Review
Chemistry, Multidisciplinary
Namrata Singh, G. R. Sherin, Govindasamy Mugesh
Summary: Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted significant interest in biomedical applications, particularly in oxidative stress-mediated disorders. The challenge lies in designing nanozymes that can selectively differentiate between physiological oxidative stress and pathological oxidative stress and mediate appropriate redox reactions in cells, tissues, and organs. This review summarizes the advancements in redox-active nanozymes and their therapeutic significance in various disease models, such as cancer, neurodegeneration, and cardiovascular diseases. It also discusses the future prospects and challenges associated with the biomedical applications of nanozymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Falin He, Qiang Liu, Mingyang Jing, Jingqiang Wan, Chengqian Huo, Wansong Zong, Jingchun Tang, Rutao Liu
Summary: Phenanthrene (PHE) is a significant organic compound found widely in soil, which can induce oxidative stress and cytotoxicity in earthworm coelomocytes at high concentrations. The interaction between PHE and antioxidant enzymes SOD/CAT plays a role in these toxic effects.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Zhihan Cui, Falin He, Xiangxiang Li, Yuze Li, Chengqian Huo, Hao Wang, Yuntao Qi, Guang Tian, Wansong Zong, Rutao Liu
Summary: This study reveals the response mechanisms of SOD/CAT under the regulation of TCC-induced oxidative stress and sheds new light on the toxic pathways of exogenous pollutants on antioxidant-related proteins function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Horticulture
Mohammad Pourebrahimi, Saeid Eshghi, Asghar Ramezanian, Shiva Faghih
Summary: High salinity levels can lead to various adverse effects on plants, including osmotic stress and nutritional disorders. In this study, the combined use of hydrogen sulfide and selenium compounds was found to alleviate the negative effects of salt stress on strawberry yield and enhance the antioxidant and nutritional quality of the fruits.
SCIENTIA HORTICULTURAE
(2023)
Review
Biotechnology & Applied Microbiology
Giannina Espina, Joaquin Atalah, Jenny M. Blamey
Summary: The demand for enzymes in industrial processes is increasing globally, with extremophilic enzymes showing higher stability and activity, leading to diverse potential applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anthony Al Khoury, Andre El Khoury, Ophelie Rocher, Pamela Hindieh, Olivier Puel, Richard G. G. Maroun, Ali Atoui, Jean-Denis Bailly
Summary: Plant extracts from mate, rosemary, and green tea exhibit anti-AFB1 activity, which is correlated with their phenolic content and radical scavenging capacity. Rutin may be responsible for the anti-mycotoxin effect.
Review
Biochemistry & Molecular Biology
Pavlina Hemerkova, Martin Valis
Summary: ALS is a neurodegenerative disease that affects motor neurons and currently has no cure. Free oxygen radicals are known to play a role in the pathogenesis of ALS, while antioxidant enzymes like SOD1 are crucial for antioxidant protection.
Review
Biochemistry & Molecular Biology
Yu Ah Hong, Cheol Whee Park
Summary: Reactive oxygen and nitrogen species play crucial roles in kidney injuries, making antioxidant agents, especially catalytic antioxidants that mimic antioxidant enzymes, effective in combating oxidative stress-related kidney diseases. Research has shown the effectiveness of several catalytic antioxidants in treating disease models associated with oxidative stress.
Article
Environmental Sciences
Paolo Pastorino, Elisabetta Pizzul, Damia Barcelo, Maria Cesarina Abete, Gabriele Magara, Paola Brizio, Rosa Avolio, Marco Bertoli, Alessandro Dondo, Marino Prearo, Antonia Concetta Elia
Summary: This study investigated the oxidative stress ecology in Danube barbel from the Barbucina creek, analyzing the levels of antioxidant biomarkers and trace elements in the fish. Results indicated a significant association between certain trace elements and enzyme activity, suggesting their role as stressors in the aquatic environment. The study provides insights into the biochemical defensive response of fish to environmental disturbances, advancing our understanding of the effects of environmental factors on oxidative stress in aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Diana Ofelia Lopez-Cantu, Reyna Berenice Gonzalez-Gonzalez, Elda M. Melchor-Martinez, Saul Antonio Hernandez Martinez, Rafael G. Araujo, Lizeth Parra-Arroyo, Juan Eduardo Sosa-Hernandez, Roberto Parra-Saldivar, Hafiz M. N. Iqbal
Summary: Nanozymes, artificial enzymes based on engineered nanomaterials, have been developed to overcome inherent drawbacks of natural enzymes, showing great potential for various applications. Carbon dots have garnered significant attention for their high catalytic activity and biocompatibility, serving as possible alternatives in biomedical and environmental fields. Studies have shown that carbon dots can mimic different oxidoreductases, exhibiting multiple enzyme-like activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Fatemeh Najafi, Gholamreza Kavoosi, Roghayeh Siahbalaei, Amina Kariminia
Summary: The study demonstrated that Agastache foeniculum essential oil and oil fraction have inhibitory effects on oxidative stress induced by hyperglycemia and inflammation, mainly by regulating the activity and expression levels of relevant enzymes to reduce the production of oxidative stress. At the molecular level, the components of AFEO and AFoil were found to interact with corresponding proteins through molecular docking, showing antioxidant and anti-diabetic effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Article
Veterinary Sciences
Rejane Santos Sousa, Caroline Santos Sousa, Francisco Leonardo Costa Oliveira, Paulo Ricardo Firmino, Isadora Karolina Freitas Sousa, Valeria Veras Paula, Nohora Mercado Caruso, Enrico Lippi Ortolani, Antonio Humberto Hamad Minervino, Raimundo Alves Barreto-Junior
Summary: Blood loss in sheep can cause clinical, hematological, blood gas, and biochemical alterations, leading to oxidative stress and reduced antioxidant activity.
