The endothelium: influencing vascular smooth muscle in many ways

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

(2016) Sokrates Stein et al.   Aging-US

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Effects of carbenoxolone on flow-mediated vasodilatation in healthy adults

(2011) Wei-Ren Lan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Mechanisms of Propofol-Induced Vascular Relaxation and Modulation by Perivascular Adipose Tissue and Endothelium

(2011) Saira I. Kassam et al.   ANESTHESIA AND ANALGESIA

HNO Signaling Mechanisms

(2011) Jon M. Fukuto et al.   ANTIOXIDANTS & REDOX SIGNALING

Playing with Cardiac “Redox Switches”: The “HNO Way” to Modulate Cardiac Function

(2011) Carlo G. Tocchetti et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitroxyl (HNO): A Novel Redox Signaling Molecule

(2011) Barbara K. Kemp-Harper   ANTIOXIDANTS & REDOX SIGNALING

Endothelial Nox4 NADPH Oxidase Enhances Vasodilatation and Reduces Blood Pressure In Vivo

(2011) Robin Ray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

No Superoxide—No Stress?

(2011) Ralf P. Brandes et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Calorie restriction and resveratrol in cardiovascular health and disease

(2011) Vernon W. Dolinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AGE-BSA down-regulates endothelial connexin43 gap junctions

(2011) Chi-Young Wang et al.   BMC CELL BIOLOGY

AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats

(2011) Qin Yang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms

(2011) Y Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vascular Disease Risk in Patients With Hypertriglyceridemia: Endothelial Progenitor Cells, Oxidative Stress, Accelerated Senescence, and Impaired Vascular Repair

(2011) Eric Thorin   CANADIAN JOURNAL OF CARDIOLOGY

Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance

(2011) Urszula Razny et al.   Cardiovascular Diabetology

Enhanced K+-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE−/− mice

(2011) Timea Beleznai et al.   CARDIOVASCULAR RESEARCH

Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice

(2011) Wai San Cheang et al.   CARDIOVASCULAR RESEARCH

Endothelium-Derived Hyperpolarizing Factor Determines Resting and Stimulated Forearm Vasodilator Tone in Health and in Disease

(2011) Muhiddin A. Ozkor et al.   CIRCULATION

Connexin 37 Limits Thrombus Propensity by Downregulating Platelet Reactivity

(2011) Anne Angelillo-Scherrer et al.   CIRCULATION

H 2 O 2 Is the Transferrable Factor Mediating Flow-Induced Dilation in Human Coronary Arterioles

(2011) Yanping Liu et al.   CIRCULATION RESEARCH

Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels

(2011) Asif K. Mustafa et al.   CIRCULATION RESEARCH

Cell Signaling of Angiotensin II on Vascular Tone: Novel Mechanisms

(2011) Aurelie Nguyen Dinh Cat et al.   CURRENT HYPERTENSION REPORTS

Oxidative stress and endothelial dysfunction in hypertension

(2011) Eberhard Schulz et al.   HYPERTENSION RESEARCH

Opening of Small and Intermediate Calcium-Activated Potassium Channels Induces Relaxation Mainly Mediated by Nitric-Oxide Release in Large Arteries and Endothelium-Derived Hyperpolarizing Factor in Small Arteries from Rat

(2011) E. Stankevicius et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NOX Isoforms and Reactive Oxygen Species in Vascular Health

(2011) R. M. Touyz et al.   MOLECULAR INTERVENTIONS

Longevity hits a roadblock

(2011) David B. Lombard et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

The discovery of endothelium-dependent contraction: The legacy of Paul M. Vanhoutte

(2011) Matthias Barton   PHARMACOLOGICAL RESEARCH

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction

(2010) Steven G. Denniss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries

(2010) Mohamed D. H. Hassona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Novel Role for HNO in Local and Spreading Vasodilatation in Rat Mesenteric Resistance Arteries

(2010) Kathryn H. Yuill et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitroxyl (HNO) as a Vasoprotective Signaling Molecule

(2010) Michelle L. Bullen et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol

(2010) Gnanapragasam Arunachalam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycemic memory associated epigenetic changes

(2010) Andrew L. Siebel et al.   BIOCHEMICAL PHARMACOLOGY

Compromised vascular endothelial cell SKCa activity: a fundamental aspect of hypertension?

(2010) Christopher J Garland   BRITISH JOURNAL OF PHARMACOLOGY

Impairment of endothelial SKCa channels and of downstream hyperpolarizing pathways in mesenteric arteries from spontaneously hypertensive rats

(2010) AH Weston et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regeneration of the Endothelium in Vascular Injury

(2010) Paul M. Vanhoutte   CARDIOVASCULAR DRUGS AND THERAPY

Nitric oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2

(2010) Saher Hamed et al.   CARDIOVASCULAR RESEARCH

Coordination of Vasomotor Responses by the Endothelium

(2010) Kim A. Dora   CIRCULATION JOURNAL

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

Epigenetics

(2010) Mark E. Cooper et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

(2010) Augusto C. Montezano et al.   CLINICAL SCIENCE

Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation

(2010) Azza B. El-Remessy et al.   Experimental Diabetes Research

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and endothelial dysfunction in cerebrovascular disease

(2010) Sophocles Chrissobolis   Frontiers in Bioscience-Landmark

Arterial Stiffness and Endothelial Function

(2010) Daniel A. Duprez   HYPERTENSION

Arterial Stiffness Is Regulated by Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor During Changes in Blood Flow in Humans

(2010) Jeremy Bellien et al.   HYPERTENSION

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5

(2010) Paul W Caton et al.   JOURNAL OF ENDOCRINOLOGY

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

(2010) N. Xia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endothelium-Dependent Vasodilation in Human Mesenteric Artery Is Primarily Mediated by Myoendothelial Gap Junctions Intermediate Conductance Calcium-Activated K+ Channel and Nitric Oxide

(2010) P. S. Chadha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS

(2010) Chris R. Triggle et al.   Journal of the American Society of Hypertension

Epigenetic phenomena linked to diabetic complications

(2010) Luciano Pirola et al.   Nature Reviews Endocrinology

Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses

(2010) Cor de Wit et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelial dysfunction in diabetes: multiple targets for treatment

(2010) Hong Ding et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice

(2010) Ralf Köhler et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endothelium-derived hyperpolarising factors and associated pathways: a synopsis

(2010) Gillian Edwards et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pathophysiological relevance of NO signaling in the cardiovascular system: Novel insight from mice lacking all NO synthases

(2010) Masato Tsutsui et al.   PHARMACOLOGY & THERAPEUTICS

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

SIRT6 protects against pathological damage caused by diet-induced obesity

(2009) Yariv Kanfi et al.   AGING CELL

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

(2009) Masayuki Orimo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reactive oxygen species as cardiovascular mediators: Lessons from endothelial-specific protein overexpression mouse models

(2009) Tatsiana Suvorava et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Endothelial Ca2+-activated K+ channels in normal and impaired EDHF-dilator responses - relevance to cardiovascular pathologies and drug discovery

(2009) Ivica Grgic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors

(2009) Michel Félétou et al.   BRITISH JOURNAL OF PHARMACOLOGY

A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries

(2009) Karen L Andrews et al.   BRITISH JOURNAL OF PHARMACOLOGY

A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo

(2009) F. Krotz et al.   CARDIOVASCULAR RESEARCH

Vascular endothelial ageing, heartbeat after heartbeat

(2009) E. Thorin et al.   CARDIOVASCULAR RESEARCH

Different pathways with distinct properties conduct dilations in the microcirculation in vivo

(2009) Cor de Wit   CARDIOVASCULAR RESEARCH

Genetic Deficit of SK3 and IK1 Channels Disrupts the Endothelium-Derived Hyperpolarizing Factor Vasodilator Pathway and Causes Hypertension

(2009) Sebastian Brähler et al.   CIRCULATION

Arterial internal elastic lamina holes: relationship to function?

(2009) Shaun L. Sandow et al.   JOURNAL OF ANATOMY

Role of Hydrogen Peroxide and the Impact of Glutathione Peroxidase-1 in Regulation of Cerebral Vascular Tone

(2009) Mary L Modrick et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rho Kinase Inhibitors Prevent Endothelium-Dependent Contractions in the Rat Aorta

(2009) C. K. Y. Chan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of EDHF in type 2 diabetes-induced endothelial dysfunction

(2008) Yoonjung Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NO Targets SIRT1

(2008) Michael Potente et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells

(2008) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hydrogen Peroxide Potentiates the EDHF Phenomenon by Promoting Endothelial Ca 2+ Mobilization

(2008) David H. Edwards et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelin: 20 years from discovery to therapyThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.

(2008) Matthias Barton et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries

(2008) Yasuo Kansui et al.   CELL CALCIUM

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

Spontaneous Myocardial Infarction in Mice Lacking All Nitric Oxide Synthase Isoforms

(2008) Sei Nakata et al.   CIRCULATION

Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor–Mediated Relaxation

(2008) J. Saliez et al.   CIRCULATION

Modulation of Endothelial Cell K Ca 3.1 Channels During Endothelium-Derived Hyperpolarizing Factor Signaling in Mesenteric Resistance Arteries

(2008) Kim A. Dora et al.   CIRCULATION RESEARCH

WHAT'S WHERE AND WHY AT A VASCULAR MYOENDOTHELIAL MICRODOMAIN SIGNALLING COMPLEX

(2008) Shaun L Sandow et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypertension Increases Contractile Responses to Hydrogen Peroxide in Resistance Arteries through Increased Thromboxane A2, Ca2+, and Superoxide Anion Levels

(2008) A. B. Garcia-Redondo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Endothelium-dependent contractions: when a good guy turns bad!

(2008) Paul M. Vanhoutte et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

(2008) J. Ledoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of methyl β-cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin-rich domains

(2007) M Absi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide

(2007) Y-J Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen Peroxide Inhibits Cytochrome P450 Epoxygenases

(2007) Brandon T. Larsen et al.   CIRCULATION RESEARCH

Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension

(2007) Eva H. C. Tang et al.   PHYSIOLOGICAL GENOMICS

Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery

(2005) Yu-Jing Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY