Article
Polymer Science
Balakondareddy Sana, Nancy Ferrentino, Taha Behroozi Kohlan, Yaqun Liu, Valdas Pasiskevicius, Anna Finne-Wistrand, Daniela Pappalardo
Summary: We have designed a light-sensitive polymer material that self-assembles into core-shell nanoparticles and releases encapsulated fluorescent dye upon light irradiation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Prasong Srihanam, Wiriya Thongsomboon, Yodthong Baimark
Summary: The aim of this study was to modify PLLA-b-PEG-b-PLLA copolymer using low-cost CaCO3 filler to improve its material properties. The addition of CaCO3 enhanced the crystallinity and thermal stability of PLLA-b-PEG-b-PLLA matrix. SEM analysis showed stronger interfacial adhesion between PLLA-b-PEG-b-PLLA and CaCO3 compared to PLLA and CaCO3. Tensile testing revealed increased stress and modulus for PLLA-b-PEG-b-PLLA matrix with CaCO3, while these properties significantly decreased for PLLA matrix. Therefore, CaCO3 shows promise as an inexpensive filler for improving PLLA-b-PEG-b-PLLA bioplastics.
Article
Engineering, Environmental
Venkanna Azmeera, Ujjal Haldar, Saswati Ghosh Roy, Tota Rajasekhar, Priyadarsi De
Summary: The study presents a method for preparing amphiphilic block copolymers containing biocompatible and biodegradable segments, synthesized through metal-free ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization of ε-caprolactone and amino acid-based acrylate monomers. The resulting block copolymers exhibit pH-responsive properties and self-assembling behavior after the deprotection of Boc groups under acidic conditions.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Polymer Science
Prasong Srihanam, Yaowalak Srisuwan, Theeraphol Phromsopha, Apirada Manphae, Yodthong Baimark
Summary: In this study, the phase compatibility and mechanical properties of flexible poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA)/thermoplastic starch (TPS) blends were improved by adding citric acid (CA) as a compatibilizer. The crystallinity of PLLA-PEG-PLLA matrix was suppressed and the thermal stability was enhanced by CA modification of TPS. The compatibility between TPS and PLLA-PEG-PLLA phases was improved, and the blends exhibited increased tensile strength, elongation at break, and Young's modulus with higher CA content.
Article
Engineering, Chemical
Mun Suk Seong, Hyun Jung Yu, Seong Yong Ha, Won Seok Chang, Hyung-Ju Kim, Jong Suk Lee
Summary: In this study, highly CO2-permeable membranes were obtained by blending micellar-structured poly(poly(ethylene glycol) methyl ether acrylate) (PPEGMEA) with poly(ether-block-amide) (Pebax). The blend membrane showed a significant enhancement in CO2 permeability while maintaining good CO2 selectivity and long-term separation performance.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Polymer Science
Xing Li, Wenqing Xu, Xiaohua Chang, Ying Zheng, Lingling Ni, Guorong Shan, Yongzhong Bao, Pengju Pan
Summary: This study reports on the controlled synthesis, stepwise crystallization kinetics, and crystallization-induced microphase separation and structural evolution of a novel end-functionalized supramolecular polymer PCL-Thy. The double-crystalline nature of PCL-Thy was observed, with thymine units and PCL blocks crystallizing and melting in a sequential manner. This work provides important insights into crystallization-induced microphase separation and hierarchical ordering in double-crystalline supramolecular polymers.
Article
Polymer Science
Honggang Mei, Bingjie Zhao, Yuan Gao, Lei Li, Liyue Liu, Sixun Zheng
Summary: This contribution presents a novel synthesis method for block copolymer networks composed of PCL and PE. The materials exhibit phase-separated morphology and shape memory properties. The combination of PCL with PE results in triple shape memory properties, triggered by the melting and crystallization of PCL and PE blocks.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Li Wan, De Qing Liang
Summary: Amphiphilic block copolymers (PVCap-b-PCL) containing different ratio of PCL and PVCap were synthesized and showed better performance than PVCap in methane hydrate inhibition experiments, providing longer induction time. These copolymers have potential as environmentally friendly hydrate inhibitors by adjusting the ratio of PCL to PVCap.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Polymer Science
Jing Wang, Jiaqi Si, Junwei Zhu, Yiqing Nie, Yan Lu, Yongming Chen
Summary: A series of crystalline-coil block copolymers with different block ratios were synthesized to explore the impact of polymer compositions on self-assembly morphologies. The copolymers were found to self-assemble into various morphologies including lozenges, quadrilaterals, elongated hexagons, hexagonal platelets, saw blade platelets, and spindle micelles. Adjusting block ratios of the copolymers is a facile way to construct diverse morphologies of polymer materials.
Article
Chemistry, Multidisciplinary
Marvin Langlais, Nicolas Baulu, Severin Dronet, Charlotte Dire, Francois Jean-Baptiste-dit-Dominique, David Albertini, Franck D'Agosto, Damien Montarnal, Christophe Boisson
Summary: Block copolymers based on polyethylene (PE) and ethylene butadiene rubber (EBR) were synthesized using successive controlled coordinative chain transfer polymerization (CCTP). By employing a complex of {Me2Si(C13H8)(2)Nd(BH4)(2)Li(THF)}2 and n-butyl, n-octyl magnesium (BOMAG) as the alkylating and chain transfer agent (CTA), EBR-b-PE diblock copolymers were obtained. Furthermore, triblock and multiblock copolymers featuring highly semi-crystalline PE hard segments and soft EBR segments were synthesized with the development of a bimetallic CTA, pentanediyl-1,5-di(magnesium bromide) (PDMB). These new block copolymers form lamellar structures through crystallization-driven organization and exhibit various mechanical properties, including excellent extensibility and elastic recovery for triblock and multiblock copolymers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Andrew Chung, Burak Tavsanli, Elizabeth R. Gillies
Summary: Hydrogels have diverse applications, and OPF has attracted attention for its tunable degradation. By introducing protected amines into OPF, the degradation rate can be controlled by triggering the cleavage of the polymer backbone. This approach can be applied to other stimuli, providing a versatile method to control OPF degradation.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Yuandou Wang, Shuxin Wang, Wenju Hu, Feng Su, Fusheng Liu, Suming Li
Summary: Amphiphilic block copolymers were synthesized and photo-crosslinked hydrogels were prepared. The hydrogels exhibited high swelling and excellent biocompatibility. Drug loading efficiency and release rate were dependent on the hydrogel properties. Hydrogels with higher drug concentration and shorter hydrophobic block length showed higher anti-cancer activity. Therefore, these hydrogels have great potential for long-term local cancer therapy.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Chunliang Zhang, Qian Xie, Ruitao Cha, Li Ding, Liujun Jia, Lei Mou, Shiyu Cheng, Nuoxin Wang, Zulan Li, Yang Sun, Chuanjue Cui, Yu Zhang, Yan Zhang, Fengshan Zhou, Xingyu Jiang
Summary: Bilayer anticoagulant hydrogel tubes with inner layer containing NFC/PVA-heparin/poly-L-lysine nanoparticles and outer layer made of PCL sheaths were prepared and studied for use as small-diameter vascular grafts. The tubes exhibited prominent anticoagulation, sufficient burst pressure, good compliance, and potential for host cell infiltration and proliferation. The structure, anticoagulant property, and biocompatibility of the inner layer, as well as the impact of outer layer thickness on tube performance and mechanical properties, were investigated. The tissue compatibility and patency of the tubes were evaluated through implantation in animal models.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Osman Yusuf, Raisuddin Ali, Abdullah H. Alomrani, Aws Alshamsan, Abdullah K. Alshememry, Abdulaziz M. Almalik, Afsaneh Lavasanifar, Ziyad Binkhathlan
Summary: This study synthesized biodegradable block copolymers based on TPGS-block-poly(epsilon-caprolactone) for a nanodelivery system, demonstrating that TPGS copolymers with PEG molecular weights >= 2000 Da can self-assemble into nanocarriers and enhance the solubility of PAX. Among the formulations, TPGS(5000)-b-PCL15000 showed the slowest in vitro release of PAX, indicating potential for efficient solubilization and controlled release.
Article
Materials Science, Multidisciplinary
Jisu Hong, Yonghwan Kwon, Min Sang Kwon, Chaenyung Cha
Summary: This paper presents a brush copolymer, P(AzPEG), as a multifunctional polymeric cross-linker for carboxylate-containing acrylic adhesives. The density and length of the AzPEG brush can be conveniently controlled to effectively regulate the mechanical and adhesive properties of the adhesive without significant changes in concentration.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yuanhao Wu, Yuan Yao, Jiamin Zhang, Han Gui, Jinjian Liu, Jianfeng Liu
Summary: A double-network nanocomposite hydrogel with persistent photothermal and radioactive effects has been developed, which can inhibit tumor recurrence and treat infections.
Article
Chemistry, Multidisciplinary
Zhilong Wang, Cuihong Yang, Hao Zhang, Yang Gao, Meng Xiao, Zhongyan Wang, Lijun Yang, Jiamin Zhang, Chunhua Ren, Jianfeng Liu
Summary: A self-delivery nanomedicine was developed to restore the Hippo pathway and inhibit tumor growth and metastasis in a TNBC model. The nanomedicine transformed from inactive nanospheres to active nanofibers in situ and activated the Hippo pathway by targeting different upstream and downstream factors. The expression of YAP and growth-promoted genes was significantly reduced, leading to suppressed proliferation and metastasis of cancer cells. Additionally, the Hippo pathway restoration showed a radiosensitization effect and synergistically enhanced the anticancer effect of radiotherapy in vivo.
Article
Biochemistry & Molecular Biology
Dan Wang, Hui Li, Dianyu Wang, Yusen Hao, Han Gui, Jianfeng Liu, Yumin Zhang, Jinjian Liu, Cuihong Yang
Summary: A coassembled hydrogel that can cascade release ROS/NO/RNS and strengthen antitumor T cell responses has been developed, which significantly improves the efficacy of immune checkpoint blockade therapy in photodynamic therapy. Reprogramming of tumor-associated macrophages (TAMs) further alleviates the immunosuppressive situation in the tumor microenvironment.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Hongmei Cao, Yang Gao, Haixue Jia, Liping Zhang, Jinjian Liu, Ganen Mu, Han Gui, Yuebing Wang, Cuihong Yang, Jianfeng Liu
Summary: Sepsis is a life-threatening disease with high morbidity and mortality. Antibiotic therapy is challenged by impaired macrophages and drug-resistant bacteria. In this study, a membrane-camouflaged metal-organic framework system was developed for efficient delivery of plasmid DNA to combat sepsis, significantly improving the survival rate of septic mice.
Article
Engineering, Biomedical
Zujian Feng, Yumin Zhang, Chunfang Yang, Xiang Liu, Yini Huangfu, Chuangnian Zhang, Pingsheng Huang, Anjie Dong, Jinjian Liu, Jianfeng Liu, Deling Kong, Weiwei Wang
Summary: A glycopeptide hydrogel inspired by extracellular matrix (ECM) has been designed to accelerate wound healing in radiation-induced skin injury (RSI) by modulating chronic inflammation. The hydrogel replicates ECM components and structure, scavenges reactive oxygen species (ROS), and polarizes macrophages to reduce inflammation. In mouse models, the hydrogel significantly reduces hyperplasia, promotes regeneration and angiogenesis, and decreases proinflammatory cytokine expression, making it superior to current treatment options.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yang Gao, Yun Li, Hongmei Cao, Haixue Jia, Dianyu Wang, Chunhua Ren, Zhongyan Wang, Cuihong Yang, Jianfeng Liu
Summary: A self-assembled peptide derivative (NSBSO) based on BSO was developed to selectively deplete tumor GSH and inhibit its biosynthesis, leading to ferroptosis and pyroptosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shi-Qi Dong, Fan Yang, Dong-Xu Zhang, Ling-Mei Wang, Jian-Feng Liu, Ai-Jie Zhang, Hui-Rong Fan
Summary: The study investigated the effects of X-ray radiation on the pharmacokinetics of apatinib in rats and found that radiation decreased plasma exposure, tissue distribution, and excretion of apatinib. This phenomenon may be closely related to changes in metabolic enzymes in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lijun Yang, Dianyu Wang, Haixue Jia, Cuihong Yang, Yumin Zhang, Hui Li, Jinjian Liu, Jianfeng Liu
Summary: Tumor cells use metabolic reprogramming to create an immunosuppressive tumor microenvironment (TME) and evade the immune system. This study develops a tumor-specific peroxynitrite nanogenerator that disrupts metabolic homeostasis in melanoma cells. The produced peroxynitrite induces a decrease in metabolites in the tricarboxylic acid cycle and reduces lactate production. Mechanistically, peroxynitrite impairs glucose metabolism by affecting the activity of glyceraldehyde-3-phosphate dehydrogenase. These metabolic alterations reverse the immunosuppressive TME and promote antitumor immune responses. When combined with anti-PD-L1, the nanogenerator inhibits both primary and metastatic melanomas without causing toxicity. This research provides a new strategy for enhancing immunotherapy sensitivity.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren, Jianfeng Liu
