Review
Oncology
Chunxiu Peng, Zhijian Ye, Ying Ju, Xiuxin Huang, Chenjie Zhan, Ke Wei, Zhiyong Zhang
Summary: Hepatocellular carcinoma (HCC) caused by HBV, HCV infection, and other factors is a common malignancy worldwide. Current percutaneous and transcatheter treatments are not sufficient to improve the prognosis of HCC patients. Combination therapy with external interferon agents and other drugs has shown promising results in reducing recurrence rates and improving survival in HCC patients after surgery. This review focuses on the mechanism of action of type I interferons, emerging therapies, and potential therapeutic strategies for the treatment of HCC using IFNs.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Saranya Chidambaranathan Reghupaty, Sadia Kanwal, Rachel G. Mendoza, Eva Davis, Haiwen Li, Zhao Lai, Mikhail G. Dozmorov, Milton Omar Faison, Rafat Ali Siddiqui, Devanand Sarkar
Summary: Hepatocellular carcinoma (HCC) is a common primary liver cancer influenced by chronic liver inflammation and race/ethnicity. Analysis of RNA-sequencing data revealed the activation of an inflammatory pathway in HCC tumors of African-American/Black patients. Ginger extract (GE), known for its anti-inflammatory properties, showed potential efficacy in inhibiting HCC cell growth, particularly in cells from African-American/Black patients. These findings suggest that a holistic diet containing ginger may benefit African-American/Black HCC patients.
Article
Chemistry, Multidisciplinary
Tong Guo, Xiuli Liu, Zhikun Zhang, Yiqun Luo, Tong Li, Lan Li, Huixue Wang, Yong Huang, Jian He, Qiaoying Chen, Yongxiang Zhao, Lu Gan, Liping Zhong
Summary: The study on using matrix metalloproteinase to enhance oncolytic virus (NDV-MMP8) spread in tumors showed that in vitro and in vivo experiments, NDV-MMP8 can effectively degrade extracellular matrix, promote virus spread, and reduce tumor growth.
CHINESE CHEMICAL LETTERS
(2021)
Review
Oncology
Licheng Zhu, Yu Lei, Jia Huang, Yahang An, Yanqiao Ren, Lei Chen, Huangxuan Zhao, Chuansheng Zheng
Summary: Hepatocellular carcinoma (HCC) is a highly refractory cancer and the fourth leading cause of cancer-related mortality worldwide. Oncolytic viruses have been extensively researched as a new cancer therapeutic agent in the treatment of HCC. These viruses can increase targeting to HCC, kill tumor cells, inhibit HCC growth, and have shown promising results in clinical trials.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U. Jung, Huaping Liang, Xiaozhen Liang
Summary: Type I interferons (IFNs) are the first line of defense against invading pathogens. This study identified a previously unknown protein, PINLYP, that interacts with TBK1 to induce the production of type I IFN. Loss of PINLYP impaired the activation of IRF3 and the production of IFN induced by various viruses and Toll-like receptor ligands. Mice lacking PINLYP were more susceptible to lethal virus infection, highlighting the importance of PINLYP in the host defense against viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Timo Oosenbrug, Diana J. M. van den Wollenberg, Eline W. Duits, Rob C. Hoeben, Maaike E. Ressing
Summary: Oncolytic viruses selectively infect and kill tumor cells while triggering immune responses that boost anticancer immunity. Successful oncolytic virotherapy relies on tightly controlled levels of IFN-I, which requires understanding when and how tumor cells induce IFN-I in response to specific viruses.
HUMAN GENE THERAPY
(2021)
Article
Virology
Lili Deng, Xue Yang, Yuedi Ding, Jun Fan, Ying Peng, Dong Xu, Biao Huang, Zhigang Hu
Summary: In this study, a recombinant vaccinia virus, VG9-IL-24, was constructed, which selectively infected hepatocellular carcinoma cells and induced apoptosis, showing promising antitumor effects. Additionally, VG9-IL-24 blocked the cell cycle progression and suppressed tumor growth.
Article
Virology
Ching-Hsuan Liu, Chen-Jei Tai, Yu-Ting Kuo, Shen-Shong Chang, Liang-Tzung Lin
Summary: Hepatocellular carcinoma (HCC) is a challenging cancer to treat and requires more effective therapeutic strategies. In this study, the combination of oncolytic measles virus (MV) and natural triterpenoid compound ursolic acid (UA) showed synergistic cytotoxic effects on HCC cells, including those with hepatitis B virus (HBV) or hepatitis C virus (HCV) replication. The combination induced enhanced apoptosis, increased oxidative stress, and dysregulation of the mitochondria-dependent pathway. These findings highlight the potential of the MV and UA combination as a treatment strategy for HCC.
Review
Biology
Upasana Pathak, Ramprasad B. Pal, Nagesh Malik
Summary: The prospect of cancer treatment has changed significantly in the past forty years, leading to the exploration of novel and alternative cancer therapies. Oncolytic virotherapy is an evolving treatment modality that uses oncolytic viruses to selectively attack cancer cells and stimulate an anti-cancer immune response. Newcastle disease virus (NDV) is considered a safe option compared to other oncolytic viruses, and extensive research is focused on understanding its mechanisms and potential applications in cancer interception.
Article
Chemistry, Medicinal
Xinnan Zheng, Weizhe Xu, Qi Ying, Jiajun Ni, Xiaoyuan Jia, Yanrong Zhou, Ting Ye, Gongchu Li, Kan Chen
Summary: This study reveals that AVL lectin can increase levels of inflammatory cytokines in hepatocellular carcinoma cells through activating the AP-1 signaling pathway, offering new insights into cancer therapy.
Article
Immunology
Xin Zhao, Wenji Huang, Yanjie Shi, Jiahong Guo, Hehe Xiao, Ning Ji, Jianhua Feng, Huifeng Dang, Jun Zou
Summary: PLAAT1 plays important roles in tumor suppression, transglutaminase activation, and peroxisomal biogenesis. This study shows that PLAAT1 inhibits the production of type I interferon and promotes virus replication in zebrafish. Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to degrade them.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anastasia S. Nikitina, Anastasia V. Lipatova, Anton O. Goncharov, Anna A. Kliuchnikova, Mikhail A. Pyatnitskiy, Ksenia G. Kuznetsova, Azzam Hamad, Pavel O. Vorobyev, Olga N. Alekseeva, Marah Mahmoud, Yasmin Shakiba, Ksenia S. Anufrieva, Georgy P. Arapidi, Mark V. Ivanov, Irina A. Tarasova, Mikhail V. Gorshkov, Peter M. Chumakov, Sergei A. Moshkovskii
Summary: This study compared the response of different cancer cell lines to type I interferon treatment in oncolytic therapy using vesicular stomatitis virus (VSV). The study identified differential effects and molecular factors by integrating analysis of transcriptome, proteome, and RNA editome. The results showed that inflammatory proteins and overexpression of EGFR and HER2 genes were associated with resistance and sensitivity to VSV, respectively. Furthermore, the protein expression level of HER2 in tumor cells might serve as a predictive biomarker for resistance to oncolytic viral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Bolni Marius Nagalo, Yumei Zhou, Emilien J. Loeuillard, Chelsae Dumbauld, Oumar Barro, Alexander T. Baker, Mansi Arora, James M. Bogenberger, Natalie Meurice, Joachim Petit, Pedro Luiz Serrano Uson, Faaiq Asiam, Elizabeth Raupach, Musa Gabere, Alexei Basnakian, Camila C. Simoes, Martin J. Cannon, Steven R. Post, Kenneth Buetow, Jean Christopher Chamcheu, Michael T. Barrett, Dan G. Duda, Bertram Jacobs, Richard Vile, Michael A. Barry, Lewis R. Roberts, Sumera Llyas, Mitesh J. Borad
Summary: This study demonstrates that wild-type Morreton virus has potential therapeutic effects on cholangiocarcinoma and hepatocellular carcinoma in vitro models. It can induce immune responses and lead to tumor regression. These findings support further development and clinical translation of Morreton virus as an oncolytic virotherapy platform.
Article
Microbiology
Nele Zoellner, Noemi Coesfeld, Frederik Henry De Vos, Jennifer Denter, Haifeng C. Xu, Elena Zimmer, Birgit Knebel, Hadi Al-Hasani, Sofie Mossner, Philipp A. Lang, Doreen M. Floss, Juergen Scheller
Summary: Researchers found that synthetic type I interferon signaling mainly originates from IFNAR2, rather than IFNAR1, by reformatting the structure of IFNAR1 and IFNAR2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Tonia Zangari, Mila B. Ortigoza, Kristen L. Lokken-Toyli, Jeffrey N. Weiser
Summary: The study found that infection of infants with Streptococcus pneumoniae can trigger inflammatory pathways to facilitate transmission, similar to influenza virus. By activating the type I interferon response, colonization of S. pneumoniae in the upper respiratory tract increases shedding and transmission by stimulating a wide array of genes, including those involved in mucin biosynthesis. This mechanism of S. pneumoniae contagion shared with viral infection highlights the importance of the induction of IFN-I signaling in driving respiratory contagion.
Article
Computer Science, Interdisciplinary Applications
Bhaskar Nautiyal, Rishi Prakash, Vrince Vimal, Guoxi Liang, Huiling Chen
Summary: Different versions of the SSA employing various mutation schemes were proposed in this study to enhance the optimization process for complex problems. The Gaussian mutation proved to be particularly effective in boosting the algorithm's exploration and exploitation abilities.
ENGINEERING WITH COMPUTERS
(2022)
Article
Computer Science, Interdisciplinary Applications
Abdelazim G. Hussien, Ali Asghar Heidari, Xiaojia Ye, Guoxi Liang, Huiling Chen, Zhifang Pan
Summary: This study proposes an enhanced variant of the whale optimization algorithm (WOA) called VCSWOA, which combines components from other algorithms. The comprehensive testing and comparison with other algorithms demonstrate that VCSWOA outperforms its peers in terms of performance.
ENGINEERING WITH COMPUTERS
(2023)
Article
Computer Science, Interdisciplinary Applications
Hongliang Zhang, Tong Liu, Xiaojia Ye, Ali Asghar Heidari, Guoxi Liang, Huiling Chen, Zhifang Pan
Summary: This paper presents a chaotic SSA with differential evolution (CDESSA) to improve the convergence speed and accuracy of the salp swarm algorithm (SSA) in handling complex optimization problems. Experimental results demonstrate that CDESSA performs significantly better than the original SSA and other compared methods in solving real-parameter optimization and engineering optimization problems.
ENGINEERING WITH COMPUTERS
(2023)
Article
Chemistry, Multidisciplinary
Zhuang Wang, Guoxi Liang, Huiling Chen
Summary: This research presents an intelligent model based on an enhanced butterfly optimization algorithm and support vector machine for predicting college students' career decisions. Through simulation experiments and comparisons, the effectiveness and superiority of the proposed model are demonstrated.
APPLIED SCIENCES-BASEL
(2022)
Article
Computer Science, Information Systems
Hanli Bao, Guoxi Liang, Zhennao Cai, Huiling Chen
Summary: The butterfly optimization algorithm (BOA) is a proposed swarm intelligence optimization algorithm that simulates the foraging behavior of butterflies. However, it has limitations such as slow convergence speed and low solution accuracy. To address this, two strategies are introduced: random replacement and crisscross search. In this study, a novel optimizer called random replacement crisscross butterfly optimization algorithm (RCCBOA) is proposed. Comparative experiments are conducted to evaluate the performance of RCCBOA, and it is combined with SVM and FS to construct a standardized model for overseas Chinese associations.
Article
Energy & Fuels
Sudan Yu, Ali Asghar Heidari, Caitou He, Zhennao Cai, Maha M. Althobaiti, Romany F. Mansour, Guoxi Liang, Huiling Chen
Summary: This paper proposes a new method called LNMHGS for parameter extraction of static solar PV models. The LNMHGS method achieves a balance between exploitation and exploration by introducing the Laplacian strategy and Nelder-Mead simplex mechanism. It efficiently estimates the parameters of PV models with better performance compared to other algorithms.
Article
Energy & Fuels
Xuemeng Weng, Yun Liu, Ali Asghar Heidari, Zhennao Cai, Haiping Lin, Huiling Chen, Guoxi Liang, Abdulmajeed Alsufyani, Sami Bourouis
Summary: The determination of photovoltaic parameters is crucial for solar system operation and energy management. This study proposes a new optimization algorithm TLBOBSA to accurately simulate PV models, and its advantages in parameter extraction are verified through experiments.
ENERGY SCIENCE & ENGINEERING
(2023)
Article
Virology
Muhammad Qureshi, Brian M. Worthington, Yongmei Liu, William Y. -M Cheung, Shuo Su, Zuoyi Zheng, Lifeng Li, Tommy T. -Y Lam, Yi Guan, Huachen Zhu
Summary: We conducted a molecular epidemiological survey of astroviruses in dromedaries from Saudi Arabia and Bactrian camels from Inner Mongolia, China. Two novel Bactrian and eight dromedary camel astroviruses were characterized using a hybrid sequencing approach. The diversity of these viruses expands our knowledge of dromedary camel astroviruses, and highlights potential recombination events among the astroviruses of camelids and other host species.
Article
Energy & Fuels
Ruyi Dong, Long Ma, Huiling Chen, Ali Asghar Heidari, Guoxi Liang
Summary: Due to the growing concerns over environmental protection, the paper proposes a hybrid algorithm called HKSOPSO-CP, which combines kernel search optimization and particle swarm optimization with Cauchy perturbation, to achieve economic and environmentally responsible power dispatching. Experimental results with benchmark functions show that HKSOPSO-CP outperforms various popular algorithms. When applied to solve the IEEE standard economic emission dispatch problems, HKSOPSO-CP algorithm demonstrates a better trade-off between fuel costs and emissions compared to other algorithms reported in the literature.
FRONTIERS IN ENERGY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Hanbin Guo, Yibiao Xiao, Canlin Liao, Jiating Sun, Yanchun Xie, Yitong Zheng, Guanhua Fan
Summary: This study investigated the relationship between online information exchange and app usage frequency in the online blood glucose management population. It found a significant U-shaped relationship between the two variables. The app usage frequency changed the most when the information exchange score was between 3.0 and 4.2, indicating the need to focus on and enhance health-related behaviors and activities within this score range.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Saleem Ahmed, Tor-Morten Groenli, Abdullah Lakhan, Yi Chen, Guoxi Liang
Summary: Urinary disease is a complex healthcare issue and urine tests have proven valuable in identifying conditions such as kidney disease and urinary tract infections. However, existing methods for urinary tract infection detection face limitations in data privacy and training/testing time. Our proposed method tackles these limitations and achieves high accuracy with minimal delay by combining federated learning, reinforcement learning, and a combinatorial optimization approach.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biology
Helong Yu, Chunliu Liu, Lina Zhang, Chengwen Wu, Guoxi Liang, Jose Escorcia-Gutierrez, Osama A. Ghoneim
Summary: Treatise on Febrile Diseases is an important classic book in Chinese material medica. This paper proposes a knowledge distillation-based TinyBERT-CNN model for intent classification in Treatise on Febrile Diseases, achieving high accuracy, recall, and F1 values of 96.4%, 95.9%, and 96.2% respectively.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Abdelazim G. Hussien, Guoxi Liang, Huiling Chen, Haiping Lin
Summary: Many real-world complex optimization problems can easily get stuck in local optima and fail to find the optimal solution, so new techniques and methods are needed to address these challenges. Metaheuristic algorithms, such as the Sine Cosine Algorithm (SCA), have gained attention due to their efficiency and simplicity. However, SCA, like other metaheuristic algorithms, has slow convergence and may struggle in sub-optimal regions. This study proposes an enhanced version of SCA called RDSCA that utilizes random spare/replacement and double adaptive weight techniques, resulting in competitive results compared to other metaheuristic algorithms.
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2023)
Article
Immunology
Lunzhi Yuan, Huachen Zhu, Peiwen Chen, Ming Zhou, Jian Ma, Xuan Liu, Kun Wu, Rirong Chen, Qiwei Liu, Huan Yu, Lifeng Li, Jia Wang, Yali Zhang, Shengxiang Ge, Quan Yuan, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia
Summary: The new SARS-CoV-2 variant Omicron can evade current vaccines and neutralizing antibodies, causing more severe infection and lung damage in juvenile and aged hamsters compared to adult hamsters. Juvenile hamsters have a reduced interferon response, while aged hamsters show excessive proinflammatory cytokine expression, delayed viral clearance, and aggravated lung injury. Early treatment with inhaled IFN-alpha 2b can suppress Omicron infection and lung pathogenesis in both juvenile and adult hamsters.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
