Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy

ISCOMATRIX Adjuvant Induces Efficient Cross-Presentation of Tumor Antigen by Dendritic Cells via Rapid Cytosolic Antigen Delivery and Processing via Tripeptidyl Peptidase II

(2014) M. Schnurr et al.   JOURNAL OF IMMUNOLOGY

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

(2011) S. Gardam et al.   BLOOD

Melanoma vaccines: developments over the past 10 years

(2011) Oliver Klein et al.   Expert Review of Vaccines

Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets

(2011) Eugene Varfolomeev et al.   Future Oncology

Small-molecule protein kinase inhibitors and their effects on the immune system: implications for cancer treatment

(2011) Patrick A Ott et al.   Immunotherapy

ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells

(2011) P. Duewell et al.   JOURNAL OF IMMUNOLOGY

Immunomodulatory effects of anti-angiogenic drugs

(2011) A Heine et al.   LEUKEMIA

Processing and cross-presentation of individual HLA-A, -B, or -C epitopes from NY-ESO-1 or an HLA-A epitope for Melan-A differ according to the mode of antigen delivery

(2010) N. C. Robson et al.   BLOOD

IAP inhibitors enhance co-stimulation to promote tumor immunity

(2010) Michael Dougan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Nonredundant Role for Canonical NF- B in Human Myeloid Dendritic Cell Development and Function

(2010) L. van de Laar et al.   JOURNAL OF IMMUNOLOGY

Smac mimetics: implications for enhancement of targeted therapies in leukemia

(2010) E Weisberg et al.   LEUKEMIA

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mature dendritic cells use endocytic receptors to capture and present antigens

(2010) C. D. Platt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression

(2010) Linda Zane et al.   VIROLOGY

A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB

(2009) Yao Dai et al.   BMC CANCER

A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic Leukemia

(2009) S. Loeder et al.   CANCER RESEARCH

RelB/p50 regulates CCL19 production, but fails to promote human DC maturation

(2009) Chiara Gasparini et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor Agonists

(2009) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

(2008) M. Fakler et al.   BLOOD

cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand

(2008) A. Dupoux et al.   BLOOD

Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients

(2008) Ashley J. Knights et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

(2008) Sivakumar Vallabhapurapu et al.   NATURE IMMUNOLOGY

Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex

(2008) A. Matsuzawa et al.   SCIENCE