Systems biology approaches to heart development and congenital heart disease

Epigenetic regulation of cardiovascular differentiation

(2011) K. Ohtani et al.   CARDIOVASCULAR RESEARCH

Systems Biology: Evolving into the Mainstream

(2011) Colin Macilwain   CELL

Chromatin Remodeling in Cardiovascular Development and Physiology

(2011) Pei Han et al.   CIRCULATION RESEARCH

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

A Comparison of Single Molecule and Amplification Based Sequencing of Cancer Transcriptomes

(2011) Lee T. Sam et al.   PLoS One

The Cardiac Transcription Network Modulated by Gata4, Mef2a, Nkx2.5, Srf, Histone Modifications, and MicroRNAs

(2011) Jenny Schlesinger et al.   PLoS Genetics

Computational analysis of microRNA function in heart development

(2010) Ganqiang Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Genomic Screening with RNAi: Results and Challenges

(2010) Stephanie Mohr et al.   Annual Review of Biochemistry

A Decade of Systems Biology

(2010) Han-Yu Chuang et al.   Annual Review of Cell and Developmental Biology

Stem Cell Models of Cardiac Development and Disease

(2010) Kiran Musunuru et al.   Annual Review of Cell and Developmental Biology

Reverse genetics in eukaryotes

(2010) Serge Hardy et al.   BIOLOGY OF THE CELL

Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy

(2010) Chen-Ching Lin et al.   BMC Systems Biology

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Heterogeneity of Genetic Modifiers Ensures Normal Cardiac Development

(2010) Julia B. Winston et al.   CIRCULATION

Systems Biology: An Approach

(2010) P Kohl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Data integration and analysis of biological networks

(2010) Tae Yong Kim et al.   CURRENT OPINION IN BIOTECHNOLOGY

Collective cell migration of the cephalic neural crest: The art of integrating information

(2010) Eric Theveneau et al.   GENESIS

Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left–right patterning defects

(2010) Jamie Bentham et al.   HUMAN MOLECULAR GENETICS

A window into third-generation sequencing

(2010) E. E. Schadt et al.   HUMAN MOLECULAR GENETICS

Mn8and Mn16Clusters from the Use of 2-(Hydroxymethyl)pyridine, and Comparison with the Products from Bulkier Chelates: A New High Nuclearity Single-Molecule Magnet

(2010) Taketo Taguchi et al.   INORGANIC CHEMISTRY

The SILAC Fly Allows for Accurate Protein Quantificationin Vivo

(2010) Matthias D. Sury et al.   MOLECULAR & CELLULAR PROTEOMICS

Dissecting spatio-temporal protein networks driving human heart development and related disorders

(2010) Kasper Lage et al.   Molecular Systems Biology

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

(2010) Xonia Carvajal-Vergara et al.   NATURE

Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

(2010) Chang Tong et al.   NATURE

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells

(2010) Zsuzsanna Izsvák et al.   NATURE METHODS

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Visualization of omics data for systems biology

(2010) Nils Gehlenborg et al.   NATURE METHODS

Towards genome-scale signalling-network reconstructions

(2010) Daniel R. Hyduke et al.   NATURE REVIEWS GENETICS

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Mouse Genome Database (MGD): premier model organism resource for mammalian genomics and genetics

(2010) J. A. Blake et al.   NUCLEIC ACIDS RESEARCH

The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium

(2010) M. Ringwald et al.   NUCLEIC ACIDS RESEARCH

From ‘differential expression’ to ‘differential networking’ – identification of dysfunctional regulatory networks in diseases

(2010) Alberto de la Fuente   TRENDS IN GENETICS

Joint dynamic imaging of morphogenesis and function in the developing heart

(2010) Jungho Ohn et al.   Organogenesis

A Model for Genetic and Epigenetic Regulatory Networks Identifies Rare Pathways for Transcription Factor Induced Pluripotency

(2010) Maxim N. Artyomov et al.   PLoS Computational Biology

Folic Acid Supplementation Cardiovascular Disease: The State of the Art

(2009) Lydia A. Bazzano   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells

(2009) Jizhong Zou et al.   Cell Stem Cell

Human stem cells as a model for cardiac differentiation and disease

(2009) A. Beqqali et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion

(2009) Aslan T. Turer et al.   CIRCULATION

Recurrence of Congenital Heart Defects in Families

(2009) Nina Øyen et al.   CIRCULATION

Next-Generation Sequencing: From Basic Research to Diagnostics

(2009) K. V. Voelkerding et al.   CLINICAL CHEMISTRY

3D MRI heart segmentation of mouse embryos

(2009) T. Zouagui et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

(2009) Masaki Ieda et al.   DEVELOPMENTAL CELL

Database of queryable gene expression patterns forXenopus

(2009) Michael J. Gilchrist et al.   DEVELOPMENTAL DYNAMICS

Legal and ethical consequences of international biobanking from a national perspective: the German BMB-EUCoop project

(2009) Jürgen W Goebel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Systems biology and heart failure: concepts, methods, and potential research applications

(2009) Kirkwood F. Adams   HEART FAILURE REVIEWS

ATP-Sensitive K+Channel Knockout Induces Cardiac Proteome Remodeling Predictive of Heart Disease Susceptibility

(2009) D. Kent Arrell et al.   JOURNAL OF PROTEOME RESEARCH

Systems biology and the virtual physiological human

(2009) Peter Kohl et al.   Molecular Systems Biology

Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture

(2009) Raja Jothi et al.   Molecular Systems Biology

Combinatorial binding predicts spatio-temporal cis-regulatory activity

(2009) Robert P. Zinzen et al.   NATURE

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Genetic and Genomic Dissection of Cardiogenesis in the Drosophila Model

(2009) Ingolf Reim et al.   PEDIATRIC CARDIOLOGY

Multiscale, multiorgan and multivariate complexity analyses of cardiovascular regulation

(2009) S. Cerutti et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects

(2009) Anjali K. Nath et al.   PLoS One

Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells

(2009) I. J. Domian et al.   SCIENCE

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Global Expression Profile of Highly Enriched Cardiomyocytes Derived from Human Embryonic Stem Cells

(2009) Xiu Qin Xu et al.   STEM CELLS

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function

(2008) Marcus Krüger et al.   CELL

High-speed imaging of developing heart valves reveals interplay of morphogenesis and function

(2008) P. J. Scherz et al.   DEVELOPMENT

Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells

(2008) Nicolas Pilon et al.   DEVELOPMENTAL DYNAMICS

The Cardiac Physiome: perspectives for the future

(2008) James Bassingthwaighte et al.   EXPERIMENTAL PHYSIOLOGY

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex

(2008) M. Lange et al.   GENES & DEVELOPMENT

Method for inferring and extracting reliable genetic interactions from time-series profile of gene expression

(2008) Masahiko Nakatsui et al.   MATHEMATICAL BIOSCIENCES

Prediction of cardiac transcription networks based on molecular data and complex clinical phenotypes

(2008) Martje Toenjes et al.   Molecular BioSystems

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

The developmental genetics of congenital heart disease

(2008) Benoit G. Bruneau   NATURE

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

(2008) Lei Yang et al.   NATURE

Progress and prospects in rat genetics: a community view

(2008) Timothy J Aitman et al.   NATURE GENETICS

Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos

(2008) Chetana Sachidanandan et al.   PLoS One

On the Mechanics of Cardiac Function of Drosophila Embryo

(2008) Mingming Wu et al.   PLoS One

A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

(2008) K. Lage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution magnetic resonance histology of the embryonic and neonatal mouse: A 4D atlas and morphologic database

(2008) A. E. Petiet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Signature of Cardiomyocyte Clusters Derived from Human Embryonic Stem Cells

(2008) Jane Synnergren et al.   STEM CELLS

Cardiovascular Assessment of Fetal Mice by In Utero Echocardiography

(2008) Qing Yu et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System

(2008) Neil C Chi et al.   PLOS BIOLOGY

Genomic chart guiding embryonic stem cell cardiopoiesis

(2008) Randolph S Faustino et al.   GENOME BIOLOGY