Nonalcoholic fatty liver disease - current status and future directions

Epidemiological, clinical, and biochemical characteristics of Saudi patients with nonalcoholic fatty liver disease: a hospital-based study

(2017) Waleed Al-hamoudi et al.   ANNALS OF SAUDI MEDICINE

Temporal Trends of Nonalcoholic Fatty Liver Disease–Related Hepatocellular Carcinoma in the Veteran Affairs Population

(2015) Sahil Mittal et al.   Clinical Gastroenterology and Hepatology

Fibrosis Progression in Nonalcoholic Fatty Liver vs Nonalcoholic Steatohepatitis: A Systematic Review and Meta-analysis of Paired-Biopsy Studies

(2015) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Nonalcoholic fatty liver disease

(2015) Timothy Hardy et al.   CURRENT OPINION IN GASTROENTEROLOGY

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

(2015) Robert J. Wong et al.   GASTROENTEROLOGY

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2015) Sumio Watanabe et al.   HEPATOLOGY RESEARCH

PNPLA3polymorphisms (rs738409) and non-alcoholic fatty liver disease risk and related phenotypes: a meta-analysis

(2015) Long Zhang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Clinical trial watch: Reports from the AASLD Liver Meeting®, Boston, November 2014

(2015) María-Carlota Londoño et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Characterization of metabolically unhealthy normal-weight individuals: Risk factors and their associations with type 2 diabetes

(2015) Nathalie Eckel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Management and diagnosis of fatty liver disease

(2015) Amanda Tamar Schneier et al.   Expert Review of Gastroenterology & Hepatology

Evolving therapies for non-alcoholic steatohepatitis

(2014) Herbert Tilg et al.   Expert Opinion on Drug Discovery

No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial

(2014) Arun J. Sanyal et al.   GASTROENTEROLOGY

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

(2014) William Peverill et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: A meta-analysis of diagnostic accuracy

(2014) Ke-Qing Shi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Bariatric Surgery Improves Histological Features of Nonalcoholic Fatty Liver Disease and Liver Fibrosis

(2014) Andrew A. Taitano et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Non-invasive assessment of liver fibrosis with impulse elastography: Comparison of Supersonic Shear Imaging with ARFI and FibroScan®

(2014) Christophe Cassinotto et al.   JOURNAL OF HEPATOLOGY

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Gut microbiome and nonalcoholic fatty liver diseases

(2014) Lixin Zhu et al.   PEDIATRIC RESEARCH

Systematic review with meta-analysis: non-invasive assessment of non-alcoholic fatty liver disease - the role of transient elastography and plasma cytokeratin-18 fragments

(2013) R. Kwok et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; Should we care?

(2013) Ebenezer T. Oni et al.   ATHEROSCLEROSIS

Linking intestinal homeostasis and liver disease

(2013) Bernd Schnabl   CURRENT OPINION IN GASTROENTEROLOGY

Dual Peroxisome Proliferator-Activated Receptor  /  Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects

(2013) B. Cariou et al.   DIABETES CARE

The efficiency of acoustic radiation force impulse imaging for the staging of liver fibrosis: a meta-analysis

(2013) Julia Nierhoff et al.   EUROPEAN RADIOLOGY

Simple Noninvasive Systems Predict Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2013) Paul Angulo et al.   GASTROENTEROLOGY

Dietary fructose in nonalcoholic fatty liver disease

(2013) Miriam B. Vos et al.   HEPATOLOGY

Association between thePNPLA3(rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data

(2013) Eric Trépo et al.   HEPATOLOGY

Immune and inflammatory pathways in NASH

(2013) Michal Ganz et al.   Hepatology International

Stepwise Combination of Simple Noninvasive Fibrosis Scoring Systems Increases Diagnostic Accuracy in Nonalcoholic Fatty Liver Disease

(2013) Münevver Demir et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

FXR activation normalizes insulin sensitivity in visceral preadipocytes of a rabbit model of MetS

