Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

(2012) Ethan Hoffmann et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

DNA damage as a molecular link in the pathogenesis of COPD in smokers

(2012) Kazutetsu Aoshiba et al.   EUROPEAN RESPIRATORY JOURNAL

Regulation of SIRT1 activity by genotoxic stress

(2012) J. Yuan et al.   GENES & DEVELOPMENT

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endothelial Progenitor Cells Enter the Aging Arena

(2012) K. Williamson et al.   Frontiers in Physiology

Telomere Dysfunction Causes Sustained Inflammation in Chronic Obstructive Pulmonary Disease

(2011) Valerie Amsellem et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of DNA damage in atherosclerosis—Bystander or participant?

(2011) Kelly Gray et al.   BIOCHEMICAL PHARMACOLOGY

Protective roles of SIRT1 in atherosclerosis

(2011) Sokrates Stein et al.   CELL CYCLE

Isolating and defining cells to engineer human blood vessels

(2011) P. J. Critser et al.   CELL PROLIFERATION

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

(2011) Cedric Blanpain et al.   Cell Stem Cell

SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis

(2011) Hidetaka Ota et al.   Journal of Atherosclerosis and Thrombosis

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

(2011) Chung-Lan Kao et al.   Journal of Atherosclerosis and Thrombosis

Manifestations and mechanisms of stem cell aging

(2011) Ling Liu et al.   JOURNAL OF CELL BIOLOGY

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

DNA damage response in adult stem cells: pathways and consequences

(2011) Pankaj K. Mandal et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease

(2011) Irfan Rahman et al.   PREVENTIVE MEDICINE

Impaired endothelial progenitor cell mobilization and colony-forming capacity in chronic obstructive pulmonary disease

(2011) TORU TAKAHASHI et al.   RESPIROLOGY

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

(2011) G. Caramori et al.   THORAX

Smoking Is Associated With Depletion of Circulating Endothelial Progenitor Cells and Elevated Pulmonary Artery Systolic Pressure in Patients With Coronary Artery Disease

(2010) Wen-Sheng Yue et al.   AMERICAN JOURNAL OF CARDIOLOGY

Endothelial von Willebrand factor regulates angiogenesis

(2010) R. D. Starke et al.   BLOOD

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

Chronic obstructive pulmonary disease and the risk of cardiovascular diseases

(2010) Cornelia Schneider et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Ataxia Telangiectasia Mutated (ATM)-mediated DNA Damage Response in Oxidative Stress-induced Vascular Endothelial Cell Senescence

(2010) Hong Zhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal Levels of Circulating Endothelial Progenitor Cells During Exacerbations of COPD

(2010) Ernest Sala et al.   LUNG

Circulating endothelial stem cells are not decreased in pulmonary emphysema or COPD

(2010) G. Caramori et al.   THORAX

Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease

(2009) Laurent Savale et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension

(2009) Mark Toshner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

(2009) Masayuki Orimo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)

(2009) William MacNee   BIOCHEMICAL SOCIETY TRANSACTIONS

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

TELOMERE LENGTH AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE: EVIDENCE OF ACCELERATED AGING

(2009) Tammy S. Y. Mui et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease

(2009) Takao Tsuji et al.   RESPIRATION

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds

(2008) Sabine Fuchs et al.   BIOMATERIALS

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

AsSIRTing the DNA damage response

(2008) Myriam Gorospe et al.   TRENDS IN CELL BIOLOGY