Article
Chemistry, Applied
K. M. Kanyuck, T. B. Mills, I. T. Norton, A. B. Norton-Welch
Summary: This study investigated the swelling mechanism of high acyl gellan gum, its impact on hydrogel mechanical properties and drug release. Low ionic strength solutions caused the highest degree of swelling and slowed down glucose release, highlighting the importance of considering these changes in formulation design for functional applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Biomedical
Piotr Gadzinski, Tomasz Zbigniew Osmalek, Anna Froelich, Oliwia Wilmanska, Agata Nowak, Adam Tatarek
Summary: The purpose of this study was to investigate the rheological and textural parameters of gellan-based hydrogels and their dependence on various factors. The results showed that rheological analysis was more precise and sensitive in measuring the mechanical properties of the gels.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Review
Pharmacology & Pharmacy
Piotr Gadzinski, Anna Froelich, Barbara Jadach, Monika Wojtylko, Adam Tatarek, Antoni Bialek, Julia Krysztofiak, Michal Gackowski, Filip Otto, Tomasz Osmalek
Summary: Hydrogels, such as gellan gum, have a tridimensional structure and can absorb water or fluids without losing their structure. They can be used for encapsulation and targeted drug release. Gellan gum has unique features and is non-toxic, biocompatible, and biodegradable. Chemical crosslinking can modify the properties of gellan gum hydrogels and improve their three-dimensional structure.
Article
Biochemistry & Molecular Biology
Seyed Saeed Mousavi, Hamid Keshvari, Hamed Daemi
Summary: This study demonstrates that partial sulfation of Gellan gum (GG) can produce a cytocompatible temperature-responsive hydrogel. The resulting hydrogel shows an interesting thermoreversibility at 42°C and a drop in mechanical properties can be compensated by further calcium-mediated ionic crosslinking.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Nitin Rajendra Shirsath, Ajaygiri Kamalgiri Goswami
Summary: The research focused on designing and optimizing Vildagliptin-loaded gellan gum beads for sustained drug release, utilizing response surface methodology to determine the effects of independent variables on dependent variables. The prepared beads exhibited high entrapment efficiency and drug release, as well as pH-dependent swelling and mucoadhesivity.
MATERIALS TECHNOLOGY
(2021)
Review
Chemistry, Applied
D. Gomes, J. P. Batista-Silva, A. Sousa, L. A. Passarinha
Summary: Gellan gum, a biodegradable microbial exopolysaccharide, has potential applications in various fields such as food, pharmacy, biomedicine, and tissue engineering. Researchers have utilized the hydroxyl and carboxyl groups in each repeating unit to improve the properties of gellan gum, leading to significant advancements in the design of gellan-based materials.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Bing Cui, Di Wu, Bin Zhou, Kongdi Zhu, Yaqiong Pei, Bin Li, Hongshan Liang
Summary: This paper proposes a method utilizing hydrogel to regulate crystal growth, using nobiletin (NOB) as a model. The results showed that the NOB crystallization was controlled by gellan gum (GG) concentrations and the ratios of GG to NaCl. The study also investigated the texture and rheological properties of GG-NOB composite gels, and found that the final composite gels exhibited sustained release properties and significantly improved release efficiency.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Applied
Tian-Qi Zhou, Xue-Chen Wang, Ling-Yi Gao, Jia-Nan Yan, Hai-Tao Wu
Summary: This study investigated the synergetic gelation of curdlan gum (CG) and gellan gum (GG) at different ratios. The optimal gelation was achieved at a mass ratio of 1:1 and a total concentration of 0.6%. The gel properties were influenced by the CG/GG ratio, with the strongest gel observed at a ratio of 5:5. The improved gel properties were attributed to hydrogen bonds between CG and GG. The CG/GG binary composite gel exhibited increased water holding capacity as the CG/GG ratio decreased. Furthermore, the microstructure of the CG/GG gel was denser and more homogeneous, supporting its stronger gel rigidity and water holding capacity.
FOOD HYDROCOLLOIDS
(2024)
Article
Polymer Science
Yesica Vanesa Rojas-Munoz, Patricio Roman Santagapita, Maria Ximena Quintanilla-Carvajal
Summary: This study evaluated the effect of wall materials on the viability of Lactobacillus fermentum during the encapsulation process and under simulated gastrointestinal conditions. The optimal mixture formulation was determined, and its effectiveness in improving bacterial survival was confirmed through experiments and modeling.
