Genetic models of schizophrenia and related psychotic disorders: progress and pitfalls across the methodological “minefield”

Deconstructing negative symptoms of schizophrenia: Avolition–apathy and diminished expression clusters predict clinical presentation and functional outcome

(2013) Gregory P. Strauss et al.   JOURNAL OF PSYCHIATRIC RESEARCH

D-Amphetamine and Antipsychotic Drug Effects on Latent Inhibition in Mice Lacking Dopamine D2 Receptors

(2013) C Bay-Richter et al.   NEUROPSYCHOPHARMACOLOGY

Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence

(2012) Mario Fioravanti et al.   BMC Psychiatry

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene×environment interaction

(2012) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

The Shock of the New: Progress in Schizophrenia Genomics

(2012) Susan Moore et al.   CURRENT GENOMICS

Mice with reduced NMDA receptor expression: more consistent with autism than schizophrenia?

(2012) M. J. Gandal et al.   GENES BRAIN AND BEHAVIOR

Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap

(2012) Judith Pratt et al.   NATURE REVIEWS DRUG DISCOVERY

Optogenetic investigation of neural circuits underlying brain disease in animal models

(2012) Kay M. Tye et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Adolescent Exposure to Delta-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Indices of Dopaminergic, Endocannabinoid and GABAergic Pathways

(2012) Áine T Behan et al.   NEUROPSYCHOPHARMACOLOGY

Differentiation of Schizophrenia Patients from Healthy Subjects by Mismatch Negativity and Neuropsychological Tests

(2012) Yi-Ting Lin et al.   PLoS One

Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice

(2012) Leonora E. Long et al.   PLoS One

Factor structure of the brief negative symptom scale

(2012) Gregory P. Strauss et al.   SCHIZOPHRENIA RESEARCH

Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome

(2012) S Kimoto et al.   Translational Psychiatry

Modeling schizophrenia: uncovering novel therapeutic targets

(2012) Lieve Desbonnet et al.   Expert Review of Clinical Pharmacology

Do transmembrane domain neuregulin 1 mutant mice exhibit a reliable sensorimotor gating deficit?

(2011) T. Karl et al.   BEHAVIOURAL BRAIN RESEARCH

Modeling motivational deficits in mouse models of schizophrenia: Behavior analysis as a guide for neuroscience

(2011) Ryan D. Ward et al.   BEHAVIOURAL PROCESSES

Animal Model for Schizophrenia That Reflects Gene-Environment Interactions

(2011) Taku Nagai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Animal models of schizophrenia

(2011) CA Jones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transgenic Overexpression of the Type I Isoform of Neuregulin 1 Affects Working Memory and Hippocampal Oscillations but not Long-term Potentiation

(2011) Inga H. Deakin et al.   CEREBRAL CORTEX

Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: Implications for neurodevelopmental disorders

(2011) Laura R. Schaevitz et al.   Developmental Neurobiology

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

(2011) Colm M. P. O'Tuathaigh et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mouse pharmacological models of cognitive disruption relevant to schizophrenia

(2011) Jared W. Young et al.   NEUROPHARMACOLOGY

Timing as a window on cognition in schizophrenia

(2011) Ryan D. Ward et al.   NEUROPHARMACOLOGY

Mouse models of genetic effects on cognition: Relevance to schizophrenia

(2011) Francesco Papaleo et al.   NEUROPHARMACOLOGY

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

(2011) L. Lyon et al.   PSYCHOPHARMACOLOGY

Schizophrenia, “Just the Facts” 6. Moving ahead with the schizophrenia concept: From the elephant to the mouse

(2011) Matcheri S. Keshavan et al.   SCHIZOPHRENIA RESEARCH

Cognition and disability in bipolar disorder: lessons from schizophrenia research

(2010) Philip D Harvey et al.   BIPOLAR DISORDERS

Mouse behavioral endophenotypes for schizophrenia

(2010) Laura C. Amann et al.   BRAIN RESEARCH BULLETIN

Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice

(2010) Philipp Singer et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The puzzle box as a simple and efficient behavioral test for exploring impairments of general cognition and executive functions in mouse models of schizophrenia

(2010) Nada M.-B. Ben Abdallah et al.   EXPERIMENTAL NEUROLOGY

A Longitudinal Examination of the Neurodevelopmental Impact of Prenatal Immune Activation in Mice Reveals Primary Defects in Dopaminergic Development Relevant to Schizophrenia

(2010) S. Vuillermot et al.   JOURNAL OF NEUROSCIENCE

Mouse phenotyping

(2010) Helmut Fuchs et al.   METHODS

Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia

(2010) T Kato et al.   MOLECULAR PSYCHIATRY

Rethinking schizophrenia

(2010) Thomas R. Insel   NATURE

The environment and schizophrenia

(2010) Jim van Os et al.   NATURE

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

(2010) Maria Karayiorgou et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

(2010) Colm MP O'Tuathaigh et al.   NEUROPSYCHOPHARMACOLOGY

Cognition in transmembrane domain neuregulin 1 mutant mice

(2010) L. Duffy et al.   NEUROSCIENCE

Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

(2010) Joanna C. Neill et al.   PHARMACOLOGY & THERAPEUTICS

Phenotypic Characterization of Transgenic Mice Overexpressing Neuregulin-1

(2010) Taisuke Kato et al.   PLoS One

Gene–environment interactions and construct validity in preclinical models of psychiatric disorders

