Article
Nutrition & Dietetics
S. A. Vardar, Z. B. Doganlar, O. Kaya, P. Tayfur, N. Sut, O. Doganlar
Summary: This study found that the inflammatory, apoptosis, and heat shock protein gene expression responses to high-intensity interval exercise in healthy male volunteers depend strongly on their level of regular physical activity. Novelty: The levels of blood IL-6 and HSP60 mRNA following high-intensity exercise may indicate metabolic stress, while increased blood HSP70 mRNA in physically active men may indicate an alternative pathway for apoptosis suppression.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Chemistry, Analytical
Henri Vaha-Ypya, Harri Sievanen, Pauliina Husu, Kari Tokola, Tommi Vasankari
Summary: The study proposed relative intensity thresholds based on individual fitness to evaluate the accumulation of physical activity at different intensity levels. Participants with lower CRF were more active with relative thresholds, while those with higher CRF were more active with absolute thresholds.
Article
Sport Sciences
Naoto Fujii, Tomomi Fujimoto, Cao Yinhang, Kohei Dobashi, Ryoko Matsutake, Tatsuro Amano, Koichi Watanabe, Takeshi Nishiyasu
Summary: The study found that moderate doses of caffeine exacerbate hyperthermia-induced hyperventilation and reductions in cerebral blood flow during exercise in hot conditions with severe hyperthermia.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Oncology
Sabine Kesting, Peter Weeber, Martin Schoenfelder, Anja Pfluger, Henning Wackerhage, Irene von Luettichau
Summary: This study aimed to evaluate the feasibility and safety of a single bout of high-intensity interval training (HIIT) in childhood cancer patients. The results suggest that HIIT is safe and feasible in a small number of childhood cancer patients without severe side effects, and it can increase exercise intensity and heart rate levels.
Article
Multidisciplinary Sciences
Shuhiba Mohammad, Kelly Ann Hutchinson, Danilo Fernandes da Silva, Jayonta Bhattacharjee, Kurt McInnis, Dylan Burger, Kristi B. Adamo
Summary: The study characterized the circulating small extracellular vesicles (EVs) profile of pregnant and non-pregnant women after moderate-intensity exercise, showing that pregnant women had higher levels of small EVs at baseline and a significant increase post-exercise compared to non-pregnant women. Further research is needed to explore the functional roles of exercise-induced small EVs in pregnancy.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Isabela Roque Marcal, Karla Fabiana Goessler, Roselien Buys, Juliano Casonatto, Emmanuel Gomes Ciolac, Veronique A. Cornelissen
Summary: Post-exercise hypotension (PEH) is an important tool for managing hypertension, with high-intensity interval exercise (HIIE) showing a greater reduction in blood pressure during daytime ambulatory monitoring compared to moderate-intensity continuous exercise (MICE). Further studies are needed to confirm HIIE's superiority as a safe intervention for lowering blood pressure, particularly in older individuals with hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Sport Sciences
Xiaolin Yang, Yanchun Li, Dapeng Bao, Tao Mei, Gerile Wuyun, Duoqi Zhou, Jing Nie, Xiaohui Xia, Xiaoxi Liu, Zihong He
Summary: This study aimed to analyze the interindividual differences in response to high-intensity interval training (HIIT) and predict the effect on maximal oxygen uptake. A genome-wide association study (GWAS) was conducted and genetic variants associated with the response were identified. The study found that there were individuals who did not respond to HIIT and discovered genetic loci associated with the response.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Sport Sciences
Filipe Manuel Clemente, Rodrigo Ramirez-Campillo, Fabio Yuzo Nakamura, Hugo Sarmento
Summary: The study demonstrates that high-intensity interval training (HIIT) has significant positive effects on aerobic fitness, repeated sprint ability, and vertical jump height for male soccer players. The type of HIIT does not seem to affect these outcomes significantly.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Physiology
Qing Li, Li Zhang, Zhengguo Zhang, Yuhan Wang, Chongwen Zuo, Shumin Bo
Summary: The study suggests that 20 minutes of high-intensity interval training is more effective than 30 minutes in improving serum levels of BDNF and VEGF-A as well as cognitive function in healthy young men.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Alicen A. Whitaker, Stacey E. Aaron, Carolyn S. Kaufman, Brady K. Kurtz, Stephen X. Bai, Eric D. Vidoni, Robert N. Montgomery, Sandra A. Billinger
Summary: This study is the first to investigate the cerebrovascular and hemodynamic response to low-volume high-intensity interval exercise (HIIT) with 1-minute intervals in young healthy adults. The middle cerebral artery blood velocity (MCAv) did not decrease below baseline during low-volume HIIT, but it decreased below baseline immediately after HIIT and returned to resting values 30 minutes after HIIT. There were also differences in MCAv between sexes.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Physiology
Kegang Zhao, Zhongyi Hu, Tao Wang, Lei Tian, Maoye Wang, Ruijiang Liu, Chongwen Zuo, Wang Jihua
Summary: In untrained young males, high-intensity interval training protocols with different work-to-rest ratios significantly increase brain-derived neurotrophic factor levels, independent of exercise duration. Blood lactate levels correlate positively with changes in brain-derived neurotrophic factor, while serum cortisol levels show no correlation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Roeland J. W. Middelbeek, Piryanka Motiani, Nina Brandt, Pasquale Nigro, Jia Zheng, Kirsi A. Virtanen, Kari K. Kalliokoski, Jarna C. Hannukainen, Laurie J. Goodyear
Summary: Short-term exercise training at markedly different intensities similarly improves cardiovascular fitness but results in intensity-specific changes in cytokine responses to exercise.
NUTRITION & DIABETES
(2021)
Article
Endocrinology & Metabolism
Gidon J. Bonhof, Alexander Strom, Maria Apostolopoulou, Yanislava Karusheva, Theresia Sarabhai, Dominik Pesta, Michael Roden, Dan Ziegler
Summary: The study showed that in individuals with type 2 diabetes, a 12-week supervised high-intensity interval training program led to improvements in resting heart rate, heart rate variability, and orthostatic blood pressure regulation, but had limited effects on somatic nerve function and structure.
Article
Geriatrics & Gerontology
Nicolas Vidal-Seguel, Camilo Cabrera, Luciano Ferrada, Macarena Artigas-Arias, Andrea Alegria-Molina, Sergio Sanhueza, Alejandra Flores, Nolberto Huard, Jorge Sapunar, Luis A. Salazar, Reuben McGregor, Estefania Nova-Lamperti, Gabriel Nasri Marzuca-Nassr
Summary: This study aimed to investigate the regulatory effect of high-intensity interval training (HIIT) on neutrophil extracellular trap formation (NETosis) in older individuals. The results showed that HIIT significantly reduced the induction of NETosis in older men. This suggests that HIIT is a feasible non-invasive training strategy for regulating the immune response in older individuals.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anil T. John, Moniruddin Chowdhury, Md. Rabiul Islam, Imtiyaz Ali Mir, Md Zobaer Hasan, Chao Yi Chong, Syeda Humayra, Yukihito Higashi
Summary: This study found that both high-intensity interval training (HIIT) and continuous moderate-intensity training (CMT) can reduce blood pressure in physically inactive pre-hypertensive young adults; however, HIIT yielded more beneficial results in terms of reducing systolic blood pressure, diastolic blood pressure, and mean arterial pressure.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Medicine, Research & Experimental
Antoine Deney, Vanessa Nader, Anthony Matta, Romain Itier, Pauline Fournier, Olivier Lairez, Nathalie Pizzinat, Didier Carrie, Frederic Boal, Michel Galinier, Oksana Kunduzova, Rania Azar, Jerome Roncalli
Summary: This study found that more than half of patients with heart failure had coronary artery disease, and older age and male sex were common risk factors for both HFpEF and HFrEF.
MEDICAL SCIENCE MONITOR
(2022)
Article
Endocrinology & Metabolism
Subodh Verma, Nitish K. Dhingra, Javed Butler, Stefan D. Anker, Joao Pedro Ferreira, Gerasimos Filippatos, James L. Januzzi, Carolyn S. P. Lam, Naveed Sattar, Barbara Peil, Matias Nordaby, Martina Brueckmann, Stuart J. Pocock, Faiez Zannad, Milton Packer
Summary: This study analyzed the efficacy and safety of empagliflozin in patients with heart failure with reduced ejection fraction in addition to background foundational treatments. The results showed that empagliflozin reduced the risk of cardiovascular death and heart failure hospitalization, as well as total heart failure hospital admissions, regardless of background therapy or medication doses. Empagliflozin was well tolerated across all subgroups of patients.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yohann Rautureau, Marianne Berlatie, Daniel Rivas, Kurunradeth Uy, Alexandre Blanchette, Geraldine Miquel, Marie-Eve Higgins, Melanie Mecteau, Audrey Nault, Louis Villeneuve, Veronique Lavoie, Gabriel Theberge-Julien, Genevieve Brand, Line Lapointe, Maxime Denis, Camille Rosa, Annik Fortier, Lucie Blondeau, Marie-Claude Guertin, Marie-Pierre Dube, Eric Thorin, Jonathan Ledoux, David Rhainds, Eric Rheaume, Jean-Claude Tardif
Summary: ADCY9 gene plays a role in determining atherosclerotic outcomes in patients and in mice it has been shown to potentiate endothelial function and inhibit atherogenesis. The inactivation of Adcy9 leads to increased cAMP accumulation in response to certain activators and enhances endothelial-dependent vasodilation. Additionally, ADCY9 can regulate endothelial permeability and actin cytoskeleton in response to thrombin, affecting the development of atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Correction
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang-Sheng Ma, Kenneth J. Rothman, Sabrina Marler, Venkatesh Kumar Gurusamy, Menno V. Huisman
Summary: The name of the GLORIA-AF investigator was mistakenly written as Athanasios Kollias instead of Anastasios Kollias in the Acknowledgements section of the article. The error has been corrected.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Agnieszka Kotalczyk, Christine Teutsch, Hans-Christoph Diener, Sergio J. Dubner, Jonathan L. Halperin, Chang-Sheng Ma, Kenneth J. Rothman, Sabrina Marler, Venkatesh Kumar Gurusamy, Menno Huisman
Summary: This study compared the safety and effectiveness of different non-vitamin K antagonists (NOACs) in newly diagnosed atrial fibrillation (AF) patients. The results showed that dabigatran had a lower risk of major bleeding compared to rivaroxaban, but similar risks of stroke, myocardial infarction (MI), and death. Patients treated with dabigatran had similar risks of stroke, major bleeding, MI, and death compared to apixaban. Rivaroxaban had an increased risk of major bleeding compared to apixaban, but similar risks of stroke, MI, and death.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Environmental Sciences
Florent Besnier, Beatrice Berube, Jacques Malo, Christine Gagnon, Catherine-Alexandra Gregoire, Martin Juneau, Francois Simard, Philippe L'Allier, Anil Nigam, Josep Iglesies-Grau, Thomas Vincent, Deborah Talamonti, Emma Gabrielle Dupuy, Hanieh Mohammadi, Mathieu Gayda, Louis Bherer
Summary: The COVID-Rehab study investigates the effectiveness of an eight-week cardiopulmonary rehabilitation program for long-term COVID-19 patients. The study examines multiple outcomes including cardiorespiratory fitness, quality of life, and cognition. The findings will provide important guidance for the rehabilitation of long-term COVID-19 patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Cell Biology
Anthony Matta, Vanessa Nader, Marine Lebrin, Fabian Gross, Anne-Catherine Prats, Daniel Cussac, Michel Galinier, Jerome Roncalli
Summary: Transplantation of mesenchymal stem cells (MSCs) has shown good clinical outcomes in cardiovascular diseases such as heart failure, cardiomyopathy, and ischemic heart disease. This is attributed to reduced ventricular remodeling, myocardial fibrosis, scar size, and improved endothelial dysfunction. MSCs also exhibit regenerative, pro-angiogenic, anti-apoptotic, and anti-inflammatory effects. This review focuses on different preconditioning methods and novel approaches to optimize the efficacy of MSC therapy.
