Wnt signaling in human and mouse breast cancer: Focusing on Wnt ligands, receptors and antagonists

R-spondin3 is associated with basal-progenitor behavior in normal and tumor mammary cells

(2018) Johanna Melisa Tocci et al.   CANCER RESEARCH

PDGFRα+pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

(2018) Gediminas Greicius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Advances in Lgr5 + Stem Cell Research

(2018) Carly Leung et al.   TRENDS IN CELL BIOLOGY

Role of Wnt Co-Receptor LRP6 in Triple Negative Breast Cancer Cell Migration and Invasion

(2017) Jinlu Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent

(2017) Erik Hedrick et al.   MOLECULAR AND CELLULAR BIOLOGY

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis

(2017) Michael Sigal et al.   NATURE

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

(2017) Kelley S. Yan et al.   NATURE

Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1

(2017) Xueqian Zhuang et al.   NATURE CELL BIOLOGY

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion

(2017) Anders Sundqvist et al.   NUCLEIC ACIDS RESEARCH

Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b

(2017) Y Chen et al.   ONCOGENE

FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer

(2017) Bingchen Han et al.   ONCOGENE

MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

(2017) Cong Lv et al.   Nature Communications

Neuropilin-1 is upregulated by Wnt/β-catenin signaling and is important for mammary stem cells

(2017) Wei Liu et al.   Scientific Reports

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

γ-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is associated with inhibition of canonical Wnt signalling

(2016) R. A. Ahmed et al.   CELL PROLIFERATION

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer

(2016) Gabriele Corda et al.   JOURNAL OF PATHOLOGY

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

(2016) Alexandra Avgustinova et al.   Nature Communications

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling

(2015) Lu Yang et al.   STEM CELLS

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Identification of multipotent mammary stem cells by protein C receptor expression

(2014) Daisong Wang et al.   NATURE

Role of the protein C receptor in cancer progression

(2014) Wolfram Ruf et al.   THROMBOSIS RESEARCH

BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10

(2014) Chang Gong et al.   Nature Communications

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Targeting ROR1 Inhibits Epithelial-Mesenchymal Transition and Metastasis

(2013) B. Cui et al.   CANCER RESEARCH

WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer

(2013) Peter Wend et al.   EMBO Molecular Medicine

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

(2013) Vicki Plaks et al.   Cell Reports

Mammary Tumor Regression Elicited by Wnt Signaling Inhibitor Requires IGFBP5

(2012) B. Y. Liu et al.   CANCER RESEARCH

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

(2012) Karin E de Visser et al.   JOURNAL OF PATHOLOGY

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype

(2011) S. Ricardo et al.   JOURNAL OF CLINICAL PATHOLOGY

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

FZD7 has a critical role in cell proliferation in triple negative breast cancer

(2011) L Yang et al.   ONCOGENE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis

(2010) F. Klemm et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression

(2010) Douglas S. Micalizzi et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

(2009) Theresa A. DiMeo et al.   CANCER RESEARCH

Wnt signaling activation and mammary gland hyperplasia in MMTV–LRP6 transgenic mice: implication for breast cancer tumorigenesis

(2009) J Zhang et al.   ONCOGENE

The Wnt Co-Receptor Lrp6 Is Required for Normal Mouse Mammary Gland Development

(2009) Charlotta Lindvall et al.   PLoS One

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

(2008) H Suzuki et al.   BRITISH JOURNAL OF CANCER

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

The Mammary Progenitor Marker CD61/ 3 Integrin Identifies Cancer Stem Cells in Mouse Models of Mammary Tumorigenesis

(2008) F. Vaillant et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Musashi1 Modulates Mammary Progenitor Cell Expansion through Proliferin-Mediated Activation of the Wnt and Notch Pathways

(2008) X.-Y. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1Murine Breast Tumors

(2007) Robert W. Cho et al.   STEM CELLS