Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives

Stem cell-based delivery of brain-derived neurotrophic factor gene in the rat retina

(2012) Hae-Young Lopilly Park et al.   BRAIN RESEARCH

Stimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling

(2012) Dietmar Fischer   CELL AND TISSUE RESEARCH

Traumatology of the optic nerve and contribution of crystallins to axonal regeneration

(2012) Solon Thanos et al.   CELL AND TISSUE RESEARCH

Neurotrophic factors in combinatorial approaches for spinal cord regeneration

(2012) Julianne McCall et al.   CELL AND TISSUE RESEARCH

Insulin-Like Growth Factor-1 and Central Neurodegenerative Diseases

(2012) Ignacio Torres Aleman   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease

(2012) M. Decressac et al.   EXPERIMENTAL NEUROLOGY

The Neuroprotective Functions of Transforming Growth Factor Beta Proteins

(2012) Arpád Dobolyi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Local axonal function of STAT3 rescues axon degeneration in thepmnmodel of motoneuron disease

(2012) Bhuvaneish Thangaraj Selvaraj et al.   JOURNAL OF CELL BIOLOGY

‘‘70th Birthday Professor Riederer’’ Induction of glial cell line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy?

(2012) Wakako Maruyama et al.   JOURNAL OF NEURAL TRANSMISSION

Intrinsically determined cell death of developing cortical interneurons

(2012) Derek G. Southwell et al.   NATURE

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Advancing neurotrophic factors as treatments for age-related neurodegenerative diseases: developing and demonstrating “clinical proof-of-concept” for AAV-neurturin (CERE-120) in Parkinson's disease

(2012) Raymond T. Bartus et al.   NEUROBIOLOGY OF AGING

Prolonged survival and milder impairment of motor function in the SOD1 ALS mouse model devoid of fibroblast growth factor 2

(2012) Nadine Thau et al.   NEUROBIOLOGY OF DISEASE

Translating the therapeutic potential of neurotrophic factors to clinical ‘proof of concept’: A personal saga achieving a career-long quest

(2012) Raymond T. Bartus   NEUROBIOLOGY OF DISEASE

Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells

(2012) Glyn Chidlow et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective and memory enhancing properties of a dual agonist of the FGF receptor and NCAM

(2012) Maj N. Enevoldsen et al.   NEUROBIOLOGY OF DISEASE

The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior

(2012) Cortney A. Turner et al.   NEURON

Long-Term Gene Therapy Causes Transgene-Specific Changes in the Morphology of Regenerating Retinal Ganglion Cells

(2012) Jennifer Rodger et al.   PLoS One

N-acetyl serotonin derivatives as potent neuroprotectants for retinas

(2012) J. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Rodent Model of Posterior Ischemic Optic Neuropathy

(2012) Yan Wang et al.   JAMA Ophthalmology

Toward Neurotrophin-Based Therapeutics

(2011) Lisa M. Monteggia   AMERICAN JOURNAL OF PSYCHIATRY

GDNF fails to exert neuroprotection in a rat  -synuclein model of Parkinson's disease

(2011) M. Decressac et al.   BRAIN

Klf10 and Klf11 as mediators of TGF-beta superfamily signaling

(2011) Björn Spittau et al.   CELL AND TISSUE RESEARCH

The role of TGF-β in the pathogenesis of primary open-angle glaucoma

(2011) Rudolf Fuchshofer et al.   CELL AND TISSUE RESEARCH

Vascular damage in the central nervous system: a multifaceted role for vascular-derived TGF-β

(2011) Kristina Beck et al.   CELL AND TISSUE RESEARCH

TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β

(2011) Hiroaki Ikushima et al.   CELL AND TISSUE RESEARCH

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

(2011) Michael K. Wendt et al.   CELL AND TISSUE RESEARCH

Role of Smads in TGFβ signaling

(2011) Carl-Henrik Heldin et al.   CELL AND TISSUE RESEARCH

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Apoptosis

(2011) Tommy Seaborn et al.   CURRENT PHARMACEUTICAL DESIGN

IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy

(2011) Panagiota Miltiadous et al.   EXPERIMENTAL NEUROLOGY

Fibroblast growth factor-2 deficiency causes defects in adult hippocampal neurogenesis, which are not rescued by exogenous fibroblast growth factor-2

(2011) Sandra Werner et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease

(2011) Raymond T. Bartus et al.   NEUROBIOLOGY OF DISEASE

IGF-1 delivery to CNS attenuates motor neuron cell death but does not improve motor function in type III SMA mice

(2011) Li-Kai Tsai et al.   NEUROBIOLOGY OF DISEASE

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

(2011) M. Decressac et al.   NEUROBIOLOGY OF DISEASE

CNTF and retina

(2011) Rong Wen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses

(2011) Kerstin Krieglstein et al.   TRENDS IN NEUROSCIENCES

Branched oligomerization of cell-permeable peptides markedly enhances the transduction efficiency of adenovirus into mesenchymal stem cells

(2010) S-H Park et al.   GENE THERAPY

Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTRActivity Is Neurotoxic through a Paracrine Mechanism

(2010) Yujing Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation

(2010) Zhongshu Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ciliary Neurotrophic Factor Cell-Based Delivery Prevents Synaptic Impairment and Improves Memory in Mouse Models of Alzheimer's Disease

(2010) P. Garcia et al.   JOURNAL OF NEUROSCIENCE

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease

(2010) Yulia A. Sidorova et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repairing the parkinsonian brain with neurotrophic factors

(2010) Liviu Aron et al.   TRENDS IN NEUROSCIENCES

Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration

(2009) Tamas Atlasz et al.   BRAIN RESEARCH BULLETIN

Regulation of Brain-Derived Neurotrophic Factor (BDNF) and Cerebral Dopamine Neurotrophic Factor (CDNF) by Anti-Parkinsonian Drug Therapy In Vivo

(2009) Tobias Gyárfás et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

Neuroprotective and Axon Growth-Promoting Effects following Inflammatory Stimulation on Mature Retinal Ganglion Cells in Mice Depend on Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor

(2009) M. Leibinger et al.   JOURNAL OF NEUROSCIENCE

Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF

(2009) Adrienne Müller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma

(2009) Q.-L. Fu et al.   NEUROSCIENCE

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acknowledgements

(2008)   ACTA OPHTHALMOLOGICA

Retinal p75 and bax overexpression is associated with retinal ganglion cells apoptosis in a rat model of glaucoma

(2008) Marco Coassin et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

(2008) Päivi Lindholm et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibition of p75NTR in glia potentiates TrkA-mediated survival of injured retinal ganglion cells

(2008) Frédéric Lebrun-Julien et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma

(2008) Valentina Sposato et al.   NEUROSCIENCE LETTERS

Brain-Derived Neurotrophic Factor But Not Forced Arm Use Improves Long-Term Outcome After Photothrombotic Stroke and Transiently Upregulates Binding Densities of Excitatory Glutamate Receptors in the Rat Brain

(2008) Harald D. Müller et al.   STROKE

The Transforming Growth Factor-βs

(2003) Martina Böttner et al.   JOURNAL OF NEUROCHEMISTRY