Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 8, Issue 8, Pages 755-766Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138955708784912120
Keywords
c-jun-N-Terminal Kinase (JNK); mitogen activated protein (MAP); benzothiazole pyrimidines; benzothien-2-yl-amides; indazoles; aminopyrimidines; aminopyridines; quinolines
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Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.
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