(2013) Elena Maneschi et al.   JOURNAL OF ENDOCRINOLOGY

From NAFLD in clinical practice to answers from guidelines

(2013) Fabio Nascimbeni et al.   JOURNAL OF HEPATOLOGY

A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver

(2013) Raluca Pais et al.   JOURNAL OF HEPATOLOGY

Limited value of plasma cytokeratin-18 as a biomarker for NASH and fibrosis in patients with non-alcoholic fatty liver disease

(2013) Kenneth Cusi et al.   JOURNAL OF HEPATOLOGY

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

The Gordian Knot of dysbiosis, obesity and NAFLD

(2013) Wajahat Z. Mehal   Nature Reviews Gastroenterology & Hepatology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

The genetics of NAFLD

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Pharmacological agents for NASH

(2013) Vlad Ratziu   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

NIKEI: A New Inexpensive and Non-Invasive Scoring System to Exclude Advanced Fibrosis in Patients with NAFLD

(2013) Münevver Demir et al.   PLoS One

Non-alcoholic steatohepatitis: a microbiota-driven disease

(2013) Alexander R. Moschen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Value of Acoustic Radiation Force Impulse Imaging Elastography for Non-invasive Evaluation of Patients with Nonalcoholic Fatty Liver Disease

(2013) Carmen Fierbinteanu Braticevici et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Anti-inflammatory and metabolic actions of FXR: Insights into molecular mechanisms

(2012) Danielle A.A. Hollman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Association Between Nonalcoholic Fatty Liver Disease and Risk for Hepatocellular Cancer, Based on Systematic Review

(2012) Donna L. White et al.   Clinical Gastroenterology and Hepatology

Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study

(2012) A. Neumann et al.   DIABETOLOGIA

Nonalcoholic Fatty Liver Disease/Steatohepatitis: Epidemiology, Pathogenesis, Clinical Presentation and Treatment

(2012) Sandra Milic et al.   DIGESTIVE DISEASES

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

(2012) Sudeep Tanwar et al.   HEPATOLOGY

Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States

(2012) Donghee Kim et al.   HEPATOLOGY

Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers

(2012) Jiayun Shen et al.   JOURNAL OF HEPATOLOGY

Non-invasive diagnosis of non-alcoholic fatty liver disease. A critical appraisal

(2012) Mariana V. Machado et al.   JOURNAL OF HEPATOLOGY

The Framingham risk score and heart disease in nonalcoholic fatty liver disease

(2012) Sombat Treeprasertsuk et al.   LIVER INTERNATIONAL

Diagnostic and therapeutic implications of the association between ferritin level and severity of nonalcoholic fatty liver disease

(2012) Luca Valenti   WORLD JOURNAL OF GASTROENTEROLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

(2011) Kohichiroh Yasui et al.   Clinical Gastroenterology and Hepatology

Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008

(2011) Zobair M. Younossi et al.   Clinical Gastroenterology and Hepatology

Acoustic radiation force impulse-imaging and transient elastography for non-invasive assessment of liver fibrosis and steatosis in NAFLD

(2011) Mireen Friedrich-Rust et al.   EUROPEAN JOURNAL OF RADIOLOGY

Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial

(2011) Claudia O. Zein et al.   HEPATOLOGY

Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients

(2011) Robert P. Myers et al.   HEPATOLOGY

Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease

(2011) Kris V. Kowdley et al.   HEPATOLOGY

A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis

(2011) Vlad Ratziu et al.   HEPATOLOGY

Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis

(2011) Diana Joka et al.   HEPATOLOGY

The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study

(2011) Neeraj Bhala et al.   HEPATOLOGY

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis

(2011) Ruben Hernaez et al.   HEPATOLOGY

Clinical significance of serum autoantibodies in patients with NAFLD: results from the nonalcoholic steatohepatitis clinical research network

(2011) Raj Vuppalanchi et al.   Hepatology International

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease

(2011) Mark L. Palmeri et al.   JOURNAL OF HEPATOLOGY

Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe

(2011) Robert P. Myers et al.   JOURNAL OF HEPATOLOGY

Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis

(2011) M. Friedrich-Rust et al.   JOURNAL OF VIRAL HEPATITIS

Human nutrition, the gut microbiome and the immune system

(2011) Andrew L. Kau et al.   NATURE

Association Between Metabolic Syndrome and Liver Histology Among Children With Nonalcoholic Fatty Liver Disease

(2010) Heather M Patton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Atorvastatin and Antioxidants for the Treatment of Nonalcoholic Fatty Liver Disease: The St Francis Heart Study Randomized Clinical Trial

(2010) Temitope Foster et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity

(2010) Giovanni Musso et al.   ANNALS OF MEDICINE

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Rosiglitazone Revisited

(2010) Steven E. Nissen et al.   ARCHIVES OF INTERNAL MEDICINE

Population-based risk factors and resource utilization for HCC: US perspective

(2010) A. Sanyal et al.   CURRENT MEDICAL RESEARCH AND OPINION

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

(2010) V. W.-S. Wong et al.   GUT

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

(2010) Giovanni Musso et al.   HEPATOLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

PNPLA3variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

(2010) Elizabeth K. Speliotes et al.   HEPATOLOGY

The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis

(2010) Mustafa S. Ascha et al.   HEPATOLOGY

A Meta-analysis of Transient Elastography for the Detection of Hepatic Fibrosis

(2010) Justin Stebbing et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

A position statement on NAFLD/NASH based on the EASL 2009 special conference

(2010) Vlad Ratziu et al.   JOURNAL OF HEPATOLOGY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Elastography for the diagnosis of severity of fibrosis in chronic liver disease: A meta-analysis of diagnostic accuracy

(2010) E.A. Tsochatzis et al.   JOURNAL OF HEPATOLOGY

Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus

(2010) Nathalie C. Leite et al.   LIVER INTERNATIONAL

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonalcoholic Fatty Liver Disease: US-based Acoustic Radiation Force Impulse Elastography

(2010) Masato Yoneda et al.   RADIOLOGY

Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study

(2009) Nevin Oruc et al.   BMC GASTROENTEROLOGY

Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

(2009) Amy G. Shah et al.   Clinical Gastroenterology and Hepatology

Epidemiology and Natural History of Non-Alcoholic Steatohepatitis

(2009) Curtis K. Argo et al.   Clinics in Liver Disease

Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease

(2009) Philippe Mathurin et al.   GASTROENTEROLOGY

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

(2009) Kittichai Promrat et al.   HEPATOLOGY

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

(2009) Robin Haring et al.   HEPATOLOGY

Decreased survival of subjects with elevated liver function tests during a 28-year follow-up

(2009) Cecilia Söderberg et al.   HEPATOLOGY

Thiazolidinediones for the Treatment in NASH

(2009) Curtis K. Argo et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis

(2009) Austin Nelson et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered

(2009) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

(2009) Nina F. Schwenzer et al.   JOURNAL OF HEPATOLOGY

Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

(2009) Astrid Spruss et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial

(2009) John Willy Haukeland et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

(2008) Anna Wieckowska et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Placebo in Nonalcoholic Steatohepatitis: Insight Into Natural History and Implications for Future Clinical Trials

(2008) Rohit Loomba et al.   Clinical Gastroenterology and Hepatology

Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver

(2008) Nila Rafiq et al.   Clinical Gastroenterology and Hepatology

Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease

(2008) S A Harrison et al.   GUT

Peroxisome proliferator-activated receptor-δ induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice

(2008) Xiaomei Qin et al.   HEPATOLOGY

Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

(2008) Silvia Sookoian et al.   JOURNAL OF HEPATOLOGY

Epidemiology of non-alcoholic fatty liver disease in China

(2008) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY