Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

The Mdm2 and p53 genes are conserved in the Arachnids

(2011) David P. Lane et al.   CELL CYCLE

p53 and its mutants in tumor cell migration and invasion

(2011) Patricia A. J. Muller et al.   JOURNAL OF CELL BIOLOGY

Mdm2 and p53 are highly conserved from placozoans to man

(2010) David P. Lane et al.   CELL CYCLE

Turning the RING Domain Protein MdmX into an Active Ubiquitin-Protein Ligase

(2010) Saravanakumar Iyappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2

(2010) Jonathan Shloush et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

(2009) Koji Okamoto et al.   FEBS LETTERS

Deregulating EMT and Senescence: Double Impact by a Single Twist

(2008) Marjon A. Smit et al.   CANCER CELL

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

(2008) K Linke et al.   CELL DEATH AND DIFFERENTIATION

Twist and p53 reciprocally regulate target genes via direct interaction

(2008) M Shiota et al.   ONCOGENE