Journal
CARBOHYDRATE POLYMERS
Volume 259, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117758
Keywords
Gellan gum; Swelling; Drug release; Gellan hydrogel; Tissue scaffold; Superabsorbent hydrogel
Categories
Funding
- Engineering and Physical Sciences Research Council [EP/K030957/1]
- EPSRC Centre for Innovative Manufacturing in Food
- EPSRC [EP/K030957/1] Funding Source: UKRI
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This study investigated the swelling mechanism of high acyl gellan gum, its impact on hydrogel mechanical properties and drug release. Low ionic strength solutions caused the highest degree of swelling and slowed down glucose release, highlighting the importance of considering these changes in formulation design for functional applications.
This study examined the mechanism of swelling for high acyl (HA) gellan gum and the impacts on the hydrogel mechanical properties and the release of a model drug (glucose). Controlling the material properties and the release of entrapped drugs during use in aqueous environments, such as the stomach or bodily fluids, are crucial in designing functional applications. Swelling of HA gellan gum was controlled by varying the osmotic environment with salts and solvents, and effects on the gel network were characterized by uniaxial compression tests, DSC, and rheology. Low ionic strength solutions caused the greatest degree of swelling (up to 400 %) and corresponded to a more brittle gel with a greater modulus and greater network enthalpy. Swelling slowed the release of glucose by decreasing the diffusion flux. The osmotic environment was found to produce different functional properties, and it is crucial to consider these changes in the design of formulations.
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