A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs

Gliadin, through the Activation of Innate Immunity, Triggers lncRNA NEAT1 Expression in Celiac Disease Duodenal Mucosa

(2021) Elisa Gnodi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma

(2021) Ying Shen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells

(2021) Carmen Lanzillotti et al.   Frontiers in Cell and Developmental Biology

Macrophage lineages in heart valve development and disease

(2020) Andrew J Kim et al.   CARDIOVASCULAR RESEARCH

Modulators of MicroRNA Function in the Immune System

(2020) Yunhui Jia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast‑like synoviocytes by downregulating IL‑17

(2020) Cheng Liu et al.   Molecular Medicine Reports

U1 snRNP regulates chromatin retention of noncoding RNAs

(2020) Yafei Yin et al.   NATURE

Macrophage-Enriched lncRNA RAPIA

(2020) Changbin Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LncRNA SNHG5 regulates cell apoptosis and inflammation by miR-132/PTEN axis in COPD

(2020) Qin Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis

(2020) Jiacai Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

LncRNA RP11-86H7.1 promotes airway inflammation induced by TRAPM2.5 by acting as a ceRNA of miRNA-9-5p to regulate NFKB1 in HBECS

(2020) Jun Zhao et al.   Scientific Reports

IFNβ-induced exosomal linc-EPHA6-1 promotes cytotoxicity of NK cells by acting as a ceRNA for hsa-miR-4485-5p to up-regulate NKp46 expression

(2020) Shuang Li et al.   LIFE SCIENCES

LincRNA-Cox2 promotes pulmonary arterial hypertension by regulating the let-7a-mediated STAT3 signaling pathway

(2020) Gesheng Cheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

LncRNAMalat1inhibition of TDP43 cleavage suppresses IRF3-initiated antiviral innate immunity

(2020) Wei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

(2020) Viorel Simion et al.   Nature Communications

LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation

(2019) Zi-ming Ye et al.   Cell Death & Disease

Predictive models of subcellular localization of long RNAs

(2019) Binyamin Zuckerman et al.   RNA

LncRNA GAS5 enhanced the killing effect of NK cell on liver cancer through regulating miR-544/RUNX3

(2019) Peipei Fang et al.   Innate Immunity

The long noncoding RNA ROCKI regulates inflammatory gene expression

(2019) Qiong Zhang et al.   EMBO JOURNAL

Identification of lncRNA‐155 encoded by MIR155HG as a novel regulator of innate immunity against influenza A virus infection

(2019) Mohamed Maarouf et al.   CELLULAR MICROBIOLOGY

The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response

(2019) Hongyu Lin et al.   NATURE IMMUNOLOGY

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

(2019) Pengfei Zhang et al.   Nature Communications

Atlas of Subcellular RNA Localization Revealed by APEX-Seq

(2019) Furqan M. Fazal et al.   CELL

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA

(2019) Nadiya Khyzha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Long Non-coding RNA LncATV Promotes Virus Replication Through Restricting RIG-I–Mediated Innate Immunity

(2019) Jingjing Fan et al.   Frontiers in Immunology

The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation

(2019) Ding-wen Cao et al.   ACTA PHARMACOLOGICA SINICA

LncRNA MIR155HG regulates M1/M2 macrophage polarization in chronic obstructive pulmonary disease

(2019) Nannan Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Long non‐coding RNA MALAT1 sponges miR‐149 to promote inflammatory responses of LPS‐induced acute lung injury by targeting MyD88

(2019) Wei‐Jun Liang et al.   CELL BIOLOGY INTERNATIONAL

Live imaging of mRNA using RNA-stabilized fluorogenic proteins

(2019) Jiahui Wu et al.   NATURE METHODS

Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA

(2019) Henan Xu et al.   NATURE IMMUNOLOGY

Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON)

(2019) John Hung et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells

(2019) Li-Mei Wu et al.   ATHEROSCLEROSIS

LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE

(2019) Xiao Han et al.   Science Advances

Long noncoding RNA MALAT1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a miR-199b/IKKβ/NF-κB signaling pathway

(2018) Heng-Jun Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Roseburia intestinalis -derived flagellin is a negative regulator of intestinal inflammation

(2018) Yongsheng Quan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response

(2018) Minghong Jiang et al.   CELL

Knockdown of LncRNA MALAT1 contributes to the suppression of inflammatory responses by up-regulating miR-146a in LPS-induced acute lung injury

(2018) Lingling Dai et al.   CONNECTIVE TISSUE RESEARCH

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

(2018) Umeharu Ohto et al.   IMMUNITY

LncRNA MALAT1 regulates sepsis-induced cardiac inflammation and dysfunction via interaction with miR-125b and p38 MAPK/NFκB

(2018) Hu Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Control of Immune Cell Homeostasis and Function by lncRNAs

(2018) Walter K. Mowel et al.   TRENDS IN IMMUNOLOGY

Universal Alternative Splicing of Noncoding Exons

(2018) Ira W. Deveson et al.   Cell Systems

lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis

(2018) Chin-An Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LncRNA SRA deregulation contributes to the development of atherosclerosis by causing dysfunction of endothelial cells through repressing the expression of adipose triglyceride lipase

(2018) Shuguo Yang et al.   Molecular Medicine Reports

LncITPF Promotes Pulmonary Fibrosis by Targeting HnRNP L Depending on Its Host Gene ITGBL1

(2018) Xiaodong Song et al.   MOLECULAR THERAPY

Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells

(2018) Yoav Lubelsky et al.   NATURE

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

(2018) Luigi Ferrucci et al.   Nature Reviews Cardiology

The Long Noncoding RNA MALAT1 Induces Tolerogenic Dendritic Cells and Regulatory T Cells via miR155/Dendritic Cell-Specific Intercellular Adhesion Molecule-3 Grabbing Nonintegrin/IL10 Axis

(2018) Jian Wu et al.   Frontiers in Immunology

Long noncoding RNA ANRIL contributes to the development of ulcerative colitis by miR-323b-5p/TLR4/MyD88/NF-κB pathway

(2018) Cuixia Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

lncRNA GAS5 promotes M1 macrophage polarization via miR-455-5p/SOCS3 pathway in childhood pneumonia

(2018) Xiaowen Chi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LncRNA-MM2P identified as a Modulator of Macrophage M2 Polarization

(2018) Ji Cao et al.   Cancer Immunology Research

Long non-coding RNA: a versatile regulator of the nuclear factor-κB signalling circuit

(2017) Xiaohua Mao et al.   IMMUNOLOGY

Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization

(2017) Yibiao Ye et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs

(2017) Margarita Schlackow et al.   MOLECULAR CELL

Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1)

(2017) Hongjae Sunwoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation

(2017) Meng Du et al.   Nature Communications

Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

(2017) Pornchai Kaewsapsak et al.   eLife

CD56 in the Immune System: More Than a Marker for Cytotoxicity?

(2017) Heleen H. Van Acker et al.   Frontiers in Immunology

Long non-coding RNA Lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages

(2017) Carlos Zgheib et al.   PLoS One

A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation

(2016) Maninjay K. Atianand et al.   CELL

The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB

(2016) Gui Zhao et al.   FEBS LETTERS

LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling

(2016) Guoku Hu et al.   JOURNAL OF IMMUNOLOGY

Unlinking an lncRNA from Its Associated cis Element

(2016) Vikram R. Paralkar et al.   MOLECULAR CELL

Local regulation of gene expression by lncRNA promoters, transcription and splicing

(2016) Jesse M. Engreitz et al.   NATURE

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

(2016) Jonathan J. Kotzin et al.   NATURE

Long non-coding RNAs: spatial amplifiers that control nuclear structure and gene expression

(2016) Jesse M. Engreitz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A long noncoding RNA associated with susceptibility to celiac disease

(2016) A. Castellanos-Rubio et al.   SCIENCE

Long noncoding RNA: Novel links between gene expression and innate immunity

(2016) Susan Carpenter   VIRUS RESEARCH

A long noncoding RNA positively regulates CD56 in human natural killer cells

(2016) Ruya Zhang et al.   Oncotarget

Molecular mechanisms of long noncoding RNAs on gastric cancer

(2016) Tianwen Li et al.   Oncotarget

Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

(2016) Yiwen Fang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages

(2015) Ai-Ping Mao et al.   BMC GENOMICS

Canine mammary cancer cells direct macrophages toward an intermediate activation state between M1/M2

(2015) Breno C.B. Beirão et al.   BMC Veterinary Research

The PU.1-Regulated Long Noncoding RNA Lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA-199a-5p

(2015) Ming-Tai Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Long Noncoding RNAs Are Substantially Less Folded than Messenger RNAs

(2015) Jian-Rong Yang et al.   MOLECULAR BIOLOGY AND EVOLUTION

LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure

(2015) Anna Postepska-Igielska et al.   MOLECULAR CELL

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Mast cells in human and experimental cardiometabolic diseases

