Review
Medicine, General & Internal
Abd-Elgawad Radi, Maha Ragaa Abd-Ellatief
Summary: This article reviews the diversity of electrochemical aptasensors for target analyte detection, covering strategies of aptamer immobilization, types of sensors, and applications for clinically important biomarkers.
Review
Medicine, General & Internal
Phillip C. Nguyen, Hannah Stevens, Karlheinz Peter, James D. McFadyen
Summary: Patients with submassive pulmonary embolism (PE) have worse outcomes than those with standard-risk PE, and the use of systemic thrombolytic therapy in submassive PE has not shown clear benefits. Interest remains in optimizing thrombolysis, with new therapies in preclinical and early clinical trials being investigated.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Francesco Emma, Giovanni Montini, Marco Pennesi, Licia Peruzzi, Enrico Verrina, Bianca Maria Goffredo, Fabrizio Canalini, David Cassiman, Silvia Rossi, Elena Levtchenko
Summary: Early diagnosis and effective therapy are crucial for the prognosis and quality of life of patients with nephropathic cystinosis. Accurate monitoring of intracellular cystine concentration is essential for successful treatment. Cystine depletion is the only available treatment and should be started immediately to slow down organ damage. New biomarkers play a significant role in disease management, from diagnosis to treatment.
Article
Immunology
Malgorzata Proboszcz, Krzysztof Goryca, Patrycja Nejman-Gryz, Tadeusz Przybylowski, Katarzyna Gorska, Rafal Krenke, Magdalena Paplinska-Goryca
Summary: The study investigated distinct disease profiles based on clinical, cellular, and molecular data from patients with mild-to-moderate obstructive pulmonary diseases. Five key variables were identified to differentiate between asthma and COPD, and cluster analysis revealed two main clusters within the combined samples of asthma and COPD patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Joan M. Cook-Mills, Samantha H. Averill, Jacquelyn D. Lajiness
Summary: Asthma and allergic disease are the result of interactions between environmental exposures and genetics. Different isoforms of vitamin E have opposite functions in regulating allergic inflammation and development of allergic disease, which may explain the varying outcomes of vitamin E on allergies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Medicine, General & Internal
Damini Saxena, Ikuyo Imayama, Muhammad Adrish
Summary: Asthma and obstructive sleep apnea are common conditions with high costs. They have a bidirectional relationship, and asthma may lower the arousal threshold in obstructive sleep apnea. Additionally, obstructive sleep apnea is associated with worse asthma severity, increased exacerbation frequency, and poor quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Grzegorz Kardas, Michal Panek, Piotr Kuna, Piotr Damianski, Maciej Kupczyk
Summary: Clinical data suggest that monoclonal antibody treatments targeting key inflammatory cytokines in asthma can reduce exacerbation rates, improve lung function, increase asthma control, and enhance quality of life. However, there is still a need for additional therapies as some patients do not respond well to existing antibodies. Research is ongoing to develop biologics targeting different immunological pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yue Yu, Ailin Yang, Ganggang Yu, Haoyan Wang
Summary: This review explores the relationship between ER stress and UPR with COPD, as well as drug intervention strategies targeting the UPR pathway in COPD. By analyzing other cellular processes, new therapeutic approaches and preventive measures for COPD are investigated.
Review
Medicine, General & Internal
Shahrokh Javaheri, Sogol Javaheri
Summary: This review provides a comprehensive overview of the current knowledge of obstructive sleep apnea (OSA) and congestive heart failure (HF), including the pathophysiologic mechanisms, observational data, treatment options, and future research needs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Joe Ibrahim, Marc Peeters, Guy Van Camp, Ken Op de Beeck
Summary: The recent increase in cancer biomarker research has led to new insights in the field. Technological breakthroughs, such as long read sequencing and microarrays, have enabled high throughput profiling of biomarkers, while advances in bioinformatic tools have made reliable and accurate biomarkers a reality. These changes have renewed interest in biomarker research and provided opportunities for enhancing cancer management and early disease detection.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Yu Wu, Qi Zhou, Fangyue Guo, Mingming Chen, Xufeng Tao, Deshi Dong
Summary: Pancreatic cancer is a highly malignant tumor in the digestive system with limited specific interventions available. The S100 protein family, expressed only in vertebrates, has potential as a biomarker for cancer progression and prognosis. Understanding the functions of S100 proteins could lead to new therapeutic targets for preventing or treating pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biology
Zhangsong Wu, Jinjian Liu, Ruixiang Dai, Song Wu
Summary: The treatment strategy for bladder cancer has evolved with the introduction of immunotherapy, but only a limited number of patients benefit from it, and there are challenges with immune-related adverse events. If response rates improve and adverse events are managed better, immunotherapy could potentially revolutionize the landscape of urothelial carcinoma therapeutics.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Allergy
Ann-Marie M. Schoos, Bright I. Nwaru, Magnus P. Borres
Summary: This review provides an overview of furry mammal allergens as important sources of allergens, discusses the application of component resolved diagnostics beyond traditional methods, and highlights the clinical utility of CRD in predicting asthma risk and disease severity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Medical Laboratory Technology
Andrea Vianello, Gabriella Guarnieri, Alessia Achille, Federico Lionello, Sara Lococo, Martina Zaninotto, Marco Caminati, Gianenrico Senna
Summary: This study examines the pathogenesis of airway and lung parenchymal remodeling and explores if serum biomarkers could identify severe asthmatic patients who may develop fixed airway obstruction (FAO). The study suggests that Krebs von den Lungen-6 (KL-6) may serve as a diagnostic biomarker of lung structural damage in SA.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Nutrition & Dietetics
Katherine J. Li, Kathryn J. Burton-Pimentel, Guy Vergeres, Edith J. M. Feskens, Elske M. Brouwer-Brolsma
Summary: Unhealthy diets contribute to the burden of non-communicable diseases. The consumption of fermented foods has emerged as an important dietary strategy for improving cardiometabolic health. This review provides an overview of fermented foods, their types and qualities, possible mechanisms between fermented food consumption and cardiometabolic health, and the current state of epidemiological evidence on this topic.
FRONTIERS IN NUTRITION
(2022)
