Hypertoxic self-assembled peptide with dual functions of glutathione depletion and biosynthesis inhibition for selective tumor ferroptosis and pyroptosis

Tumor microenvironments self-activated nanoscale metal organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy

(2021) Yu Liang et al.   Acta Pharmaceutica Sinica B

Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy

(2021) Xiaotong Cheng et al.   ACS Nano

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy

(2021) Xiaoyan Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

(2021) Boyi Niu et al.   BIOMATERIALS

Cancer immunogenic cell death via photo-pyroptosis with light-sensitive Indoleamine 2,3-dioxygenase inhibitor conjugate

(2021) Yang Lu et al.   BIOMATERIALS

Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer

(2021) Xiang Pan et al.   JOURNAL OF NANOBIOTECHNOLOGY

A Glutathione Activatable Ion Channel Induces Apoptosis in Cancer Cells by Depleting Intracellular Glutathione Levels

(2020) Javid Ahmad Malla et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transformable peptide nanoparticles inhibit the migration of N-cadherin overexpressed cancer cells

(2020) Jiaqi Fan et al.   CHINESE CHEMICAL LETTERS

Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapy

(2020) Zhifei Cheng et al.   Nano Today

Selectively enhancing radiosensitivity of cancer cells via in situ enzyme-instructed peptide self-assembly

(2020) Yang Gao et al.   Acta Pharmaceutica Sinica B

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transformable Dual‐Inhibition System Effectively Suppresses Renal Cancer Metastasis through Blocking Endothelial Cells and Cancer Stem Cells

(2020) Lu Wang et al.   Small

In vivo self-assembled nanomedicine

(2020) Muhetaerjiang Mamuti et al.   Nano Today

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors

(2019) Li Tan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Assemblies of Peptides in Complex Environment and Their Applications

(2019) Bing Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme‐Instructed Self‐Assembly (EISA) and Hydrogelation of Peptides

(2019) Jie Gao et al.   ADVANCED MATERIALS

GSH-responsive anti-mitotic cell penetrating peptide-linked podophyllotoxin conjugate for improving water solubility and targeted synergistic drug delivery

(2019) Jia Wen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer

(2019) Qian Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy

(2019) Yue Yuan et al.   NATURE MATERIALS

Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy

(2018) Guo-Bin Qi et al.   ADVANCED MATERIALS

Tandem Molecular Self-Assembly in Liver Cancer Cells

(2018) Jie Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

(2018) Nathalia M. de Vasconcelos et al.   CELL DEATH AND DIFFERENTIATION

Nitric oxide as an all-rounder for enhanced photodynamic therapy: Hypoxia relief, glutathione depletion and reactive nitrogen species generation

(2018) Yongyan Deng et al.   BIOMATERIALS

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy

(2018) Ziliang Dong et al.   NANO LETTERS

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells

(2016) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

(2016) Ran Mo et al.   Materials Today

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Controlled Intracellular Self-Assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish

(2014) Yue Yuan et al.   ACS Nano

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

A supramolecular hydrogelator of curcumin

(2014) Chengbiao Yang et al.   CHEMICAL COMMUNICATIONS

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

A structure–gelation ability study in a short peptide-based ‘Super Hydrogelator’ system

(2011) Huaimin Wang et al.   Soft Matter

Enzyme-triggered self-assembly of a small molecule: a supramolecular hydrogel with leaf-like structures and an ultra-low minimum gelation concentration

(2010) Huaimin Wang et al.   NANOTECHNOLOGY

Enzymatic Hydrogelation of Small Molecules

(2008) Zhimou Yang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE