Pericellular pH homeostasis is a primary function of the Warburg effect: Inversion of metabolic systems to control lactate steady state in tumor cells

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

(2011) Ravinder Tammali et al.   ANGIOGENESIS

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs

(2011) Hiroko Onozuka et al.   CANCER SCIENCE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis

(2011) Christel van den Hoogen et al.   CLINICAL & EXPERIMENTAL METASTASIS

Metabolic Imaging: A Link between Lactate Dehydrogenase A, Lactate, and Tumor Phenotype

(2011) I. Serganova et al.   CLINICAL CANCER RESEARCH

MiD49 and MiD51, new components of the mitochondrial fission machinery

(2011) Catherine S Palmer et al.   EMBO REPORTS

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

Clinical applications of positron emission tomography in hepatic tumors

(2011) Susumu Shiomi et al.   HEPATOLOGY RESEARCH

Mitochondrial Dysfunction in Cancer Cells Due to Aberrant Mitochondrial Replication

(2011) Yuriy Shapovalov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of tumor glutamate metabolism in vivo using 13C magnetic resonance spectroscopy and hyperpolarized [1-13C]glutamate

(2011) Ferdia A. Gallagher et al.   MAGNETIC RESONANCE IN MEDICINE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins

(2011) Pinwei Huang et al.   PLoS One

Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism

(2011) Andreja Šmerc et al.   PLoS One

Molecular Crowding Defines a Common Origin for the Warburg Effect in Proliferating Cells and the Lactate Threshold in Muscle Physiology

(2011) Alexei Vazquez et al.   PLoS One

ALDH Activity Selectively Defines an Enhanced Tumor-Initiating Cell Population Relative to CD133 Expression in Human Pancreatic Adenocarcinoma

(2011) Michael P. Kim et al.   PLoS One

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the mitochondrial fusion-fission cycle and its role in aging

(2011) A. Kowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacochemistry of the platelet purinergic receptors

(2011) Kenneth A. Jacobson et al.   Purinergic Signalling

Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction

(2011) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

Genome-Scale Metabolic Modeling Elucidates the Role of Proliferative Adaptation in Causing the Warburg Effect

(2011) Tomer Shlomi et al.   PLoS Computational Biology

Signalling and pharmacological properties of the P2Y14 receptor

(2010) T. K. Harden et al.   Acta Physiologica

Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator

(2010) Richard C. Scarpulla   Annals of the New York Academy of Sciences

S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition

(2010) Annette Hayden et al.   BREAST CANCER RESEARCH AND TREATMENT

Breast cancer recurrence diagnosis suspected on tumor marker rising

(2010) Laurence Champion et al.   CANCER

In vivo MRSI of hyperpolarized [1-13C]pyruvate metabolism in rat hepatocellular carcinoma

(2010) Moses M. Darpolor et al.   NMR IN BIOMEDICINE

Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance

(2009) Jiarong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Induction of apoptosis by Hax-1 siRNA in melanoma cells

(2009) Wen-Bin Li et al.   CELL BIOLOGY INTERNATIONAL

Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27Kip1expression

(2009) Jin Sil Chung et al.   FREE RADICAL RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Study of pyruvate kinase activity in human astrocytomas - Alanine-inhibition test revisted

(2009) MN Subhash et al.   NEUROLOGY INDIA

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The anti-apoptotic protein HAX-1 is a regulator of cardiac function

(2009) W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Azacytidine causes complex DNA methylation responses in myeloid leukemia

(2008) C. Stresemann et al.   MOLECULAR CANCER THERAPEUTICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

The role of SERCA2a/PLN complex, Ca2+ homeostasis, and anti-apoptotic proteins in determining cell fate

(2008) Elizabeth Vafiadaki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY