Inactivation of PI3-K/Akt and reduction of SP1 and p65 expression increase the effect of solamargine on suppressing EP4 expression in human lung cancer cells

Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway

(2015) Yan Guo et al.   APOPTOSIS

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model

(2015) Sheetal Parida et al.   CANCER BIOLOGY & THERAPY

NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells

(2015) Daniela Schilling et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

β-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPKα signalling pathways in human lung cancer cells: the role of Sp1

(2015) ShunYu Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells

(2015) Jingjing Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

MicroRNA-144 inhibits the metastasis of gastric cancer by targeting MET expression

(2015) Jun Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy

(2015) G. Xue et al.   JNCI-Journal of the National Cancer Institute

LPS Increases 5-LO Expression on Monocytes via an Activation of Akt-Sp1/NF-κB Pathways

(2015) Seung Jin Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer

(2015) Shiro Koizume et al.   Molecular Cancer

COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation

(2015) M. Majumder et al.   MOLECULAR CANCER RESEARCH

Liquiritigenin Potentiates the Inhibitory Effects of Cisplatin on Invasion and Metastasis Via Downregulation MMP-2/9 and PI3 K/AKT Signaling Pathway in B16F10 Melanoma Cells and Mice Model

(2015) Hui Shi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity

(2015) Iman Karimi Sani et al.   TOXICOLOGY IN VITRO

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation

(2015) Tetsuyuki Takahashi et al.   Oncotarget

FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

(2015) Guanzhen Yu et al.   Oncotarget

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

(2015) Huiyoung Yun et al.   Oncotarget

Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways

(2015) Ruolin Zhao et al.   Journal of Cancer

Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy

(2015) G. Xue et al.   JNCI-Journal of the National Cancer Institute

NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling

(2015) Cuixiang Zhang et al.   Oncotarget

Synergistic anti-tumor effects of a novel phosphatidyl inositol-3 kinase/mammalian target of rapamycin dual inhibitor BGT226 and gefitinib in non-small cell lung cancer cell lines

(2014) Yasufumi Katanasaka et al.   CANCER LETTERS

Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions

(2014) Mousumi Majumder et al.   CANCER SCIENCE

Improving chemoradiation efficacy by PI3-K/AKT inhibition

(2014) Hanneke Stegeman et al.   CANCER TREATMENT REVIEWS

Chemo-sensitizing effects of EP4 receptor-induced inactivation of nuclear factor-κB

(2014) Martina Gobec et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models

(2014) Yiqing Qu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting signal transducer and activator of transcription 3 contributes to the solamargine-inhibited growth and -induced apoptosis of human lung cancer cells

(2014) Yan Zhou et al.   TUMOR BIOLOGY

Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H 2 O 2 production and Sp1/c-Jun cooperation

(2013) Akira Ikari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling: The role of PGC-1α and Sp1

(2013) Swei Sunny Hann et al.   CELLULAR SIGNALLING

TGF-β Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2through Activation of PI3K/AKT/mTOR Pathway

(2013) BaoHan T. Vo et al.   ENDOCRINOLOGY

Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines

(2013) Carla Carolina Munari et al.   Journal of Natural Medicines

NF-κB-dependent IL-8 induction by prostaglandin E2receptors EP1and EP4

(2012) F Neuschäfer-Rube et al.   BRITISH JOURNAL OF PHARMACOLOGY

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer

(2012) Huizhong Hu et al.   CELLULAR SIGNALLING

The Maternally Expressed GeneTssc3Regulates the Expression of MASH2 Transcription Factor in Mouse Trophoblast Stem Cells through the AKT-Sp1 Signaling Pathway

(2012) Tomoka Takao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells

(2012) Ingun Tveteraas et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

EP4 receptor signalling in immature B cells involves cAMP and NF-κB dependent pathways

(2012) Matevz Prijatelj et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen

(2011) Y. Yamauchi et al.   CANCER RESEARCH

The p65 Subunit of NF-κB InhibitsCOL1A1Gene Transcription in Human Dermal and Scleroderma Fibroblasts through Its Recruitment on Promoter by Protein Interaction with Transcriptional Activators (c-Krox, Sp1, and Sp3)

(2011) Gallic Beauchef et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L.

(2011) Xia Ding et al.   JOURNAL OF ETHNOPHARMACOLOGY

Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells

(2010) Lingmei Sun et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Cyclooxygenase Inhibitor Sulindac Sulfide Inhibits EP4 Expression and Suppresses the Growth of Glioblastoma Cells

(2009) A. Kambe et al.   Cancer Prevention Research

The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer

(2009) Olga C.J. Schuurbiers et al.   Journal of Thoracic Oncology

Regulation of EP4 expression via the Sp-1 transcription factor: Inhibition of expression by anti-cancer agents

(2008) Atsushi Kambe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Neuronal Injury-inducible Gene Is Synergistically Regulated by ATF3, c-Jun, and STAT3 through the Interaction with Sp1 in Damaged Neurons

(2008) Sumiko Kiryu-Seo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY