Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties

A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis

(2013) Xinrong Ma et al.   OncoImmunology

Modulation of Host Natural Killer Cell Functions in Breast Cancer via Prostaglandin E2 Receptors EP2 and EP4

(2012) Dawn M. Holt et al.   JOURNAL OF IMMUNOTHERAPY

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-Stimulated Mesenchymal Stem Cells Create a Carcinoma Stem Cell Niche via Prostaglandin E 2 Signaling

(2012) Hua-Jung Li et al.   Cancer Discovery

Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2

(2011) Xinrong Ma et al.   BREAST CANCER RESEARCH AND TREATMENT

Prostaglandin E2 EP receptors as therapeutic targets in breast cancer

(2011) Jocelyn Reader et al.   CANCER AND METASTASIS REVIEWS

The role of the EP receptors for prostaglandin E2 in skin and skin cancer

(2011) J. E. Rundhaug et al.   CANCER AND METASTASIS REVIEWS

Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4

(2011) Dawn Holt et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Prostaglandin E2Regulates Renal Cell Carcinoma Invasion through the EP4 Receptor-Rap GTPase Signal Transduction Pathway

(2011) Juanjuan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells

(2011) Jenny A. Rudnick et al.   PLoS One

Identification of EP4 as a Potential Target for the Treatment of Castration-Resistant Prostate Cancer Using a Novel Xenograft Model

(2010) N. Terada et al.   CANCER RESEARCH

Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line

(2010) Balraj Singh et al.   JOURNAL OF SURGICAL RESEARCH

Biomarker Expression and Risk of Subsequent Tumors After Initial Ductal Carcinoma In Situ Diagnosis

(2010) K. Kerlikowske et al.   JNCI-Journal of the National Cancer Institute

Prostaglandin E2 Promotes Lung Cancer Cell Migration via EP4- Arrestin1-c-Src Signalsome

(2010) J. I. Kim et al.   MOLECULAR CANCER RESEARCH

Prostaglandin E Receptor EP1 Suppresses Breast Cancer Metastasis and Is Linked to Survival Differences and Cancer Disparities

(2010) Xinrong Ma et al.   MOLECULAR CANCER RESEARCH

Prostaglandin E2 Stimulates Human Lung Carcinoma Cell Growth through Induction of Integrin-Linked Kinase: The Involvement of EP4 and Sp1

(2009) Y. Zheng et al.   CANCER RESEARCH

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function

(2008) Namita Kundu et al.   BREAST CANCER RESEARCH AND TREATMENT

In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP4 receptor antagonist

(2007) Akio Murase et al.   LIFE SCIENCES