(2015) Guo-Ping Shi et al.   Nature Reviews Cardiology

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparison of splice sites reveals that long noncoding RNAs are evolutionarily well conserved

(2015) Anne Nitsche et al.   RNA

Discovery and annotation of long noncoding RNAs

(2015) John S Mattick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Principles of Long Noncoding RNA Evolution Derived from Direct Comparison of Transcriptomes in 17 Species

(2015) Hadas Hezroni et al.   Cell Reports

Canonical Poly(A) Polymerase Activity Promotes the Decay of a Wide Variety of Mammalian Nuclear RNAs

(2015) Stefan M. Bresson et al.   PLoS Genetics

Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells

(2014) Chengwu Zeng et al.   BMC CANCER

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals

(2014) Masahiro Uesaka et al.   BMC GENOMICS

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

NRAV, a Long Noncoding RNA, Modulates Antiviral Responses through Suppression of Interferon-Stimulated Gene Transcription

(2014) Jing Ouyang et al.   Cell Host & Microbe

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

(2014) Jian-Feng Xiang et al.   CELL RESEARCH

Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA

(2014) M. A. Reddy et al.   DIABETES

Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli

(2014) Katsutoshi Imamura et al.   MOLECULAR CELL

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

The evolution of lncRNA repertoires and expression patterns in tetrapods

(2014) Anamaria Necsulea et al.   NATURE

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

RNA and dynamic nuclear organization

(2014) J. Rinn et al.   SCIENCE

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

(2014) P. Wang et al.   SCIENCE

Functional interactions among microRNAs and long noncoding RNAs

(2014) Je-Hyun Yoon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus

(2014) J-Y Liu et al.   Cell Death & Disease

Mapping of Immune-Mediated Disease Genes

(2013) Isis Ricaño-Ponce et al.   Annual Review of Genomics and Human Genetics

Coregulation and modulation of NF B-related genes in celiac disease: uncovered aspects of gut mucosal inflammation

(2013) N. Fernandez-Jimenez et al.   HUMAN MOLECULAR GENETICS

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Natural resolution of inflammation

(2013) Marcelo O. Freire et al.   PERIODONTOLOGY 2000

The long noncoding RNA THRIL regulates TNF  expression through its interaction with hnRNPL

(2013) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long noncoding RNAs regulate adipogenesis

(2013) Lei Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

(2013) S. Carpenter et al.   SCIENCE

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression

(2013) Vinod Kumar et al.   PLoS Genetics

NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer

(2013) Yihui Fan et al.   Protein & Cell

A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

(2013) Nicole A Rapicavoli et al.   eLife

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Noncoding Transcription at Enhancers: General Principles and Functional Models

(2012) Gioacchino Natoli et al.   Annual Review of Genetics

Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation

(2012) Guoliang Li et al.   CELL

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

(2012) J. E. Wilusz et al.   GENES & DEVELOPMENT

Long noncoding RNAs in C. elegans

(2012) J.-W. Nam et al.   GENOME RESEARCH

Genome-wide analysis of long noncoding RNA stability

(2012) M. B. Clark et al.   GENOME RESEARCH

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Control of somatic tissue differentiation by the long non-coding RNA TINCR

(2012) Markus Kretz et al.   NATURE

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MEN  noncoding RNAs

(2012) J. A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory dendritic cells: there is more than just immune activation

(2012) Susanne V. Schmidt et al.   Frontiers in Immunology

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer

(2011) C Braconi et al.   ONCOGENE

MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop

(2011) R. Ahmad et al.   Science Signaling

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Emerging Roles for Natural MicroRNA Sponges

(2010) Margaret S. Ebert et al.   CURRENT BIOLOGY

Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors

(2010) Motonari Kondo   IMMUNOLOGICAL REVIEWS

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

What do natural antisense transcripts regulate?

(2010) Andreas Werner et al.   RNA Biology

RIGorous Detection: Exposing Virus Through RNA Sensing

(2010) J. Rehwinkel et al.   SCIENCE

A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster

(2009) X. Zhang et al.   BLOOD

CTCF: Master Weaver of the Genome

(2009) Jennifer E. Phillips et al.   CELL

Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

(2009) Xun Zhang et al.   ENDOCRINOLOGY

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Human natural killer cells

(2008) M. A. Caligiuri   BLOOD

Ripples from neighbouring transcription

(2008) Miki Ebisuya et al.   NATURE CELL BIOLOGY

Imaging individual mRNA molecules using multiple singly labeled probes

(2008) Arjun Raj et al.   NATURE METHODS