Article
Polymer Science
Calogero Fiorica, Giuseppina Biscari, Fabio Salvatore Palumbo, Giovanna Pitarresi, Annalisa Martorana, Gaetano Giammona
Summary: A series of four different low molecular weight gellan gum products were obtained by alkaline hydrolysis to investigate their impact on rheological properties and physicochemical characteristics of ionotropic crosslinked hydrogels. Thermo-rheological analysis and strain sweep experiments were used to study the properties of the polysaccharide aqueous dispersions. The effect of different Ca2+ ions on the rheological properties of hydrogels, as well as their morphology, swelling behavior, and viscoelastic properties, were also studied.
Article
Pharmacology & Pharmacy
Shazia Noureen, Sobia Noreen, Shazia Akram Ghumman, Fozia Batool, Huma Hameed, Sara Hasan, Fozia Noreen, Mervat A. Elsherif, Syed Nasir Abbas Bukhari
Summary: This study focused on formulating Prunus armeniaca gum (PAG) and sodium alginate microspheres for sustained drug release, demonstrating that blending PAG with sodium alginate can enhance the stability of alginate microspheres and improve its drug release profile by prolonging the release time.
Article
Chemistry, Applied
Zhiping Fan, Ping Cheng, Yan Gao, Dawei Wang, Guangwei Jia, Pan Zhang, Sangeeta Prakash, Zhengping Wang, Jun Han
Summary: This research highlights the engineering of novel composite hydrogels from natural polysaccharides Salecan and Gellan using physical methods, without any structural modification or chemical crosslinking. The rheological properties of the hydrogels were investigated and key parameters were explored and compared using different models like Power Law, Herschel-Bulkley, and Arrhenius. This study reports the development of a novel composite hydrogel with ideal elasticity, injectability, good thermostability, and self-recovery, paving the way for its application in various fields.
FOOD HYDROCOLLOIDS
(2022)
Article
Biochemistry & Molecular Biology
Maryam Sahraro, Mehdi Barikani, Hamed Daemi, Payam Baei
Summary: In this study, multifunctional polyurethane nanoparticles (MPUNs) were embedded into methacrylated gellan gum to prepare stimuli-responsive hydrogels with improved mechanical properties. The optimized formulation showed excellent compression strength and ultimate strain, as well as the ability to restore its original shape after repeated compression tests. The hydrogels exhibited a dual physical and chemical crosslinking mechanism and were found to be non-toxic to human dermal fibroblast cells, making them suitable for soft tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Linyuan Liu, Duoduo Zhang, Xiaoxiao Song, Mi Guo, Ziwei Wang, Fang Geng, Xingtao Zhou, Shaoping Nie
Summary: In this study, the encapsulation of anthocyanins with Gelatin/Gellan gum was investigated to protect anthocyanins from degradation in the stomach and enhance their release in the small intestine. The results showed that Gelatin/Gellan gum = 8/2 had the most compact and stable structure, and the compound hydrogels did not inhibit the proliferation of normal rat intestinal epithelial cells (IEC-6), indicating the effectiveness and safety of this method.
FOOD HYDROCOLLOIDS
(2022)
Article
Biochemistry & Molecular Biology
Peng Wang, Zhi-gang Luo, Zhi-gang Xiao, Ahmed S. M. Saleh
Summary: Oxidized gellan gum (OGG) hydrogel beads were used as delivery systems for resveratrol. The degree of oxidation (DO) and CaCl2 concentration had significant effects on the formation and functional properties of hydrogel beads. The resveratrol encapsulation efficiency and loading capacity of OGG hydrogel beads increased with higher DO. The hydrogel beads showed a uniform spherical shape and were formed through hydrogen bonds and ionic interaction. Encapsulation of resveratrol changed its physical state from crystalline to amorphous form. Hydrogel beads fabricated with DO80 OGG and 1.0 M CaCl2 provided high protection and maintained the antioxidant capacity of resveratrol. DO and CaCl2 concentrations controlled the in-vitro release behaviors of hydrogel beads and achieved targeted release of resveratrol in the small intestine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Somasree Ray, Pratyusha Sinha, Bibek Laha, Sabyasachi Maiti, Uttam Kumar Bhattacharyya, Amit Kumar Nayak
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Chemistry, Applied
Bibek Laha, Rimpa Goswami, Sabyasachi Maiti, Kalyan Kumar Sen
CARBOHYDRATE POLYMERS
(2019)
Article
Biophysics
Bibek Laha, Sanjib Das, Sabyasachi Maiti, Kalyan Kumar Sen
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Manabendra Dhua, Sabyasachi Maiti, Kalyan Kumar Sen
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Review
Chemistry, Applied
Biswajit Maji, Sabyasachi Maiti
Summary: Xanthan gum-based graft copolymers can enhance the removal efficiency of toxic heavy metals and synthetic dyes, and also have controlled drug release properties. Further research in polysaccharide studies and exploration of new materials are of significant importance.
CARBOHYDRATE POLYMERS
(2021)
Review
Pharmacology & Pharmacy
Shivani Rai Paliwal, Rameshroo Kenwat, Sabyasachi Maiti, Rishi Paliwal
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Chemistry, Applied
Manabendra Dhua, Kalyan Kumar Sen, Sabyasachi Maiti
Summary: The properties of polysaccharide-based hydrogels can be modified by developing an interpenetrating polymer network (IPN) for controlled drug delivery. This study found that a viscous, highly carboxylated xanthan (CX) gum could serve as an additive in the design of IPN hydrogel beads, effectively controlling drug release in simulated gastrointestinal conditions.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hemant Ramachandra Badwaik, Leena Kumari, Sabyasachi Maiti, Kalyani Sakure, Tapan Kumar Ajazuddin
Summary: This review discusses the properties and issues of natural gums, as well as the research and applications of carboxymethylation. The article provides detailed information on the application of carboxymethyl gums as drug delivery carriers and briefly introduces their potential in tissue engineering and cell delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Jwala Patel, Sabyasachi Maiti, N. S. Hari Narayana Moorthy
Summary: In this study, repaglinide-loaded hydrogel particles were successfully fabricated using carboxyethyl xanthan gum and carboxymethyl xanthan gum. The controlled drug delivery performance of these particles was evaluated, and it was found that acetylated hydrogel particles exhibited high drug entrapment efficiency and extended drug release, which could effectively control diabetes.
CARBOHYDRATE POLYMERS
(2022)
Review
Pharmacology & Pharmacy
Harsh Yadav, Reshu Agrawal, Anupama Panday, Jwala Patel, Sabyasachi Maiti
Summary: Silicate-polysaccharide composite systems have unique chemical and physical characteristics that improve material properties and drug release kinetics. By adding silicates to the composite matrices, the swelling, erosion, and dissolving behavior can be controlled, allowing for greater control of drug loading capacity and release profiles. A clear understanding of this composite system is crucial for designing new drug release carriers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Chemical
Jwala Patel, N. S. Hari Narayana Moorthy, Sabyasachi Maiti
Summary: This investigation developed semi-interpenetrating polymer network hydrogel particles using Moi gum and carboxymethyl xanthan gum, and found promising drug release performance and preclinical anti-diabetic activity.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Polymer Science
Anupama Panday, Harsh Yadav, Jwala Patel, Rishi Paliwal, Sabyasachi Maiti
Summary: This study focused on the synthesis and characterization of alginate-gellan gum composite IPN and IPN hydrogel microspheres for controlled drug delivery. The internal cross-linking of the polymer sol was achieved through the slow release of Ca2+ ions from calcium silicate in the presence of gluconic acid d-lactone. The microspheres showed a spherical shape with a smooth surface morphology and had a high drug entrapment efficiency of 70%-76%.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Harsh Yadav, Sabyasachi Maiti
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Review
Chemistry, Multidisciplinary
Jwala Patel, Biswajit Maji, N. S. Hari Narayana Moorthy, Sabyasachi Maiti
Proceedings Paper
Materials Science, Multidisciplinary
Bibek Laha, Sabyasachi Maiti
MATERIALS TODAY-PROCEEDINGS
(2019)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
