Article
Immunology
Emily S. Ford, Koshlan Mayer-Blackwell, Lichen Jing, Kerry J. Laing, Anton M. Sholukh, Russell St. Germain, Emily L. Bossard, Hong Xie, Thomas H. Pulliam, Saumya Jani, Stacy Selke, Carlissa J. Burrow, Christopher L. McClurkan, Anna Wald, Alexander L. Greninger, Michael R. Holbrook, Brett Eaton, Elizabeth Eudy, Michael Murphy, Elena Postnikova, Harlan S. Robins, Rebecca Elyanow, Rachel M. Gittelman, Matyas Ecsedi, Elise Wilcox, Aude G. Chapuis, Andrew Fiore-Gartland, David M. Koelle
Summary: Hybrid immunity, resulting from a combination of vaccination and previous infection, offers greater protection against SARS-CoV-2 than either vaccination or prior infection alone. This study investigated the dynamics of spike-reactive T cells in individuals with hybrid immunity, following either SARS-CoV-2 infection or mRNA vaccination. The findings show that vaccination leads to expansions of memory T cell clones, while also generating diverse new T cell clones. The study provides insights into T cell responses to vaccines and emerging pathogens.
Article
Multidisciplinary Sciences
Reza Naghavian, Wolfgang Faigle, Pietro Oldrati, Jian Wang, Nora C. Toussaint, Yuhan Qiu, Gioele Medici, Marcel Wacker, Lena K. Freudenmann, Pierre-Emmanuel Bonte, Michael Weller, Luca Regli, Sebastian Amigorena, Hans-Georg Rammensee, Juliane S. Walz, Silvio D. Brugger, Malte Mohme, Yingdong Zhao, Mireia Sospedra, Marian C. Neidert, Roland Martin
Summary: Microbial organisms play important roles in physiological processes in the human body and can affect the response to immune checkpoint inhibitors. This study investigates the role of microbial organisms in immune reactivity against glioblastoma. The findings suggest that bacterial pathogens and gut microbiota may be involved in specific immune recognition of tumor antigens, revealing potential for personalized tumor vaccination approaches.
Article
Microbiology
Kirsten Freitag, Sara Hamdan, Matthias J. Reddehase, Rafaela Holtappels
Summary: CD8(+) T-cell responses to pathogens mainly target infected cells presenting pathogen-encoded peptides, with only a few peptides qualifying as epitopes. IDEs are preferred in vaccine design and CD8(+) T-cell immunotherapy.
Article
Cell Biology
Neda Feizi, Chiara Focaccetti, Ilenia Pacella, Gloria Tucci, Alessandra Rossi, Massimo Costanza, Rosetta Pedotti, John Sidney, Alessandro Sette, Claudia La Rocca, Claudio Procaccini, Giuseppe Matarese, Vincenzo Barnaba, Silvia Piconese
Summary: The study demonstrates that immune responses to cryptic apoptosis-associated epitopes (AEs) may contribute to immunopathology in neuroinflammation, as shown in a mouse model of MS (EAE). The presence of AE-specific CD8(+) T cells, their physiological control, and their exacerbation of disease severity when immunized with AEs during EAE induction were observed, supporting the role of AE-specific autoimmunity in neuroinflammation.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Concetta Ragone, Carmen Manolio, Angela Mauriello, Beatrice Cavalluzzo, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte, Luigi Buonaguro
Summary: This study demonstrates for the first time a high degree of homology in linear sequence, structure, and conformation between microbiota and tumor-associated antigens, suggesting that the anti-microbiota T cell memory in cancer patients may play a role in controlling cancer growth. This finding may have implications for the development of a novel preventive anti-cancer vaccine strategy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Catherine J. Reynolds, Joseph M. Gibbons, Corinna Pade, Kai-Min Lin, Diana Munoz Sandoval, Franziska Pieper, David K. Butler, Siyi Liu, Ashley D. Otter, George Joy, Katia Menacho, Marianna Fontana, Angelique Smit, Beatrix Kele, Teresa Cutino-Moguel, Mala K. Maini, Mahdad Noursadeghi, Tim Brooks, Amanda Semper, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Aine McKnight, Daniel M. Altmann, Rosemary J. Boyton
Summary: The study found that the initial strain of SARS-CoV-2 infection's impact on downstream immunity to heterologous variants of concern (VOCs) is unknown. After three antigen exposures, neutralization potency against different VOCs changed, and serology poorly predicted neutralizing immunity. Heterologous combinations of spike encountered during infection and vaccination shape subsequent cross-protection against VOCs.