(2010) Emma L. Burrows et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A follow-up study: acute behavioural effects of Δ9-THC in female heterozygous Neuregulin 1 transmembrane domain mutant mice

(2010) Leonora E. Long et al.   PSYCHOPHARMACOLOGY

The Brief Negative Symptom Scale: Psychometric Properties

(2010) Brian Kirkpatrick et al.   SCHIZOPHRENIA BULLETIN

Schizophrenia, “Just the Facts” 5. Treatment and prevention Past, present, and future

(2010) Rajiv Tandon et al.   SCHIZOPHRENIA RESEARCH

Impaired timing precision produced by striatal D2 receptor overexpression is mediated by cognitive and motivational deficits.

(2009) Ryan D. Ward et al.   BEHAVIORAL NEUROSCIENCE

Mice mutant for genes associated with schizophrenia: Common phenotype or distinct endophenotypes?

(2009) Lieve Desbonnet et al.   BEHAVIOURAL BRAIN RESEARCH

Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions

(2009) Richard S. Ehrlichman et al.   BRAIN RESEARCH

Advancing a functional genomics for schizophrenia: Psychopathological and cognitive phenotypes in mutants with gene disruption

(2009) Brian P. Kirby et al.   BRAIN RESEARCH BULLETIN

Schizophrenia genetics: advancing on two fronts

(2009) Michael J Owen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia

(2009) T. B. Halene et al.   GENES BRAIN AND BEHAVIOR

Genetics of psychosis; insights from views across the genome

(2009) Michael C. O’Donovan et al.   HUMAN GENETICS

Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation

(2009) Maarten van den Buuse et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Deficient NRG1-ERBB signaling alters social approach: relevance to genetic mouse models of schizophrenia

(2009) Sheryl S. Moy et al.   Journal of Neurodevelopmental Disorders

Schizophrenia

(2009) Jim van Os et al.   LANCET

Behavioural characterization of neuregulin 1 type I overexpressing transgenic mice

(2009) Inga H. Deakin et al.   NEUROREPORT

Mice with genetically altered glutamate receptors as models of schizophrenia: A comprehensive review

(2009) Dragos Inta et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood

(2009) Daisuke Ibi et al.   NEUROSCIENCE RESEARCH

Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons

(2009) L. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome

(2009) D. W. Meechan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system

(2009) C. S. Barros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognition in Mouse Models of Schizophrenia Susceptibility Genes

(2009) P. A. Arguello et al.   SCHIZOPHRENIA BULLETIN

Mutant Mouse Models: Genotype-Phenotype Relationships to Negative Symptoms in Schizophrenia

(2009) C. M. P. O'Tuathaigh et al.   SCHIZOPHRENIA BULLETIN

Modeling the Positive Symptoms of Schizophrenia in Genetically Modified Mice: Pharmacology and Methodology Aspects

(2009) M. van den Buuse   SCHIZOPHRENIA BULLETIN

Schizophrenia, “just the facts” 4. Clinical features and conceptualization

(2009) Rajiv Tandon et al.   SCHIZOPHRENIA RESEARCH

Modeling cognitive endophenotypes of schizophrenia in mice

(2009) Christoph Kellendonk et al.   TRENDS IN NEUROSCIENCES

Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1.

(2008) Liesl Duffy et al.   BEHAVIORAL NEUROSCIENCE

Candidate genes and the behavioral phenotype in 22q11.2 deletion syndrome

(2008) Sarah E. Prasad et al.   Developmental Disabilities Research Reviews

Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action

(2008) Cecilie Bay-Richter et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Type III Neuregulin-1 Is Required for Normal Sensorimotor Gating, Memory-Related Behaviors, and Corticostriatal Circuit Components

(2008) Y.-J. J. Chen et al.   JOURNAL OF NEUROSCIENCE

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

(2008) Nicole C Allen et al.   NATURE GENETICS

Psychiatric genetics: progress amid controversy

(2008) Margit Burmeister et al.   NATURE REVIEWS GENETICS

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Negative Symptoms in Schizophrenia: Avolition and Occam's Razor

(2008) G. Foussias et al.   SCHIZOPHRENIA BULLETIN

Schizophrenia, “just the facts”: What we know in 2008Part 3: Neurobiology

(2008) M KESHAVAN et al.   SCHIZOPHRENIA RESEARCH

Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology

(2008) R TANDON et al.   SCHIZOPHRENIA RESEARCH

Suitability of tamoxifen-induced mutagenesis for behavioral phenotyping

(2007) M.A. Vogt et al.   EXPERIMENTAL NEUROLOGY

Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous ‘knockout’ of the schizophrenia risk gene neuregulin-1

(2007) Colm M.P. O'Tuathaigh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY