On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: A Brownian dynamics study

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors

(2015) Asfar S. Azmi et al.   Oncotarget

The RP-Mdm2-p53 Pathway and Tumorigenesis

(2015) Paula L. Miliani de Marval et al.   Oncotarget

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

(2014) Grzegorz Popowicz et al.   CELL CYCLE

p53 regulation: Teamwork between RING domains of Mdm2 and MdmX

(2012) Xinjiang Wang   CELL CYCLE

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding

(2012) Shubhra Ghosh Dastidar et al.   CELL CYCLE

Length matters

(2012) Masha V. Poyurovsky   CELL CYCLE

Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

(2012) Pavlina Dolezelova et al.   CELL CYCLE

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

(2011) Michael M. Madden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanism-specific signatures for small-molecule p53 activators

(2011) Ingeborg M.M. van Leeuwen et al.   CELL CYCLE

Recent Advances in the Therapeutic Perspectives of Nutlin-3

(2011) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

Characterization of the Ligand Receptor Encounter Complex and Its Potential for in Silico Kinetics-Based Drug Development

(2011) Karim M. ElSawy et al.   Journal of Chemical Theory and Computation

How Does a Drug Molecule Find Its Target Binding Site?

(2011) Yibing Shan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Free Energy Landscape of Small Molecule Unbinding

(2011) Danzhi Huang et al.   PLoS Computational Biology

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

(2010) I Goldstein et al.   CANCER GENE THERAPY

The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides

(2010) Christopher John Brown et al.   CELL CYCLE

Differential binding of p53 and nutlin to MDM2 and MDMX: Computational studies

(2010) Thomas Leonard Joseph et al.   CELL CYCLE

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

(2010) Robert A Copeland   Expert Opinion on Drug Discovery

A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis

(2010) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Reactivation of p53: from peptides to small molecules

(2010) Christopher J. Brown et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Predicted Functions of MdmX in Fine-Tuning the Response of p53 to DNA Damage

(2010) Sohyoung Kim et al.   PLoS Computational Biology

Quantifying Biological Activity in Chemical Terms: A Pharmacology Primer To Describe Drug Effect

(2009) Terry Kenakin   ACS Chemical Biology

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

(2009) Shubhra Dastidar et al.   BMC BIOINFORMATICS

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

(2009) Koji Okamoto et al.   FEBS LETTERS

Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells

(2009) B. Huang et al.   MOLECULAR CANCER RESEARCH

Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?

(2009) Mark Wade et al.   MOLECULAR CANCER RESEARCH

Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition

(2009) Andrea Carotti et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition

(2008) Antonio Macchiarulo et al.   Journal of Chemical Information and Modeling

Quantitative Lid Dynamics of MDM2 Reveals Differential Ligand Binding Modes of the p53-Binding Cleft

(2008) Scott A. Showalter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY