Article
Biochemistry & Molecular Biology
Jianing Tian, Ruimin Wang, Xiao Yang, Jie Yang, Yifei Zhang, Xuan Li, Hangfei Liang, Shicheng Fan, Yue Gao, Simin Zhang, Xiangyang Qu, Min Huang, Huichang Bi
Summary: This study aimed to explore the features of spatial changes in hepatocytes during PXR-induced liver enlargement. The results showed that hepatocyte hypertrophy mainly occurred around the central vein, while hepatocyte proliferation mainly occurred around the portal vein. Furthermore, the spatial changes in hepatocyte hypertrophy and proliferation were closely associated with the regional expression of related proteins and the regional distribution of triglycerides.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Zeeshan Qureshi, Mashaal Ahmad, Wan-Xi Yang, Fu-Qing Tan
Summary: The study reveals the functional significance of KIF15 in the growth and development of prostate cancer, indicating its potential role as a novel therapeutic target for the treatment of PCa by promoting cell proliferation and inhibiting signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Min He, Yitao Wang, Jing Cai, Yan Xie, Chuntao Tao, Yuyou Jiang, Haiyu Li, Fangzhou Song
Summary: The study identified that lncRNA DLEU2 is significantly upregulated in cervical cancer tissues, promoting cell proliferation and accelerating the cell cycle. Through mechanisms such as inhibiting p53 expression, lncRNA DLEU2 may promote cell cycle progression by inhibiting the activity of the Notch signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhihu Li, So Mee Kwon, Daochuan Li, Linhao Li, Xiwei Peng, Junran Zhang, Tatsuya Sueyoshi, Jean-Pierre Raufman, Masahiko Negishi, Xin Wei Wang, Hongbing Wang
Summary: The study reveals that reduced expression of human CAR is associated with worse prognosis in hepatocellular carcinoma. Overexpression of CAR in human hepatoma cells can significantly suppress cell proliferation and growth, and affects cell growth through multiple mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Toxicology
Julie Nilles, Johanna Weiss, Walter E. Haefeli, Stephanie Ruez, Dirk Theile
Summary: This study describes idealized models for dual PXR reporter gene assays and their key features, and provides guidance to avoid experimental errors and misinterpretation of data. Experimental data support these models and highlight the importance of considering drug concentration limits, observing changes in Renilla luminescence, and evaluating the relationship between PXR activity, proliferation, and fluorescence signals.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Halima Sultana, Ayaka Kato, Ai Ohashi, Rie Takashima, Tomoko Katsurai, Shoko Sato, Masafumi Monma, Yusuke Ohsaki, Tomoko Goto, Michio Komai, Hitoshi Shirakawa
Summary: PXR acts as a key regulator of defense against foreign substances and can be activated by dietary supplements, impacting drug metabolism efficiency through interactions with drugs and nutrients.
Article
Oncology
Shayi Wu, Miao Chen, Jiao Huang, Feifei Zhang, Zhaojie Lv, Yongxu Jia, Yu-Zhu Cui, Liang-Zhan Sun, Ying Wang, Ying Tang, Krista R. Verhoeft, Yan Li, Yanru Qin, Xiang Lin, Xin-Yuan Guan, Ka-On Lam
Summary: This study reveals the upregulation of ORAI2 in lymph node metastasis of gastric cancer, and its role in cell proliferation and migration. Clinical data shows a correlation between ORAI2-positive cells in gastric cancer tissues and poor prognosis. ORAI2 promotes metastasis of gastric cancer cells through activation of PI3K/Akt signaling pathway and focal adhesion disassembly at the cell's rear-edge.
Article
Biochemistry & Molecular Biology
Joo Yeon Jeong, Haangik Park, Hong Yoo, Eun-Jin Kim, Borami Jeon, Jong Deog Lee, Dawon Kang, Changjoon Justin Lee, Sun Ha Paek, Eun Joo Roh, Gwan-Su Yi, Sang Soo Kang
Summary: Despite advances in diagnostic and therapeutic technologies, lung cancer remains a major cause of cancer-related deaths worldwide. This study explores the effects of antipsychotic drugs on non-small cell lung cancer (NSCLC). The results suggest that certain antipsychotics, including trifluoperazine (TFP) and its synthetic analogs, can inhibit the proliferation and migration of lung cancer cells, and promote apoptosis. Additionally, a synthetic TFP analog shows even stronger anticancer effects than TFP. This study provides insights into the potential of antipsychotics as a preventive and therapeutic approach for NSCLC.
Article
Pharmacology & Pharmacy
Dajana Lichtenstein, Alexandra Lasch, Jimmy Alarcan, Almut Mentz, Joern Kalinowski, Felix F. Schmidt, Oliver Poetz, Philip Marx-Stoelting, Albert Braeuning
Summary: In real life, organisms are exposed to complex mixtures of chemicals at low concentration levels, whereas research on toxicological effects is mostly focused on single compounds at comparably high doses. Mixture effects deviating from the assumption of additivity, especially synergistic effects, are of concern. This study demonstrates the enhanced triglyceride accumulation in human liver cells caused by a mixture of fatty chemicals at low concentrations, revealing potentially synergistic effects. Mathematical modeling and transcript pattern analysis further support the existence of more than additive behavior in mixture effects.
Article
Oncology
Anjin Wang, Qiying Xu, Rengaowa Sha, Tonghui Bao, Xiaoli Xi, Guilan Guo
Summary: The study revealed that miR-29a was downregulated in cervical cancer tissues and cells, and inhibited cell proliferation and induced cell cycle arrest by regulating the methylation level of the p16 gene.
Review
Food Science & Technology
Jie Zhang, Petr Pavek, Rajamanikkam Kamaraj, Li Ren, Tiehua Zhang
Summary: As a review, this paper summarizes the types and mechanisms of plant-derived pregnane X receptor (PXR) modulators and provides crystal structure information related to PXR binding. Furthermore, it summarizes the agonists, partial agonists, and antagonists of PXR from botanical sources. Further research is needed to screen more plant-derived PXR antagonists for antagonizing PXR function.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Robert S. Rogers, Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D'Ambrosio, Gregory Ruddy, Kaitlin Stackable, Megan Carney, Lauren Martin, Thomas Osterholt, Jeff L. Staudinger
Summary: Pregnane X receptor (PXR) is highly expressed in the enterohepatic system and regulates the expression of genes encoding key drug metabolizing enzymes and drug transporter proteins. Activation of PXR increases metabolism and clears drugs and xenobiotics from the body, mediating important drug interactions. PXR activation also transrepresses inflammatory- and nutrient-signaling pathways, connecting these pathways with drug biotransformation pathways. Research on post-translational modifications (PTMs) of PXR is still in its early stages.
Article
Biochemistry & Molecular Biology
Hironobu Yagishita, Hideaki Kagaya, Mitsuru Saito, Kazuyuki Numakura, Ryohei Yamamoto, Ryuichiro Sagehashi, Tomonori Habuchi, Shigeru Satoh, Masatomo Miura
Summary: The study evaluated the effects of NR1I2 and ABCB1 genetic polymorphisms on everolimus pharmacokinetics in Japanese renal transplant patients. The results showed significant correlations between different genotypes, gender, age, and liver function with the dose-adjusted AUC(0-12) of everolimus. Therefore, age and liver function should be considered when evaluating dose reductions for everolimus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Juan Pablo Rigalli, Dirk Theile, Julie Nilles, Johanna Weiss
Summary: PXR interacts with RXRα to regulate drug metabolism, immune function, and cancer pathogenesis; its activity is regulated by coactivator and corepressor proteins; studies indicate cell- and ligand-specific differences in PXR activation.
Article
Gastroenterology & Hepatology
Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota
Summary: The pregnane X receptor (PXR) plays an important role in regulating intestinal inflammation and fibrosis. Microbiota-derived indole-3-propionic acid (IPA) influences PXR signaling. Deletion of PXR exacerbates fibrosis, suggesting that microbiota metabolites may be a vital determinant in the progression of fibrotic complications in inflammatory bowel diseases (IBDs).
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yongdong Niu, Meishu Xu, Betty L. Slagle, Haihua Huang, Song Li, Grace L. Guo, Ganggang Shi, Wenxin Qin, Wen Xie
Article
Pharmacology & Pharmacy
You-Jin Choi, Dong Zhou, Anne Caroline S. Barbosa, Yongdong Niu, Xiudong Guan, Meishu Xu, Songrong Ren, Thomas D. Nolin, Youhua Liu, Wen Xie
MOLECULAR PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xiaobing Hong, Zelin Yu, Zhonglin Chen, Hongyan Jiang, Yongdong Niu, Zhanqin Huang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Gastroenterology & Hepatology
Jiong Yan, Hung-Chun Tung, Sihan Li, Yongdong Niu, Wojciech G. Garbacz, Peipei Lu, Yuhan Bi, Yanping Li, Jinhan He, Meishu Xu, Songrong Ren, Satdarshan P. Monga, Robert F. Schwabe, Da Yang, Wen Xie
Review
Pharmacology & Pharmacy
Yaqi Xing, Jiong Yan, Yongdong Niu
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Cell Biology
Li Zhang, Mengmeng Song, Fan Zhang, Hao Yuan, Wenjun Chang, Guanyu Yu, Yongdong Niu
Summary: The study identified that stromal NNMT expression is significantly increased in GC, predicting an unfavorable post-operative prognosis, with high expression significantly associated with tumor stage. However, patients with low stromal NNMT expression might respond better to adjuvant chemotherapy and have a more favorable prognosis.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Virology
Yongdong Niu, Liming Chen, Manpeng Wu, Weiyi Huang, Xuejun Wu, Danmei Huang, Yangmin Xie, Ganggang Shi
Summary: The study found that both full-length HBx and HBx C-terminal truncation coexist in HCC, and both can activate FXR signaling. Additionally, HBx-C30 has a weaker coactivating effect on FXR-KNG1 signaling compared to full-length HBx.
Article
Chemistry, Multidisciplinary
Dai-Fei Shen, He Cheng, Bo-Zhi Cai, Wen-Feng Cai, Bin Wang, Qing Zhu, Yue-Bin Wu, Man Liu, Run-Ji Chen, Fen-Fei Gao, Yan-Mei Zhang, Yong-Dong Niu, Gang-Gang Shi
Summary: N-n-Butyl haloperidol iodide (F-2) demonstrates significant anti-fibrotic activity in mouse liver fibrosis by inhibiting c-Jun expression to reduce TGFBR2 levels and decrease the responsiveness of hepatic stellate cells to TGF-β 1.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Xiaohua Huang, Bin Wang, Runji Chen, Shuping Zhong, Fenfei Gao, Yanmei Zhang, Yongdong Niu, Congzhu Li, Ganggang Shi
Summary: The study aimed to assess the mechanism of FXR in cervical cancer and found that FXR reduces cell viability, induces apoptosis, and promotes cell cycle arrest. FXR inhibits cervical cancer by upregulating SHP, MDM2, and p53.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haoran Li, Zihao Qi, Yongdong Niu, Yufei Yang, Mengjiao Li, Yangyang Pang, Mingming Liu, Xi Cheng, Midie Xu, Ziliang Wang
Summary: FBP1 expression is significantly decreased in ovarian cancer tissues and low expression predicts poor prognosis. Enhanced FBP1 expression suppresses cancer cell proliferation and invasion, increases sensitivity to chemotherapy.
Article
Plant Sciences
Hanif Khan, Zhengzhong Ni, Hai Feng, Yaqi Xing, Xuejun Wu, Danmei Huang, Ling Chen, Yongdong Niu, Ganggang Shi
Summary: This study evaluated the anti-tumor effect of curcumin in combination with F2 on hepatocellular carcinoma and found that the combination treatment significantly inhibited malignant proliferation and migration of HCC cells. The mechanism seemed to be associated with the downregulation of EZH2 and silencing of the Wnt/beta-catenin signaling pathway by interacting with H19, suggesting F2C may be a promising drug in the clinical treatment of HCC.
Article
Multidisciplinary Sciences
Zhengzhong Ni, Jun Lu, Weiyi Huang, Hanif Khan, Xuejun Wu, Danmei Huang, Ganggang Shi, Yongdong Niu, Haihua Huang
Summary: This study identified 12 key genes associated with HBx through RNA sequencing analysis of HepG2 cells overexpressing HBx, and validated their expression in HCC transcription profiles. Among these genes, the expression of ARG1 and TAT was correlated with a good prognosis in HCC patients.
Article
Gastroenterology & Hepatology
Liming Chen, Yongdong Niu, Jiating Sun, Hong Lin, Guoxi Liang, Min Xiao, Dongmei Shi, Jia Wang, Huachen Zhu, Yi Guan
Summary: NDV/HK84 showed excellent oncolytic activity against HCC with minimal impact on healthy cells, and its activity was found to be dependent on the activation of type I interferon signaling based on RNA sequencing analysis.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yongdong Niu, Shaohua Fan, Qin Luo, Liming Chen, Danmei Huang, Wenjun Chang, Wenxin Qin, Ganggang Shi
Summary: HBV infection increases hepatocellular sensitivity to carcinogenic xenobiotics and promotes hepatocellular carcinoma formation. The HBx-PXR-CYP3A4/GSTM1-KRAS-IL11:IL11RA signaling axis plays a crucial role in enhancing the toxicity of chemical carcinogens in HBV-associated hepatocarcinogenesis.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
