Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

Mechanistic studies of antibody mediated clearance of tau aggregates using an ex vivo brain slice model

(2010) Pavan K. Krishnamurthy et al.   Alzheimers & Dementia

Passive tau immunotherapy diminishes functional decline and clears tau aggregates in a mouse model of tauopathy

(2010) Allal Boutajangout et al.   Alzheimers & Dementia

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

(2010) Moran Boimel et al.   EXPERIMENTAL NEUROLOGY

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

(2010) A. Boutajangout et al.   JOURNAL OF NEUROSCIENCE

Systemic inflammatory cells fight off neurodegenerative disease

(2010) Michal Schwartz et al.   Nature Reviews Neurology

T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease

(2010) Yair Fisher et al.   PLoS One

Tau-Focused Immunotherapy for Alzheimers Disease and Related Tauopathies

(2009) Einar Sigurdsson   Current Alzheimer Research

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET