A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy

(2014) Seo Yeon Woo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-Hydroxy-3,6,7,8,3′4′-hexamethoxyflavone inhibits nitric oxide production in lipopolysaccharide-stimulated BV2 microglia via NF-κB suppression and Nrf-2-dependent heme oxygenase-1 induction

(2013) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease

(2013) Fabio Blandini   Journal of Neuroimmune Pharmacology

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease

(2013) Fabiana Morroni et al.   NEUROTOXICOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

(2013) Adam J. Pawson et al.   NUCLEIC ACIDS RESEARCH

Role of Oxidative Stress in Parkinson's Disease

(2013) Onyou Hwang   Experimental Neurobiology

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

(2012) Navneet Ammal Kaidery et al.   ANTIOXIDANTS & REDOX SIGNALING

Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease

(2012) Sa Suk Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anti-Inflammatory Trends of 1, 3-Diphenyl-2-propen-1-one Derivatives

(2012) Syed Nasir Abbas Bukhari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinson's disease induced by MPTP

(2011) Hyo Jin Son et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells

(2011) Kyungmi Koh et al.   JOURNAL OF NEUROIMMUNOLOGY

Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice

(2011) John D. Clarke et al.   PHARMACEUTICAL RESEARCH

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential

(2010) Ananta Paine et al.   BIOCHEMICAL PHARMACOLOGY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells

(2010) Ik-Soo Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

(2010) Nadia G. Innamorato et al.   PLoS One

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

(2010) R. P. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Doxycycline is Neuroprotective Against Nigral Dopaminergic Degeneration by a Dual Mechanism Involving MMP-3

(2009) Yuri Cho et al.   NEUROTOXICITY RESEARCH

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

(2008) Wen Lin et al.   BIOCHEMICAL PHARMACOLOGY

Modulating GSH Synthesis Using Glutamate Cysteine Ligase Transgenic and Gene-Targeted Mice

(2008) Dianne Botta et al.   DRUG METABOLISM REVIEWS

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE