Topics in Mathematical Pharmacology

The rise of systems pharmacology in drug discovery and development

(2014) Neil Benson et al.   Future Medicinal Chemistry

Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies

(2014) Yanguang Cao et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

A mathematical analysis of rebound in a target-mediated drug disposition model: I.Without feedback

(2013) Philip J. Aston et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Cross-membrane signal transduction of receptor tyrosine kinases (RTKs): from systems biology to systems pharmacology

(2012) Neil Benson et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification

(2012) Lambertus A. Peletier et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Mathematical analysis of the pharmacokinetic–pharmacodynamic (PKPD) behaviour of monoclonal antibodies: Predicting in vivo potency

(2011) Philip J. Aston et al.   JOURNAL OF THEORETICAL BIOLOGY

Theoretical Considerations of Target-Mediated Drug Disposition Models: Simplifications and Approximations

(2011) Peiming Ma   PHARMACEUTICAL RESEARCH

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

(2011) Piet H. van der Graaf et al.   PHARMACEUTICAL RESEARCH

Dynamics of target-mediated drug disposition

(2009) Lambertus A. Peletier et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Numerical validation and properties of a rapid binding approximation of a target-mediated drug disposition pharmacokinetic model

(2009) Anshu Marathe et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Selection between Michaelis–Menten and target-mediated drug disposition pharmacokinetic models

(2009) Xiaoyu Yan et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Approximations of the target-mediated drug disposition model and identifiability of model parameters

(2008) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS