Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions

Tumor-Initiating and -Propagating Cells: Cells That We Would to Identify and Control

(2015) Berit Bølge Tysnes   NEOPLASIA

Cancer Stem-like Cells Derived from Chemoresistant Tumors Have a Unique Capacity to Prime Tumorigenic Myeloid Cells

(2014) T. Yamashina et al.   CANCER RESEARCH

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

(2013) Y. M. Ikushima et al.   BLOOD

Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties

(2013) Namita Kundu et al.   BREAST CANCER RESEARCH AND TREATMENT

A practical and sensitive method of quantitating lymphangiogenesis in vivo

(2013) Mousumi Majumder et al.   LABORATORY INVESTIGATION

Embryonic Stem Cells Markers SOX2, OCT4 and Nanog Expression and Their Correlations with Epithelial-Mesenchymal Transition in Nasopharyngeal Carcinoma

(2013) Weiren Luo et al.   PLoS One

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis

(2013) Xinrong Ma et al.   OncoImmunology

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

(2012) Catharina Medrek et al.   BMC CANCER

Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model

(2012) Xiping Xin et al.   LABORATORY INVESTIGATION

Co-Expression of α9β1 Integrin and VEGF-D Confers Lymphatic Metastatic Ability to a Human Breast Cancer Cell Line MDA-MB-468LN

(2012) Mousumi Majumder et al.   PLoS One

The COX-2/PGI2 Receptor Axis Plays an Obligatory Role in Mediating the Cardioprotection Conferred by the Late Phase of Ischemic Preconditioning

(2012) Yiru Guo et al.   PLoS One

Sphere Culture of Murine Lung Cancer Cell Lines Are Enriched with Cancer Initiating Cells

(2012) Brian J. Morrison et al.   PLoS One

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2

(2011) Xinrong Ma et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer

(2010) Rabindra N. Bhattacharjee et al.   CANCER SCIENCE

Tumor-secreted PGE2Inhibits CCL5 Production in Activated Macrophages through cAMP/PKA Signaling Pathway

(2010) Xuesong Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line

(2010) Balraj Singh et al.   JOURNAL OF SURGICAL RESEARCH

Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4- Arrestin1-c-Src Signalsome

(2010) J. I. Kim et al.   MOLECULAR CANCER RESEARCH

Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation

(2007) Akio Murase et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP4 receptor antagonist

(2007) Akio Murase et al.   LIFE SCIENCES