Article
Cardiac & Cardiovascular Systems
Anthony Matta, Vanessa Nader, Ronan Canitrot, Clement Delmas, Frederic Bouisset, Thibault Lhermusier, Stephanie Blanco, Francisco Campelo-Parada, Meyer Elbaz, Didier Carrie, Michel Galinier, Jerome Roncalli
Summary: This study aims to investigate the relationship between myocardial bridging (MB) and myocardial infarction with non-obstructive coronary arteries (MINOCA). The results showed that MB is a risk factor for MINOCA, with MINOCA mainly presenting as non-ST-segment elevation myocardial infarction. Further investigation for MB in MINOCA cases, especially in non-ST-segment elevation myocardial infarction patients, seems necessary.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Laetitia Pourtau, Maxime Beneyto, Jean Porterie, Jerome Roncalli, Montse Massot, Caroline Biendel, Pauline Fournier, Romain Itier, Michel Galinier, Olivier Lairez, Clement Delmas
Summary: This study aimed to investigate the prevalence, management, and outcomes of haemorrhagic adverse events in patients receiving left ventricular assist devices (LVADs). The study found that bleeding events were frequent and associated with increased mortality, with gastrointestinal bleeding being the most common and intracranial haemorrhage being the most associated with mortality.
Article
Cardiac & Cardiovascular Systems
Atul Pathak, Pierre Levy, Francois Roubille, Gilles Chatellier, Gregoire Mercier, Sarah Alami, Guila Lancman, Helene Pasche, Corinne Laurelli, Cecile Delval, Juan Fernando Ramirez-Gil, Michel Galinier
Summary: This study compared the healthcare resource consumption costs for chronic heart failure patients under telemonitoring and standard of care, with a slight cost reduction in the telemonitoring group over 18 months, primarily due to a decrease in nurse fees. Patients with severe heart failure showed a non-significant reduction in costs under telemonitoring, particularly in hospitalization and nursing fees.
Article
Cardiac & Cardiovascular Systems
Michel Galinier, Romain Itier, Anthony Matta, Montse Massot, Pauline Fournier, Ghislaine Galtier, Sandrine Ayot, Vanessa Nader, Max Rene, Laurent Lecourt, Jerome Roncalli
Summary: The study assessed the effects of interventional specialized telemonitoring (ITM) compared to standard telemonitoring (STM) and standard of care (SC) on preventing all causes of death, cardiovascular mortality, and unplanned hospitalization in heart failure (HF) patients. The results showed that the ITM group had lower rates of unplanned hospitalization and all causes of death compared to the SC and STM groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mathieu R. Brodeur, David Rhainds, Daniel Charpentier, Marie Boule, Teodora Mihalache-Avram, Melanie Mecteau, Genevieve Brand, Valerie Pedneault-Gagnon, Annik Fortier, Eric J. Niesor, Eric Rheaume, Cyrille Maugeais, Jean-Claude Tardif
Summary: The effects of CETP inhibitors on HDL particle composition were studied in rabbits and humans. The study found that these inhibitors increased the concentration of large apo E-containing HDL particles, which can interact with hepatic LDL receptors.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Reza Fadaei, Samaneh Mohassel Azadi, Eric Rheaume, Habibolah Khazaie
Summary: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD), and HDL cholesterol efflux capacity (CEC) may be impaired in OSA patients, potentially contributing to the risk of CVD.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Materials Science, Multidisciplinary
Yu-Chen Wang, Gabriel Theberge-Julien, Jean-Claude Tardif, Eric Rheaume, Frederic Lesage, Ashok Kakkar
Summary: We report a versatile methodology to covalently link hollow gold nanoshells (HAuNS) through the modular design of multi-tasking ligands and bio-adaptable chemistry. Ligand composition includes polyethylene glycol (PEG) chains, protected thiol-terminated tetraethylene glycol, and a reactive functional group. HAuNS are functionalized through in situ deprotection/thiol-Au binding. The ligand-functionalized HAuNS with surface exposed COOH or OH entities are used to construct linked-HAuNS through short chemical or longer bio-spacers, regulating inter-particle distance and interference of HAuNS surface plasmon resonance. The synthetic tools and facile chemistry described here provide opportunities in designing linked metal nanoparticles for broad applications in biology.
MATERIALS ADVANCES
(2022)
