Modeling schizophrenia: uncovering novel therapeutic targets

Social defeat interacts with Disc1 mutations in the mouse to affect behavior

(2012) F. Nipa Haque et al.   BEHAVIOURAL BRAIN RESEARCH

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: A putative model of gene×environment interaction

(2012) Lieve Desbonnet et al.   BRAIN BEHAVIOR AND IMMUNITY

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

(2012) Dheeraj Malhotra et al.   CELL

Minocycline

(2012) Olivia M. Dean et al.   CNS DRUGS

Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism

(2012) Alan S. Brown   Developmental Neurobiology

Sensory and Sensorimotor Gating Deficits after Neonatal Ventral Hippocampal Lesions in Rats

(2012) Neal R. Swerdlow et al.   DEVELOPMENTAL NEUROSCIENCE

Clozapine for the treatment of schizophrenia

(2012) Eric Fakra et al.   EXPERT OPINION ON PHARMACOTHERAPY

Prenatal Immune Activation Interacts with Genetic Nurr1 Deficiency in the Development of Attentional Impairments

(2012) S. Vuillermot et al.   JOURNAL OF NEUROSCIENCE

Intact neurobehavioral development and dramatic impairments of procedural-like memory following neonatal ventral hippocampal lesion in rats

(2012) L. Lecourtier et al.   NEUROSCIENCE

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

(2012) B. H. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-Cycloserine: An Evolving Role in Learning and Neuroplasticity in Schizophrenia

(2012) D. C. Goff   SCHIZOPHRENIA BULLETIN

Prenatal immune challenge in rats: Altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC

(2012) Charles V. Vorhees et al.   SYNAPSE

Cognitive, Behavioural and Psychiatric Phenotype in 22q11.2 Deletion Syndrome

(2011) Nicole Philip et al.   BEHAVIOR GENETICS

Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

(2011) Amy R. Wolff et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of risperidone treatment in adolescence on hippocampal neurogenesis, parvalbumin expression, and vascularization following prenatal immune activation in rats

(2011) Yael Piontkewitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Biological pathways to adaptability - interactions between genome, epigenome, nervous system and environment for adaptive behavior

(2011) C. Wolf et al.   GENES BRAIN AND BEHAVIOR

Prenatal immune challenge compromises the normal course of neurogenesis during development of the mouse cerebral cortex

(2011) Hitomi Soumiya et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Peripheral immune challenge with viral mimic during early postnatal period robustly enhances anxiety-like behavior in young adult rats

(2011) Gregory W. Konat et al.   METABOLIC BRAIN DISEASE

Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression

(2011) R M O'Connor et al.   MOLECULAR PSYCHIATRY

Inside the minds of mice and men

(2011) Monya Baker   NATURE

City living and urban upbringing affect neural social stress processing in humans

(2011) Florian Lederbogen et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

MicroRNA dysregulation in schizophrenia

(2011) Natalie J. Beveridge et al.   NEUROBIOLOGY OF DISEASE

Clozapine administration reverses behavioral, neuronal, and nitric oxide disturbances in the neonatal ventral hippocampus rat

(2011) Maria Elena Bringas et al.   NEUROPHARMACOLOGY

To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models

(2011) Urs Meyer et al.   NEUROPHARMACOLOGY

Cortical disinhibition in the neonatal ventral hippocampal lesion model of schizophrenia: New vistas on possible therapeutic approaches

(2011) Patricio O'Donnell   PHARMACOLOGY & THERAPEUTICS

Glutamate signaling in the pathophysiology and therapy of schizophrenia

(2011) Chieh-Hsin Lin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Challenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia

(2011) Peter L. Oliver   TheScientificWorldJOURNAL

Beyond the facts in schizophrenia: closing the gaps in diagnosis, pathophysiology, and treatment

(2011) H. Nasrallah et al.   Epidemiology and Psychiatric Sciences

Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling

(2010) Bruce S. McEwen   Annals of the New York Academy of Sciences

Stress- and Allostasis-Induced Brain Plasticity

(2010) Bruce S. McEwen et al.   Annual Review of Medicine

Effect of ‘chronic’ versus ‘acute’ ketamine administration and its ‘withdrawal’ effect on behavioural alterations in mice: Implications for experimental psychosis

(2010) Manavi Chatterjee et al.   BEHAVIOURAL BRAIN RESEARCH

Prenatal Interaction of Mutant DISC1 and Immune Activation Produces Adult Psychopathology

(2010) Bagrat Abazyan et al.   BIOLOGICAL PSYCHIATRY

Strategies to Enhance N-Methyl-D-Aspartate Receptor-Mediated Neurotransmission in Schizophrenia, a Critical Review and Meta-Analysis

(2010) Guochuan Tsai et al.   CURRENT PHARMACEUTICAL DESIGN

Development of animal models for schizophrenia

(2010) P. A. Arguello et al.   Disease Models & Mechanisms

More Is Less: A Disinhibited Prefrontal Cortex Impairs Cognitive Flexibility

(2010) A. J. Gruber et al.   JOURNAL OF NEUROSCIENCE

Mesolimbic Dopamine Neurons in the Brain Reward Circuit Mediate Susceptibility to Social Defeat and Antidepressant Action

(2010) J.-L. Cao et al.   JOURNAL OF NEUROSCIENCE

Novel animal models for studying complex brain disorders: BAC-driven miRNA-mediated in vivo silencing of gene expression

(2010) K A Garbett et al.   MOLECULAR PSYCHIATRY

The environment and schizophrenia

(2010) Jim van Os et al.   NATURE

22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia

(2010) Maria Karayiorgou et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

(2010) Colm MP O'Tuathaigh et al.   NEUROPSYCHOPHARMACOLOGY

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

Pharmacological characterization of social isolation-induced hyperactivity

(2010) Katrine Fabricius et al.   PSYCHOPHARMACOLOGY

Mice mutant for genes associated with schizophrenia: Common phenotype or distinct endophenotypes?

(2009) Lieve Desbonnet et al.   BEHAVIOURAL BRAIN RESEARCH

Gestational methylazoxymethanol acetate administration: A developmental disruption model of schizophrenia

(2009) Daniel J. Lodge et al.   BEHAVIOURAL BRAIN RESEARCH

MicroRNAs in Mental Health: From Biological Underpinnings to Potential Therapies

(2009) Joshua G. Hunsberger et al.   NEUROMOLECULAR MEDICINE

Modelling prefrontal cortex deficits in schizophrenia: implications for treatment

(2008) J A Pratt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neonatal ventral hippocampus lesions disrupt extra-dimensional shift and alter dendritic spine density in the medial prefrontal cortex of juvenile rats

(2008) Jean-Philippe Marquis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy

(2008) U. Meyer et al.   NEUROSCIENCE

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

(2008) Kevin C.F. Fone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection

(2008) J. A. Lieberman et al.   PHARMACOLOGICAL REVIEWS

Molecular architecture of a miRNA-regulated 3' UTR

(2008) D. Didiano et al.   RNA