VETERINARY SCIENCES
(2022)
Article
Environmental Sciences
Mustafa Bilgin, Esin Uluturhan, Enis Darilmaz, Selma Katalay
Summary: This study investigated the effects of metal accumulation in Sparus aurata and Chelon labrosus in the Izmir Bay using biomarkers. The results showed higher levels of metals and biomarkers in the liver and gill tissues compared to muscle tissues. Biochemical biomarkers were found to be significant predictors of metal bio-accumulation, and histological changes were observed in the liver and gills.
MARINE POLLUTION BULLETIN
(2023)
Article
Horticulture
Naushad Alam, Waseem Siddique, Manoj K. Mishra, Anukriti Pandey, Dhermendra K. Purshottam, Khuraijam Jibankumar Singh, Shri Krishna Tewari, Debasis Chakrabarty
Summary: This study aims to develop an affordable and easy-to-use hydroponic system for the conservation and mass production of four Hoya species. The optimal medium for root growth was determined to be 1/2 MS + IBA (2.5μM). Zinc sulfate (ZnSO4) at concentrations of 25, 50, 100, 150, and 200μM was found to improve root number. The findings of this study are important for the conservation and mass propagation of Hoya species.
SCIENTIA HORTICULTURAE
(2023)
Review
Pharmacology & Pharmacy
Yingmin Liang, Judith C. W. Mak
Summary: Asthma and COPD are obstructive lung diseases characterized by chronic inflammation and increased mucus production, with a significant unmet medical need despite recent advances. Lack of new safe and effective therapies, due to few drug candidates, hinders progress in respiratory medicine. The high burden of asthma and COPD as leading causes of death globally necessitates the development of more effective treatments.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Integrative & Complementary Medicine
K. H. Chan, Y. Y. S. Tsoi, M. McCall
Summary: A systematic review of 100 randomized controlled trials revealed that combining Chinese herbal medicine with conventional treatment improves lung function, reduces exacerbation rates, and enhances COPD assessment test and TCM syndrome score in stable COPD patients. While no serious adverse events were reported, further studies with larger sample sizes are needed to confirm these findings.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Respiratory System
Henry W. Ainge-Allen, Brendon J. Yee, Mary S. M. Ip
Summary: Obstructive sleep apnoea (OSA) affects one-seventh of the world's population, with treatment improving daytime sleepiness and quality of life even in mild cases. Recent modifications to uvulopalatopharyngoplasty may make it more widely applicable in selected OSA patients, while diet and exercise can impact the severity of sleep apnoea independently of weight loss. Insomnia has become more common during the COVID-19 pandemic.
Article
Respiratory System
Wang Chun Kwok, Anthony Raymond Tam, James Chung Man Ho, David Chi Leung Lam, Terence Chi Chun Tam, King Pui Florence Chan, Julie Kwan Ling Wang, Mary Sau Man Ip, Ivan Fan Ngai Hung
Summary: Chronic illnesses, including asthma, have been found to be poor prognostic factors associated with severe illness and complications in COVID-19 infection. This study showed that regardless of asthma severity, it is an independent prognostic factor for COVID-19 and is associated with more severe disease and complications.
CLINICAL RESPIRATORY JOURNAL
(2022)
Article
Environmental Sciences
Yingmin Liang, Pak Hin Chu, Linwei Tian, Kin Fai Ho, Mary Sau Man Ip, Judith Choi Wo Mak
Summary: This study found that PM2.5 leads to the opening of mitochondrial permeability transition pore (mPTP), resulting in cell apoptosis and mitochondrial dysfunction. The opening of mPTP is achieved through upregulation of VDAC channel and reduction in nuclear expression of PPARgamma and PGC-1 alpha. Furthermore, the use of mPTP targeting compounds can inhibit PM2.5-induced mPTP opening and cell apoptosis, and preserve mitochondrial function.
ENVIRONMENTAL POLLUTION
(2022)
Article
Medicine, General & Internal
Si-Yeung Yu, Mary Sau-Man Ip, Xue Li, Ka-Shing Cheung, Qing-Wen Ren, Mei-Zhen Wu, Hang-Long Li, Pui-Fai Wong, Hung-Fat Tse, Kai-Hang Yiu
Summary: Low-dose aspirin use is associated with a lower risk of lung carcinoma and lung carcinoma-related mortality among COPD patients, but it also increases the risk of bleeding, particularly hemoptysis.
Article
Chemistry, Multidisciplinary
Yuan He, Chang Liu, Run Han, Yingmin Liang, Judith Choi Wo Mak, Yinghao Zhu, Haifeng Li, Ying Zheng
Summary: Pulmonary delivery is an effective strategy for treating local respiratory diseases. In this study, a lipid-coated genistein nanocrystals formulation was developed to enhance drug concentration in the lungs. The formulation exhibited reduced drug release rate, decreased intracellular uptake and transcellular transport, and impeded macrophages clearance. In vivo studies showed improved lung retention and reduced systemic absorption. This research suggests that the lipid-coated nanocrystals formulation is suitable for enhancing local pulmonary delivery.
CHINESE CHEMICAL LETTERS
(2023)
Editorial Material
Respiratory System
Mary S. M. Ip, Huaping Dai
Article
Respiratory System
Pei-Hang Xu, Daniel Y. T. Fong, Macy M. S. