Article
Medicine, General & Internal
Zubeyde Ercan, Gulnihal Deniz, Songul Baglan Yentur, Funda Bulut Arikan, Ahmet Karatas, Gokhan Alkan, Suleyman Serdar Koca
Summary: This study examined the effects of acute aerobic exercise on cytokines, irisin, klotho, and VEGF levels in patients with rheumatoid arthritis (RA). The results showed that acute aerobic exercise had an acute anti-inflammatory effect in RA patients, suggesting its potential as a beneficial addition to RA rehabilitation programs.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Physiology
Gabriella F. Bellissimo, Jeremy Ducharme, Zachary Mang, Desmond Millender, Jessica Smith, Matthew J. Stork, Johnathan P. Little, Michael R. Deyhle, Ann L. Gibson, Flavio de Castro Magalhaes, Fabiano Amorim
Summary: This study compared the acute physiological, perceptual, and enjoyment responses between bodyweight high-intensity interval exercise (BW-HIIE) and treadmill running high-intensity interval exercise (RUN-HIIE). The results showed that BW-HIIE elicited higher oxygen consumption, blood lactate, heart rate, and rating of perceived exertion compared to RUN-HIIE, while the physical activity enjoyment was similar between the two exercises.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Andrew M. Alexander, Shane M. Hammer, Kaylin D. Didier, Lillie M. Huckaby, Thomas J. Barstow
Summary: Recovery following extreme-intensity exercise is faster, with better recovery of MVC and Q(pot), compared to severe-intensity exercise. Gender has an impact on MVC and Q(pot), and future studies should further investigate this.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Food Science & Technology
Chia-Chien Hsieh, Yen-Fang Wang, Pin-Yu Lin, Shih-Han Peng, Mei-Jia Chou
Summary: The study revealed that lunasin can reduce inflammation levels in obese mice, decrease macrophage infiltration in adipose tissue, and regulate spleen size and cell numbers. Additionally, lunasin promotes the production of interferon gamma and interleukin-2 in splenocytes, thus modulating immune responses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Endocrinology & Metabolism
Marko T. Korhonen, Urho M. Kujala, Jyrki Kettunen, Olga V. Korhonen, Jaakko Kaprio, Seppo Sarna, Timo Tormakangas
Summary: Maintenance of vigorous exercise habits from young to old age is considered protective against hip fractures. This study found that continuing high-intensity exercise in old age is associated with a lower hazard rate of hip fractures, although this protective effect diminishes with age.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Physiology
Eisuke Ochi, Alice Barrington, Michelle Wehling-Henricks, Marcus Avila, Makoto Kuro-o, James G. Tidball
Summary: Research shows that the hormone Klotho inhibits the response of muscles to mechanical loading and exercise, preventing muscle cell differentiation and inhibiting the activation of the canonical Wnt pathway.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Macsue Jacques, Shanie Landen, Javier Alvarez Romero, Danielle Hiam, Ralf B. Schittenhelm, Iresha Hanchapola, Anup D. Shah, Sarah Voisin, Nir Eynon
Summary: Exercise has significant effects on both the epigenome and proteome in human muscle. A 12-week high-intensity interval training intervention was conducted on 16 healthy moderately trained males, and muscle biopsies were collected at baseline and after 4, 8, and 12 weeks. The study found significant changes in proteins and DNA methylation levels, with some proteins consistently changed across individuals and the discovery of two novel exercise-related proteins. These findings contribute to a better understanding of the impact of exercise on the human body.
Article
Chemistry, Multidisciplinary
Hae Sung Lee, Hyun Ju Oh, Kihae Ra, Jong-Hee Kim
Summary: This study investigated the effects of treadmill exercise on hematological and serum biochemical parameters, as well as the expression of immune-related cytokine genes in leukocytes. The results showed that short-term moderate-intensity endurance exercise decreased white blood cell count, aspartate aminotransferase, serum alkaline phosphatase, and glucose levels, while significantly decreasing the mRNA expression of TNF-alpha, IFN-gamma, IL-1 beta, and IL-4 in leukocytes.
APPLIED SCIENCES-BASEL
(2022)
Article
Pharmacology & Pharmacy
Isabela Roque Marcal, Vanessa Teixeira Do Amaral, Bianca Fernandes, Raphael Martins de Abreu, Cristian Alvarez, Guilherme Veiga Guimaraes, Veronique A. Cornelissen, Emmanuel Gomes Ciolac
Summary: This study aimed to assess the effects of high-intensity interval exercise and moderate-intensity continuous exercise on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension. The results showed that high-intensity interval exercise was more effective in improving parasympathetic modulation compared to moderate-intensity continuous exercise and control.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Physiology
Alexandre F. F. Machado, Paulo Vinicios Camuzi Zovico, Alexandre L. L. Evangelista, Roberta L. L. Rica, Joao Marcelo de Q. Miranda, Cristine Lima Alberton, Valentina Bullo, Stefano Gobbo, Marco Bergamin, Julien S. S. Baker, Danilo S. S. Bocalini
Summary: The study aimed to evaluate the effects of different exercise orders on training load indicators during HIIT sessions using body weight. The findings showed that exercise order did not significantly affect heart rate, perceived exertion, and lactate concentrations. However, there were significant differences in the number of movements and perceived recovery between different exercise orders.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Mousa Khalafi, Shima Mojtahedi, Alireza Ostovar, Sara K. Rosenkranz, Mallikarjuna Korivi
Summary: This meta-analysis investigated the effects of high-intensity interval exercise (HIIE) compared to moderate-intensity exercise (MIE) and a control condition (CON) on postprandial glucose (PPG) and insulin (PPI) responses. The results showed that HIIE reduced PPG and PPI compared to the control condition. Subgroup analyses revealed significant reductions in PPG and PPI for both children and adults, as well as for healthy participants and those with metabolic disorders, with larger effects observed in individuals with metabolic disorders. There were no significant differences between HIIE and MIE for PPG or PPI, but when studies matched for total work performed, HIIE was more effective for decreasing PPG. HIIE is effective for reducing PPG and PPI in both children and adults, particularly in those with metabolic disorders.
Article
Multidisciplinary Sciences
Blanca Marin Bosch, Aurelien Bringard, Maria G. Logrieco, Estelle Lauer, Nathalie Imobersteg, Aurelien Thomas, Guido Ferretti, Sophie Schwartz, Kinga Igloi
Summary: The study reveals that moderate intensity exercise enhances hippocampal memory performance and increases levels of endocannabinoids and BDNF, suggesting a synergistic modulation of underlying neural plasticity mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Morgane Pengam, Christelle Goanvec, Christine Moisan, Bernard Simon, Gaelle Albacete, Annie Feray, Anthony Guernec, Aline Amerand
Summary: This study aimed to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on metabolic processes in two different muscle types. The results showed that both training protocols led to specific muscular responses, with the genes involved being more significantly upregulated in the slow-twitch (soleus) muscle compared to the fast-twitch (extensor digitorum longus) muscle. HIIT showed better endurance performance and oxidative capacities in both muscles.
Article
Sport Sciences
Fatma Rhibi, Hassane Zouhal, Fabio Santos Lira, Nejmeddine Ouerghi, Jacques Prioux, Sophia Besbes, Jed M. Tijani, Anthony C. Hackney, Abderraouf Ben Abderrahman
Summary: This study examined the effects of high-intensity intermittent training (HIIT) programs with varying intensities on metabolic, hormonal, and inflammatory markers in young men. The results showed that training at 110% of maximal aerobic velocity (MAV) was more effective in improving markers such as glucose, cortisol, and IL-6 at rest, at the end of exercise, and during recovery compared to training at 100% MAV.
Article
Hospitality, Leisure, Sport & Tourism
Justin P. Guilkey, Meral Culver, Matthew Wolfe, Kelly E. Johnson, Jakob D. Lauver, Jenna Thompson
Summary: This study examined the acute physiological responses of healthy adults to different exercise protocols. The results showed that variable-intensity intermittent exercise (VIIE) had oxygen consumption and duration in the vigorous-intensity zone between that of moderate-intensity continuous exercise (MICE) and high-intensity interval exercise (HIIE). In terms of affective responses, VIIE had higher post-exercise enjoyment. These findings suggest that VIIE could be a suitable alternative to HIIE and MICE.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tuula Tolvanen, Kari Kalliokoski, Simona Malaspina, Anna Kuisma, Salla Lahdenpohja, Ernst J. Postema, Matthew P. Miller, Mika Scheinin
Summary: The study investigated the safety, biodistribution, and internal radiation dosimetry of a novel F-18-labeled radiohybrid PSA imaging agent in healthy volunteers, showing favorable results for PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Neurosciences
Lihua Sun, Jing Tang, Heidi Liljenback, Aake Honkaniemi, Jenni Virta, Janne Isojarvi, Tomi Karjalainen, Tatu Kantonen, Pirjo Nuutila, Jarmo Hietala, Valtteri Kaasinen, Kari Kalliokoski, Jussi Hirvonen, Harry Scheinin, Semi Helin, Kim Eerola, Eriika Savontaus, Emrah Yatkin, Juha O. Rinne, Anne Roivainen, Lauri Nummenmaa
Summary: The study found that both humans and rats exhibit significant seasonal variations in cerebral MOR availability, primarily associated with seasonal changes in photoperiod. Changes in daylength were shown to influence MOR availability in the brain, impacting behaviors and physiological responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Dermatology
Esa Soppi, Juhani Knuuti, Kari Kalliokoski
Summary: This study investigated the pathophysiological cascade of pressure ulcer development, finding that the MPA mattress support surface had mechanobiological properties that counteracted tissue deformation and may prevent PUs.
JOURNAL OF WOUND CARE
(2021)
Article
Oncology
Simona Malaspina, Pekka Taimen, Markku Kallajoki, Vesa Oikonen, Anna Kuisma, Otto Ettala, Kalle Mattila, Peter J. Bostroem, Heikki Minn, Kari Kalliokoski, Ernst J. Postema, Matthew P. Miller, Mika Scheinin
Summary: The study evaluated the tracer uptake and lesion detectability of F-18-radiohybrid (rh)PSMA-7.3 in patients with prostate cancer. The results showed that F-18-rhPSMA-7.3 PET/CT demonstrated good detection of primary and metastatic PCa lesions, especially lesions with GS >= 4 + 3/GG >= 3.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Sport Sciences
Tiina Saanijoki, Tatu Kantonen, Laura Pekkarinen, Kari Kalliokoski, Jussi Hirvonen, Tuulia Malen, Lauri Tuominen, Jetro J. Tuulari, Eveliina Arponen, Pirjo Nuutila, Lauri Nummenmaa
Summary: Cardiorespiratory fitness and physical activity level are associated with opioid release and neuroadaptation within the mu-opioid receptor system in the brain. Higher self-reported physical activity level predicts greater opioid release after high-intensity interval training, and both maximal oxygen uptake and physical activity level are associated with a larger decrease in mu-opioid receptor binding after exercise in reward- and cognitive-related brain regions.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Sport Sciences
Taru Garthwaite, Tanja Sjoros, Saara Laine, Henri Vaha-Ypya, Eliisa Loyttyniemi, Harri Sievanen, Noora Houttu, Kirsi Laitinen, Kari Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka Heinonen
Summary: Reducing sedentary behavior and increasing light-intensity and moderate-to-vigorous physical activity can improve cardiometabolic biomarkers in adults with metabolic syndrome.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Sport Sciences
Chris Mawhinney, Ilkka Heinonen, David A. Low, Chunlei Han, Helen Jones, Kari K. Kalliokoski, Anna Kirjavainen, Jukka Kemppainen, Valter Di Salvo, Lorenzo Lolli, N. Tim Cable, Warren Gregson
Summary: The study revealed that lower temperature CWI resulted in decreased global quadriceps muscle perfusion, while higher temperature CWI did not have an effect. The effects of CWI on specific regions of muscle perfusion varied based on the temperature.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Endocrinology & Metabolism
Laura Pekkarinen, Tatu Kantonen, Eleni Rebelos, Aino Latva-Rasku, Prince Dadson, Tomi Karjalainen, Marco Bucci, Kari Kalliokoski, Kirsi Laitinen, Noora Houttu, Anna K. Kirjavainen, Johan Rajander, Tapani Roennemaa, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study investigates alterations in brain glucose uptake, insulin action in the brain-liver axis, and whole-body insulin sensitivity in young adults in a pre-obese state.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Sport Sciences
Eero A. Haapala, Tanja Sjoros, Saara Laine, Taru Garthwaite, Petri Kallio, Maria Saarenhovi, Henri Vaha-Ypya, Eliisa Loyttyniemi, Harri Sievanen, Noora Houttu, Kirsi Laitinen, Kari Kalliokoski, Juhani Knuuti, Tommi Vasankari, Ilkka H. Heinonen
Summary: The study suggests that using BM-1 as a scaling factor can confound the association between CRF and cardiometabolic risk in overweight/obese adults with metabolic syndrome.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2022)
Article
Sport Sciences
Tanja Sjoros, Saara Laine, Taru Garthwaite, Henri Vaha-Ypya, Eliisa Loyttyniemi, Mikko Koivumaki, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Harri Sievanen, Tommi Vasankari, Juhani Knuuti, Ilkka H. A. Heinonen
Summary: This study aimed to investigate whether a reduction in daily sedentary behavior improves insulin sensitivity in adults with metabolic syndrome. The results showed that reducing sedentary behavior by 40 minutes per day, while increasing moderate-to-vigorous physical activity by 20 minutes per day, resulted in slightly decreased fasting insulin levels, but had no effects on insulin sensitivity or body adiposity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Sport Sciences
Taru Garthwaite, Tanja Sjoros, Saara Laine, Mikko Koivumaki, Henri Vaha-Ypya, Olli Eskola, Johan Rajander, Petri Kallio, Maria Saarenhovi, Eliisa Loyttyniemi, Harri Sievanen, Noora Houttu, Kirsi Laitinen, Kari Kalliokoski, Tommi Vasankari, Juhani Knuuti, Ilkka Heinonen
Summary: The objective of this study was to investigate the associations between sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake. Sedentary time, physical activity, steps, and VO(2)max were found to be associated with muscle glucose uptake, but these associations became non-significant when adjusted for body fat-%. Therefore, body composition is a more important determinant of muscle glucose uptake in this population.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Sport Sciences
Jooa Norha, Tanja Sjoros, Taru Garthwaite, Saara Laine, Maria Saarenhovi, Petri Kallio, Kirsi Laitinen, Noora Houttu, Henri Vaha-Ypya, Harri Sievanen, Eliisa Loyttyniemi, Tommi Vasankari, Juhani Knuuti, Kari K. Kalliokoski, Ilkka H. A. Heinonen
Summary: A study on adults with metabolic syndrome found that reducing sedentary behavior without adding exercise training did not significantly improve maximal oxygen uptake (VO2max). However, increasing daily step count may increase VO2max.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Endocrinology & Metabolism
Tanja Sjoeros, Saara Laine, Taru Garthwaite, Henri Vaha-Ypya, Mikko Koivumaki, Olli Eskola, Eliisa Loyttyniemi, Noora Houttu, Kirsi Laitinen, Kari K. Kalliokoski, Harri Sievanen, Tommi Vasankari, Juhani Knuuti, Ilkka H. A. Heinonen
Summary: Interventions aimed at reducing sedentary behavior for 1 hour per day can improve insulin sensitivity in the weight-bearing thigh muscles of sedentary adults with metabolic syndrome. However, this intervention does not have a significant impact on overall muscle and whole body insulin sensitivity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Laura Pekkarinen, Tatu Kantonen, Vesa Oikonen, Merja Haaparanta-Solin, Richard Aarnio, Alex M. Dickens, Annie von Eyken, Aino Latva-Rasku, Prince Dadson, Anna K. Kirjavainen, Johan Rajander, Kari Kalliokoski, Tapani Roennemaa, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study aimed to investigate CB1R availability in peripheral tissue and brain in young men with overweight versus lean men. The results suggest endocannabinoid dysregulation already in the preobesity state, as CB1R availability in abdominal adipose tissue was lower in the high-risk group and correlated with insulin sensitivity and unfavorable lipid profile.