Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle

Phosphorylation of AKT: a Mutational Analysis.

(2015) Jonathan R. Hart et al.   Oncotarget

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis

(2013) R. Li et al.   CANCER RESEARCH

SUMO: A Multifaceted Modifier of Chromatin Structure and Function

(2013) Caelin Cubeñas-Potts et al.   DEVELOPMENTAL CELL

hnRNP U Enhances Caspase-9 Splicing and Is Modulated by AKT-dependent Phosphorylation of hnRNP L

(2013) Ngoc T. Vu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

MicroRNA-143 is a critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/cyclin D1 signaling

(2012) Vien Khach Lai et al.   CELL CYCLE

Akt is negatively regulated by the MULAN E3 ligase

(2012) Seunghee Bae et al.   CELL RESEARCH

Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform

(2012) André Apostolatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus

(2012) Zhihong Zhou et al.   MOLECULAR CELL

Regulation of the tumor suppressor PTEN by SUMO

(2012) J González-Santamaría et al.   Cell Death & Disease

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

Amiloride Modulates Alternative Splicing in Leukemic Cells and ResensitizesBcr-AblT315I Mutant Cells to Imatinib

(2011) Wen-Hsin Chang et al.   CANCER RESEARCH

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

(2011) Yuji Kubota et al.   NATURE CELL BIOLOGY

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a

(2010) J. C. Shultz et al.   CANCER RESEARCH

Genome-wide RNAi screen discovers functional coupling of alternative splicing and cell cycle control to apoptosis regulation

(2010) Qingqing Wang et al.   CELL CYCLE

Regulation of Akt signaling activation by ubiquitination

(2010) Wei-Lei Yang et al.   CELL CYCLE

Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway

(2010) Eric S. White et al.   EXPERIMENTAL CELL RESEARCH

The DNA Damage Response Pathway Regulates the Alternative Splicing of the Apoptotic MediatorBcl-x

(2010) Lulzim Shkreta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

(2010) Kiran Mahajan et al.   PLoS One

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

(2010) F. Pelisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Akt isoforms are present at distinct subcellular locations

(2009) Stacey A. Santi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

(2009) Futoshi Suizu et al.   DEVELOPMENTAL CELL

Current Perspectives on Akt Akt-ivation and Akt-ions

(2009) Ronald W. Matheny et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Detection of protein SUMOylation in vivo

(2009) Michael H Tatham et al.   Nature Protocols

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells

(2008) Shingo Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes

(2008) Lulzim Shkreta et al.   MOLECULAR CANCER THERAPEUTICS

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

The type I TGF-β receptor is covalently modified and regulated by sumoylation

(2008) Jong Seok Kang et al.   NATURE CELL BIOLOGY