The rise of systems pharmacology in drug discovery and development

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

(2013) P A Milligan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

(2013) N. Benson et al.   Interface Focus

Relevance of systems pharmacology in drug discovery

(2012) Lourdes Cucurull-Sanchez et al.   DRUG DISCOVERY TODAY

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee

(2012) John P. Huggins et al.   PAIN

Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry

(2011) Johan Gabrielsson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Systems Biology and Pharmacology

(2010) J M Berg et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Optimising in vivo pharmacology studies—Practical PKPD considerations

(2010) Johan Gabrielsson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Translational pharmacokinetic-pharmacodynamic modelling; application to cardiovascular safety data for PF-00821385, a novel HIV agent

(2009) Grant Langdon et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic–pharmacodynamic reasoning in drug discovery and early development

(2009) Piet H Van Der Graaf et al.   Future Medicinal Chemistry

Quantitative Disease, Drug, and Trial Models

(2008) Jogarao V.S. Gobburu et al.   Annual Review of Pharmacology and Toxicology

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

(2008) M DANHOF et al.   TRENDS IN PHARMACOLOGICAL SCIENCES