Review
Immunology
Areez Shafqat, Mohamed H. Omer, Omar Ahmad, Mahnoor Niaz, Humzah S. Abdulkader, Shameel Shafqat, Ali Hassan Mushtaq, Abdullah Shaik, Ahmed N. Elshaer, Junaid Kashir, Khaled Alkattan, Ahmed Yaqinuddin
Summary: The spike protein is utilized in currently approved COVID-19 vaccines, but SARS-CoV-2 variants with spike protein mutations can escape immune responses. Research on SARS-CoV-2 epitopes is important for vaccine design and may lead to pan-coronavirus vaccines. T-cell epitopes, which target various antigens, have potential strategies to control SARS-CoV-2 infection despite antibody escape by variants.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nicolas Huot, Cyril Planchais, Pierre Rosenbaum, Vanessa Contreras, Beatrice Jacquelin, Caroline Petitdemange, Marie Lazzerini, Emma Beaumont, Aurelio Orta-Resendiz, Felix A. Rey, R. Keith Reeves, Roger Le Grand, Hugo Mouquet, Michaela Mueller-Trutwin
Summary: The study reveals that interferon-gamma (IFN-gamma) regulates the persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in bronchoalveolar macrophages from cynomolgus macaques up to 18 months postinfection. There is an interplay between NK cells and macrophages, and the production of IFN-gamma plays a regulatory role in the persistence of SARS-CoV-2.
Article
Immunology
Paula Ruibal, Ian Derksen, Marjolein van Wolfswinkel, Linda Voogd, Kees L. M. C. Franken, Angela F. El Hebieshy, Thorbald van Hall, Tom A. W. Schoufour, Ruud H. Wijdeven, Tom H. M. Ottenhoff, Ferenc A. Scheeren, Simone A. Joosten
Summary: There is growing interest in HLA-E-restricted T-cell responses as a potential vaccination target. This study developed a method for efficient peptide thermal exchange on HLA-E monomers and multimers, allowing high-throughput production. The optimized conditions for detection and analysis of peptide-specific T cells revealed new insights into the interaction between HLA-E and NKG2A/CD94 receptors.
Article
Medicine, Research & Experimental
Spencer E. Brightman, Martin S. Naradikian, Rukman R. Thota, Angelica Becker, Leslie Montero, Milad Bahmanof, Ashmitaa Logandha Ramamoorthy Premlal, Jason A. Greenbaum, Bjoern Peters, Ezra E. W. Cohen, Aaron M. Miller, Stephen P. Schoenberger
Summary: CD4+ T cells recognize peptide antigens presented on MHC class II and play a critical role in antitumor immunity. However, the extent to which tumor-specific CD4+ T cells directly recognize solid cancers expressing MHC-II is unclear. In this study, we isolated and characterized T cell antigen receptors (TCRs) from naturally primed CD4+ T cells specific for HPV-16 E6 and the KRASG12V mutation, and found that the TCRs recognized antigen-loaded target cells expressing MHC-II or B cell antigen-presenting cells (APCs), but failed to recognize tumor cells expressing the source protein even after induction of surface MHC-II expression. These findings suggest that priming and recognition of oncoproteins are predominantly mediated by crosspresenting APCs rather than direct recognition of tumor cells induced to express MHC-II.
Article
Immunology
Faezzah Baharom, Ramiro A. Ramirez-Valdez, Kennedy K. S. Tobin, Hidehiro Yamane, Charles-Antoine Dutertre, Ahad Khalilnezhad, Glennys Reynoso, Vincent L. Coble, Geoffrey M. Lynn, Matthew P. Mule, Andrew J. Martins, John P. Finnigan, Xiao Meng Zhang, Jessica A. Hamerman, Nina Bhardwaj, John S. Tsang, Heather D. Hickman, Florent Ginhoux, Andrew S. Ishizuka, Robert A. Seder
Summary: The study demonstrates that using a self-assembling nanoparticle vaccine and adjuvant can expand stem-like CD8(+) T cells, optimize anti-tumor immunity, and enhance the strength and effectiveness of the anti-tumor response.
Article
Oncology
Karan Kohli, Lu Yao, Theodore Scott Nowicki, Shihong Zhang, Ralph Graeme Black, Brett A. Schroeder, Erik A. Farrar, Jianhong Cao, Heather Sloan, Dawn Stief, Lee D. Cranmer, Michael J. Wagner, Douglas S. Hawkins, Venu G. Pillarisetty, Antoni Ribas, Jean Campbell, Robert H. Pierce, Edward Y. Kim, Robin L. Jones, Stanley R. Riddell, Cassian Yee, Seth M. Pollack
Summary: The study demonstrated that ETC targeting NY-ESO-1 with single-agent cyclophosphamide conditioning was well tolerated in patients with SS and MRCL. IL-15 could induce proliferation and activity in persisting NY-ESO-1-specific T cells even in patients with disease progression following ACT. These results support further evaluation of incorporating IL-15 into ACT trials post-infusion or at the time of progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott Abrams, John M. L. Ebos, Jonathan F. Lovell
Summary: The study successfully predicted and screened MHC-I restricted neoepitopes in a murine renal adenocarcinoma model, converting them into immunogenic nanoparticles which induced antitumor responses. One candidate neoepitope, Nesprin-2 L4492R (Nes2LR), not only induced functional responses within 20-plex or 60-plex particles, but also prevented tumor growth.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Marcus Mendes, Jarjapu Mahita, Nina Blazeska, Jason Greenbaum, Brendan Ha, Kelly Wheeler, Jiyao Wang, Deborah Shackelford, Alessandro Sette, Bjoern Peters
Summary: The Immune Epitope Database (IEDB) is a database that catalogs T cell, B cell, and major histocompatibility complex ligand information in the context of infectious disease, allergy, autoimmunity, and transplantation. IEDB-3D is an important component of this database, which provides three-dimensional structural data on T cell receptors, antibodies, and pairwise residue interactions between immune receptors and antigens. With the release of IEDB-3D 2.0, a new 3D viewer experience and epitope mapping system have been implemented, allowing for better visualization of epitope data and highlighting immunogenic regions of antigens.
Review
Chemistry, Multidisciplinary
Jeffrey Y. W. Mak, Ligong Liu, David P. Fairlie
Summary: Researchers have made significant contributions in the field of microbial natural products and synthetic ligands over the past decade, particularly focusing on compounds related to riboflavin and uracils that modulate immune cells. Through collaboration, they discovered a naturally occurring compound synthesized by bacteria that activates MAIT cells, leading to its use in detecting and characterizing MAIT cells in tissues.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Oncology
Celine M. Murner, Frank Stenner-Liewen, Burkhardt Seifert, Nicolas J. Mueller, Adrian Schmidt, Christoph Renner, Urs Schanz, Alexander Knuth, Markus G. Manz, Michael Scharl, Bernhard Gerber, Panagiotis Samaras
LEUKEMIA & LYMPHOMA
(2019)
Review
Nanoscience & Nanotechnology
Mona O. Mohsen, Daniel E. Speiser, Alexander Knuth, Martin F. Bachmann
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2020)
Article
Immunology
Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel, Martin F. Bachmann
Article
Oncology
Renier Myburgh, Jonathan D. Kiefer, Norman F. Russkamp, Chiara F. Magnani, Nicolas Nunez, Alexander Simonis, Surema Pfister, C. Matthias Wilk, Donal McHugh, Juliane Friemel, Antonia M. Mueller, Burkhard Becher, Christian Muenz, Maries van den Broek, Dario Neri, Markus G. Manz
Article
Biochemistry & Molecular Biology
Nick van Dijk, Alberto Gil-Jimenez, Karina Silina, Kees Hendricksen, Laura A. Smit, Jeantine M. de Feijter, Maurits L. van Montfoort, Charlotte van Rooijen, Dennis Peters, Annegien Broeks, Henk G. van der Poel, Annemarie Bruining, Yoni Lubeck, Karolina Sikorska, Thierry N. Boellaard, Pia Kvistborg, Daniel J. Vis, Erik Hooijberg, Ton N. Schumacher, Maries van den Broek, Lodewyk F. A. Wessels, Christian U. Blank, Bas W. van Rhijn, Michiel S. van der Heijden
Article
Multidisciplinary Sciences
Paulino Tallon de Lara, Hector Castanon, Marijne Vermeer, Nicolas Nunez, Karina Silina, Bettina Sobottka, Joaquin Urdinez, Virginia Cecconi, Hideo Yagita, Farkhondeh Movahedian Attar, Stefanie Hiltbrunner, Isabelle Glarner, Holger Moch, Sonia Tugues, Burkhard Becher, Maries van den Broek
Summary: The study reveals that CD39(+)PD-1(+)CD8(+) T cells play a critical role in dormant metastasis of breast tumors and are associated with dormancy in the lungs.
NATURE COMMUNICATIONS
(2021)
Review
Urology & Nephrology
Bettina Sobottka, Anja Lorch, Karina Silina, Maries van den Broek, Holger Moch
Summary: Recent guidelines have highlighted immune checkpoint inhibition as a core treatment strategy in advanced clear cell RCC, but the unsatisfactory prognosis of many patients may be due to resistance mechanisms within the tumor immune microenvironment. The complexity of the RCC TIME and its potential interdependence with tumor intrinsic alterations has been newly recognized, suggesting the importance of further investigation in metastatic RCC.
CURRENT OPINION IN UROLOGY
(2021)
Article
Immunology
Iva Lelios, Sebastian A. Stifter, Virginia Cecconi, Ekaterina Petrova, Mirjam Lutz, Dilay Cansever, Sebastian G. Utz, Burkhard Becher, Maries van den Broek, Melanie Greter
Summary: The research found that monocytes play a critical role in promoting UV-induced cutaneous squamous cell carcinoma, while Langerhans cells and dermal macrophages have negligible contribution to tumor formation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Laura Ducimetiere, Giulia Lucchiari, Gioana Litscher, Marc Nater, Laura Heeb, Nicolas Gonzalo Nunez, Laura Wyss, Dominik Burri, Marijne Vermeer, Julia Gschwend, Andreas E. Moor, Burkhard Becher, Maries van den Broek, Sonia Tugues
Summary: This study found that innate lymphocyte subpopulations cNKs and trILC1s play nonredundant roles in controlling liver metastasis seeding and outgrowth, respectively, and may contribute to developing therapies involving hepatic innate cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Marcel Andre Schneider, Laura Heeb, Michal Mateusz Beffinger, Stanislav Pantelyushin, Michael Linecker, Lilian Roth, Kuno Lehmann, Udo Ungethum, Sebastian Kobold, Rolf Graf, Maries Van den Broek, Johannes Vom Berg, Anurag Gupta, Pierre-Alain Clavien
Summary: Peripheral serotonin has pleiotropic effects on coagulation, metabolism, tissue regeneration, and cancer growth, but its impact on the tumor microenvironment is understudied. Serotonin deficiency in mice leads to reduced tumor growth, increased CD8(+) T cell accumulation, and decreased PD-L1 expression, suggesting a role in immune response regulation. Serotonin regulates PD-L1 expression on tumor cells through serotonylation and affects tumor growth and immune response.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Fabio Pagliarulo, Phil F. Cheng, Laurin Brugger, Nick van Dijk, Michiel van den Heijden, Mitchell P. Levesque, Karina Silina, Maries van den Broek
Summary: Lymphoid neogenesis in muscle invasive bladder cancer (MIBC) leads to the formation of tertiary lymphoid structures (TLS) in the tumor microenvironment (TME), which have positive prognostic and predictive associations. This study found that high TLS density, when combined with tumor mutational burden, serves as a novel independent prognostic biomarker in MIBC. Tumors with high TLS density showed increased gene signatures and infiltration of activated lymphocytes, particularly B-cell and CD8(+) T-cell co-infiltration. The study also identified TLS maturation subtypes, although TLS composition appeared to be influenced by the TME rather than the maturation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nick van Dijk, Alberto Gil-Jimenez, Karina Silina, Maurits L. van Montfoort, Sarah Einerhand, Lars Jonkman, Charlotte S. Voskuilen, Dennis Peters, Joyce Sanders, Yoni Lubeck, Annegien Broeks, Erik Hooijberg, Daniel J. Vis, Maries van den Broek, Lodewyk F. A. Wessels, Bas W. G. van Rhijn, Michiel S. van der Heijden
Summary: Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC), but lack predictive power. Comprehensive overview of tumor immune contexture, including TLS, is needed to better understand immunotherapy response in UC. Our study analyzed immune cell subsets in various tumor compartments, showing a pronounced immune cell presence in UC invasive margins and identifying distinct cellular composition clusters in TLS.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Urology & Nephrology
Yuki Sato, Karina Silina, Maries van den Broek, Kiyoshi Hirahara, Motoko Yanagita
Summary: Tertiary lymphoid structures (TLSs) are ectopic lymphoid tissues that drive antigen-specific immune responses at sites of chronic inflammation. Their presence correlates with disease course, with favorable outcomes in cancer and infection, but more severe disease in autoimmune and chronic inflammatory diseases. However, the mechanisms underlying these associations are still unclear.
NATURE REVIEWS NEPHROLOGY
(2023)
Review
Oncology
Paulino Tallon de Lara, Hector Castanon, Michelle Sterpi, Maries van den Broek
Summary: This article reviews the role and mechanisms of CD8(+) T cells in metastatic cancers, including their functions in controlling metastatic lesions, metastatic dormancy, metastatic clonal evolution, and their clinical implications.
Meeting Abstract
Oncology
A. Curioni, C. Britschgi, S. Hiltbrunner, L. Bankel, P. Gulati, W. Weder, I. Opitz, O. Lauk, C. Caviezel, A. Knuth, C. Munz, C. Renner, R. A. Stahel, U. Petrausch
ANNALS OF ONCOLOGY
(2019)