Review
Biochemistry & Molecular Biology
Sofia Frigerio, Dalia A. Lartey, Geert R. D'Haens, Joep Grootjans
Summary: Patients with IBD have an increased risk of CRC, which develops in a background of chronic inflammation and pro-inflammatory immune cells. The role of the immunosuppressive microenvironment in these cancers is not well understood, but it has gained more attention in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ana Margarida Barbosa, Alexandra Gomes-Goncalves, Antonio G. Castro, Egidio Torrado
Summary: The interaction between the immune system, microbiota, and cancer is crucial for cancer development and treatment, helping to improve therapeutic response and identify new targets for immunotherapy.
Review
Biochemistry & Molecular Biology
Luana Tripodi, Chiara Villa, Davide Molinaro, Yvan Torrente, Andrea Farini
Summary: The interaction between the immune system and skeletal muscle plays a crucial role in inflammatory muscle diseases and dystrophic conditions, affecting muscle regeneration and pathogenesis.
Review
Immunology
Yu Zhen, Wentao Shu, Xintong Hou, Yinan Wang
Summary: This study focuses on the role of innate immune cells in visceral adipose tissue (VAT) in maintaining tissue homeostasis and responding to changes induced by obesity, leading to chronic inflammation and metabolic diseases. The review emphasizes the importance of understanding the quantitative and functional changes in immune cells in the context of obesity-induced metabolic dysfunction, highlighting the need to consider complex interactive networks among different cell populations in the development of biotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Arshi Khanam, Joel V. Chua, Shyam Kottilil
Summary: This review discusses the current knowledge of innate and adaptive immune cell transformations associated with immunopathogenesis and disease outcome in chronic hepatitis B patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Lena M. Ernst, Eudald Casals, Paola Italiani, Diana Boraschi, Victor Puntes
Summary: The immune system plays a crucial role in maintaining the body's functional integrity by recognizing and destroying foreign agents and abnormal cells. Nanoparticles can interact with the immune system in complex ways, potentially leading to different immune responses.
Article
Cell & Tissue Engineering
G. Crosio, A. H. Huang
Summary: This review summarizes the literature on various immune cell types that have been implicated in tendon healing or disease. In addition to macrophages, other immune cell types may also play a role in regulating the immune environment and directly interacting with tendon cells.
EUROPEAN CELLS & MATERIALS
(2022)
Review
Immunology
Ling Zhao, Chen Hou, Naihong Yan
Summary: Neuroinflammation is an important cause of retinitis pigmentosa progression, and inflammation modulation plays a crucial role in treatment. Therapies targeting inflammation have shown potential in attenuating photoreceptor degeneration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuhuai Xie, Yuanyuan Wei
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in regulating antimicrobial responses in the host innate immune system, impacting immune cell development and function, inflammatory processes, and antiviral mechanisms through interactions with DNA, RNA, or proteins. Dysregulation of lncRNA function is linked to various human non-infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nyemkuna Fortingo, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky, Wendy B. Bollag
Summary: Inflammation plays a complex role in corneal wound healing. While acute inflammation is necessary to prevent infection, chronic or excessive inflammation can delay healing and worsen outcomes. Reductions in severe or chronic inflammation lead to better corneal clarity, thickness, and healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kavita Rawat, Shannon M. Soucy, Fred W. Kolling, Kiara Manohar Diaz, William T. King, Anita Tewari, Claudia V. Jakubzick
Summary: Recent studies have revealed the critical role of natural antibodies (NAbs) in antitumor immune responses. However, the role of NAbs in cancer immunosurveillance has not been explored due to the lack of in vivo models. In this article, the authors propose a role for NAbs in alerting the immune system against precancerous neoantigen-expressing cells. Four reproducible neoantigen-expressing cell models are identified, allowing investigation of cancer immunosurveillance mediators. The presence of NAbs is essential for the elimination of transformed cells and immunity against neoantigens. Additionally, NAb-deficient mice show a greater tumor burden in chemically and virally induced tumor models. Restoration of NAb repertoire leads to the recognition and elimination of neoantigen-expressing cells and cancer.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Jonathan Pol, Juliette Paillet, Celeste Plantureux, Guido Kroemer
Summary: Chronic inflammation increases the risk of malignant transformation through proliferative responses. Autoimmune responses can both drive chronic inflammation and enhance cancer immunosurveillance. Recent study confirmed the negative associations between breast cancer and rheumatoid arthritis or systemic lupus erythematosus.
Article
Multidisciplinary Sciences
Boutheina Cherif, Hana Triki, Slim Charfi, Lobna Bouzidi, Wala Ben Kridis, Afef Khanfir, Kais Chaabane, Tahya Sellami-Boudawara, Ahmed Rebai
Summary: The study found that the expression of B7-H6 protein in breast tumors is closely related to Her-2 overexpression, while B7-H6+ immune cells are associated with Scarff-Bloom-Richardson grade, PD-L1 expression, and NK cell status. The analysis revealed that patients with low expression of B7-H6 in cancer cells have a better prognosis, whereas B7-H6+ immune cells are significantly associated with longer survival.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Christina Nedeva
Summary: Sepsis is a life-threatening medical condition caused by abnormal immune responses. It consists of two phases: immune activation and immunosuppression leading to immune cell death. Lack of specific treatments is mainly due to limited knowledge of the immuno-physiology associated with the disease.
Editorial Material
Oncology
Claudia Burrello, Karin E. de Visser
Summary: Macrophages are a focal point of cancer immunotherapy research due to their significant role in promoting tumor growth. A recent study found that targeting macrophages can influence the tumor microenvironment and lead to coordinated antitumorigenic immune responses in a lung carcinoma mouse model.
CANCER IMMUNOLOGY RESEARCH
(2022)
Review
Immunology
Daniela F. Quail, Borko Amulic, Monowar Aziz, Betsy J. Barnes, Evgeniy Eruslanov, Zvi G. Fridlender, Helen S. Goodridge, Zvi Granot, Andres Hidalgo, Anna Huttenlocher, Mariana J. Kaplan, Ilaria Malanchi, Taha Merghoub, Etienne Meylan, Vivek Mittal, Mikael J. Pittet, Andrea Rubio-Ponce, Irina A. Udalova, Timo K. van den Berg, Denisa D. Wagner, Ping Wang, Arturo Zychlinsky, Karin E. de Visser, Mikala Egeblad, Paul Kubes
Summary: This article discusses the functional states and heterogeneity of neutrophils in cancer and provides a consensus statement on the controversies and solutions in neutrophil research. Further research is needed to understand the role of neutrophils in cancer and explore potential novel opportunities for cancer treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Cell Biology
Kevin Kos, Muhammad A. Aslam, Rieneke van de Ven, Max D. Wellenstein, Wietske Pieters, Antoinette van Weverwijk, Danique E. M. Duits, Kim van Pul, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A. M. Raeven, Sergio A. Quezada, Rudi Beyaert, Heinz Jacobs, Tanja D. de Gruijl, Karin E. de Visser
Summary: Breast cancer causes systemic immunosuppression, which affects the organotropism of metastasis. Tumor-educated regulatory T cells (T-regs) accumulate in distant organs and undergo transcriptional rewiring in response to mammary tumorigenesis. T-regs control natural killer (NK) cell activation in lymph nodes, thereby promoting lymph node metastasis. The ratio of T-regs to NK cells is increased in sentinel lymph nodes of breast cancer patients compared to healthy controls.
Article
Oncology
Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A. M. Raeven, Martina Schmittnaegel, Carola H. Ries, Karin E. de Visser
Summary: This study reveals that tumor-associated macrophages (TAMs) contribute to the accumulation of regulatory T cells (T-regs) in breast tumors by promoting the conversion of CD4(+) T cells into T-regs. It is found that TAMs directly promote the conversion of CD4(+) T cells into T-regs through TGF-beta, and indirectly enhance the accumulation of T-regs by enhancing PD-1 expression on CD4(+) T cells.
Article
Oncology
Mathilde M. Almekinders, Tycho Bismeijer, Tapsi Kumar, Fei Yang, Bram Thijssen, Rianne van der Linden, Charlotte van Rooijen, Shiva Vonk, Baohua Sun, Edwin R. Parra Cuentas, Ignacio I. Wistuba, Savitri Krishnamurthy, Lindy L. Visser, Iris M. Seignette, Ingrid Hofland, Joyce Sanders, Annegien Broeks, Jason K. Love, Brian Menegaz, Lodewyk Wessels, Alastair M. Thompson, Karin E. de Visser, Erik Hooijberg, Esther Lips, Andrew Futreal, Jelle Wesseling
Summary: Through a study on a Dutch population-based cohort of 10,090 women with pure DCIS, it was found that IME features are not predictors of subsequent ilBC, but correlate with other factors (grade, ER, HER2 status, Ki-67) known to be associated with invasive recurrences.
BRITISH JOURNAL OF CANCER
(2022)
Editorial Material
Immunology
Julia M. Houthuijzen, Karin E. de Visser
Summary: Breast cancer cells exploit lung-specific immunosuppressive fibroblasts to facilitate metastasis.
Article
Cell Biology
Danique E. M. Duits, Camilla Salvagno, Elisabeth A. M. Raeven, Kim Vrijland, Marjolein C. Stip, Cheei-Sing Hau, Daphne Kaldenbach, Karin E. de Visser
Summary: Neutrophils play critical roles in infections, tissue repair, and cancer. Several methods, including neutralizing antibodies, CXCR2 inhibitors, and the ATTAC approach, have been used to investigate their in vivo functions. The newly generated hMRP8-ATTAC mouse model efficiently reduces neutrophil levels under homeostatic conditions.
Article
Multidisciplinary Sciences
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Summary: MYC plays a crucial role in suppressing anti-tumour immunity in triple-negative breast cancer by directly regulating the transcription of interferon signalling genes. MYC overexpression decreases lymphocyte infiltration in tumors and prevents the recruitment and activation of immune cells. These findings reveal the mechanisms by which MYC overexpression leads to poor immunogenicity in triple-negative breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Bruggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A. M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S. M. E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F. A. Wessels, Karin E. de Visser, Marleen Kok
Summary: Immune checkpoint blockade (ICB) has revolutionized cancer therapy by promoting effective immune responses through the activation of CD4(+) T cells and the recruitment of eosinophils. This study demonstrates the critical role of eosinophils in ICB response and provides proof-of-principle for enhancing ICB efficacy through eosinophil engagement. Mechanistically, ICB increases IL-5 production, stimulating elevated eosinophil production and systemic eosinophil expansion.
Article
Cell Biology
Chin-Hsien Tsai, Yu-Ming Chuang, Xiaoyun Li, Yi-Ru Yu, Sheue-Fen Tzeng, Shao Thing Teoh, Katherine E. Lindblad, Mario Di Matteo, Wan-Chen Cheng, Pei-Chun Hsueh, Kung-Chi Kao, Hana Imrichova, Likun Duan, Hector Gallart-Ayala, Pei-Wen Hsiao, Massimiliano Mazzone, Julijana Ivanesevic, Xiaojing Liu, Karin E. de Visser, Amaia Lujambio, Sophia Y. Lunt, Susan M. Kaech, Ping-Chih Ho
Summary: T cell-mediated immunosurveillance in early-stage tumorigenesis guides metabolic reprogramming in tumor cells through non-canonical interferon gamma (IFNg)-STAT3 signaling, leading to immune evasion and the formation of a suppressive tumor microenvironment.
Review
Oncology
Karin E. de Visser, Johanna A. Joyce
Summary: Cancers consist of tumor cells and various non-cancerous cells in an altered extracellular matrix, forming complex ecosystems. The tumor microenvironment (TME) includes different immune cell types, cancer-associated fibroblasts, endothelial cells, pericytes, and other tissue-resident cells, all of which play critical roles in cancer pathogenesis. The composition and function of the TME can vary depending on the organ, cancer cell features, tumor stage, and patient characteristics. Understanding the interplay between tumor cell-intrinsic, cell-extrinsic, and systemic factors is crucial for developing effective anti-cancer treatments.
Article
Oncology
Olga S. S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. I. Isaeva, Hannah Garner, Max D. D. Wellenstein, Noor Bakker, Danique E. M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A. M. Raeven, Kim Vrijland, Marleen Kok, Karin E. E. de Visser
Summary: The use of immune checkpoint blockade (ICB) therapy in neoadjuvant and perioperative settings is gaining attention due to its clinical successes in advanced cancer patients. However, the impact of neoadjuvant ICB therapy on systemic immune landscape and metastatic spread is still uncertain. Tumors promote the expansion of regulatory T cells (T-regs), which suppress the immune response and contribute to tumor progression and metastasis. This study demonstrates that neoadjuvant ICB therapy in breast cancer patients inadvertently promotes the proliferation and activation of T-regs, which can counteract the efficacy of ICB therapy. By depleting T-regs, the intratumoral immune landscape becomes favorable for ICB response and induces lasting alterations in systemic immunity, leading to extended metastasis-related survival driven by CD8+ T cells.
Article
Oncology
Leonie Voorwerk, Olga I. I. Isaeva, Hugo M. M. Horlings, Sara Balduzzi, Maksim Chelushkin, Noor A. M. Bakker, Elisa Champanhet, Hannah Garner, Karolina Sikorska, Claudette E. E. Loo, Inge Kemper, Ingrid A. M. Mandjes, Michiel de Maaker, Jasper J. L. van Geel, Jorianne Boers, Maaike de Boer, Roberto Salgado, Marloes G. J. van Dongen, Gabe S. S. Sonke, Karin E. E. de Visser, Ton N. N. Schumacher, Christian U. U. Blank, Lodewyk F. A. Wessels, Agnes Jager, Vivianne C. G. Tjan-Heijnen, Carolien P. Schroder, Sabine C. C. Linn, Marleen Kok
Summary: This study found that invasive lobular breast cancer is the second most common subtype of breast cancer, but there is a lack of specific clinical trials for this type. They identified an immune-related subset of lobular breast cancer and observed synergy between immune checkpoint blockade and platinum in mouse models. In the GELATO trial, treatment with carboplatin and atezolizumab showed promising antitumor activity, especially for triple-negative lobular breast cancer.
Article
Oncology
Hanne Lefrere, Kat Moore, Giuseppe Floris, Joyce Sanders, Iris M. Seignette, Tycho Bismeijer, Dennis Peters, Annegien Broeks, Erik Hooijberg, Kristel Van Calsteren, Patrick Neven, Ellen Warner, Fedro Alessandro Peccatori, Sibylle Loibl, Charlotte Maggen, Sileny N. Han, Katarzyna J. Jerzak, Daniela Annibali, Diether Lambrechts, Karin E. de Visser, Lodewyk Wessels, Liesbeth Lenaerts, Frederic Amant
Summary: Patients with postweaning postpartum breast cancer (PP-BCPW) have a poor prognosis compared with other types of breast cancer. This study found that PP-BCPW patients with low expression of immunoglobulin genes but high infiltration of plasma B cells have an increased risk of metastasis and death.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Antoinette van Weverwijk, Karin E. E. de Visser
Summary: Tumours exhibit a wide range of variations in the distribution, composition, and activation state of immune cells, which affect their progression and response to immunotherapy. Understanding the mechanisms that regulate the diversity and function of immune cells in the tumour microenvironment will lead to the development of more targeted immunomodulatory strategies for the benefit of cancer patients.
NATURE REVIEWS CANCER
(2023)
