun Wu, Yuxin Li, Qingfei Pan, Jiyang Yu, Erik W. Martin, Tanja Mittag, Hong Joo Kim, J. Paul Taylor
Article
Biochemistry & Molecular Biology
Anna K. Lee, Jonathon Klein, Klementina Fon Tacer, Tessa Lord, Melissa J. Oatley, Jon M. Oatley, Shaina N. Porter, Shondra M. Pruett-Miller, Elena B. Tikhonova, Andrey L. Karamyshev, Yong-Dong Wang, Peiguo Yang, Ane Korff, Hong Joo Kim, J. Paul Taylor, Patrick Ryan Potts
Article
Cell Biology
Brian D. Freibaum, James Messing, Peiguo Yang, Hong Joo Kim, J. Paul Taylor
Summary: Liquid-liquid phase separation (LLPS) is a key mechanism in intracellular organization, especially in the assembly of various RNP granules. While simple in vitro systems have revealed important biophysical principles governing LLPS during granule assembly, visualizing RNP granules in cells presents challenges in studying their biophysical features and manipulating molecule concentrations. The introduction of a system that allows for high-fidelity reconstitution of stress granules and nucleoli components in mammalian cellular lysate bridges the gap between in vitro systems and live cells, providing opportunities for studying membraneless organelles and developing therapeutics targeting specific condensates.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qinqin Cui, Hongyun Bi, Zhanyun Lv, Qigui Wu, Jianfeng Hua, Bokai Gu, Chanjuan Huo, Mingmin Tang, Yanqin Chen, Chongjiu Chen, Sihan Chen, Xinrui Zhang, Zhangrui Wu, Zhengkai Lao, Nengyin Sheng, Chengyong Shen, Yongdeng Zhang, Zhi-Ying Wu, Zhigang Jin, Peiguo Yang, Huaqing Liu, Jinsong Li, Ge Bai
Summary: Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is caused by various mutated genes. This study reveals a stress-dependent molecular link across diverse CMT2 mutants and provides a conceptual framework for understanding genetic heterogeneity in light of environmental stress.
Review
Cell Biology
Hong Zhang, Jessica T. Chang, Bin Guo, Malene Hansen, Kailiang Jia, Attila L. Kovacs, Caroline Kumsta, Louis R. Lapierre, Renaud Legouis, Long Lin, Qun Lu, Alicia Melendez, Eyleen J. O'Rourke, Ken Sato, Miyuki Sato, Xiaochen Wang, Fan Wu