Summary: A surface-induced self-assembly system (CA-Pt) is developed to overcome hypoxic cancer stem cell-mediated radioresistance by deep penetration, amplified CAIX inhibition, and enhanced cellular uptake. It effectively relieves the hypoxic and acidic microenvironment, promotes the differentiation of hypoxic CSCs, and enhances the DNA damage induced by radiotherapy. This study provides a universal treatment strategy for overcoming tumor radioresistance.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Yusen Hao, Hui Li, Jiajun Guo, Dan Wang, Jiamin Zhang, Jinjian Liu, Cuihong Yang, Yumin Zhang, Guoliang Li, Jianfeng Liu
Summary: Radiotherapy is an important cancer treatment method, but it can cause adverse reactions and injuries to the skin. This study designed an antioxidant heparin-mimetic peptide hydrogel (K16) for repairing radiation-induced skin injuries (RISI). The K16 hydrogel can scavenge excess reactive oxygen species (ROS), prevent radiation damage to DNA, promote cell proliferation, migration, and angiogenesis, and eliminate inflammation at the wound site. In vivo experiments demonstrated that the K16 hydrogel inhibits wound degradation, reduces inflammation, and promotes wound healing. Therefore, the K16 hydrogel has great potential for application in repairing radiation-induced skin injuries.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Hongjing Luo, Hongmei Cao, Haixue Jia, Yuna Shang, Jinjian Liu, Han Gui, Cuihong Yang, Chunhua Ren, Zhongyan Wang, Jianfeng Liu
Summary: Radiotherapy can remodel the tumor microenvironment by inducing immunogenic cell death and inflammation, but it is not effective in generating a systemic antitumor immune response. This study presents a novel strategy to create in situ peptide-based nanovaccines using enzyme-induced self-assembly, in combination with immunogenic cell death. The nanovaccine enhances antigen accumulation in the lymph nodes and cross-presentation by antigen-presenting cells, and promotes the repolarization of macrophages and reduces regulatory T cells and myeloid-derived suppressor cells. The combination of nanovaccines and radiotherapy significantly improves the therapeutic effect on tumors, providing a promising strategy for tumor radioimmunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhongyan Wang, Yuna Shang, Hongjing Luo, Cuihong Yang, Zhimou Yang, Chunhua Ren, Jianfeng Liu
Summary: This study presents a novel strategy of achieving higher hierarchical structures through cooperative self-assembly of hydrophobic tripeptides with reverse sequences, showing a low-to-high hierarchical structure transformation. The cooperation between different sequences also allows different morphological transitions, promoting a more compact molecular arrangement by creating more hydrogen bond interactions and in-register π-π stacking in the anti-parallel β-sheet conformation. This work provides a handy approach for controlled hierarchical assembly and the development of various functional bionanomaterials.
Article
Chemistry, Multidisciplinary
Qian Wang, Hongmei Cao, Xiaoxue Hou, Dianyu Wang, Zhilong Wang, Yue Shang, Shuqin Zhang, Jinjian Liu, Chunhua Ren, Jianfeng Liu
Summary: This study reports a CAIX-targeted induced in situ self-assembly system on the surface of hypoxic cancer stem-like cells (CSCs), which relieves the hypoxic and acidic microenvironment and promotes CSC differentiation to overcome tumor radiotherapy resistance. The constructed peptide-based drug delivery system exhibits deep penetration, amplified CAIX inhibition, and enhanced cellular uptake, showing potential as a universal treatment strategy for overcoming tumor radioresistance.
ADVANCED MATERIALS
(2023)
Retraction
Polymer Science
Minjie Tang, Zheng Yang, Zujian Feng, Junhui Zhou, Jinjian Liu, Jianfeng Liu, Weiwei Wang, Junqiang Zhao, Anjie Dong, Liandong Deng
Article
Engineering, Biomedical
Guang Yang, Da-Yuan Wang, Yong Liu, Fan Huang, Shuang Tian, Yijin Ren, Jianfeng Liu, Yingli An, Henny C. van der Mei, Henk J. Busscher, Linqi Shi
Summary: This study developed a magnetic cascade-reaction container that can generate reactive-oxygen-species for eradicating infectious biofilms. In vitro experiments showed that cascade-reaction containers with coupled glucose-oxidase were effective in killing various bacteria. In vivo experiments demonstrated that cascade-reaction containers could accumulate in abdominal Staphylococcus aureus biofilms in real-time through magnetic targeting. Furthermore, the study found that vancomycin-resistant abdominal S. aureus biofilms could be eradicated using endogenous glucose.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
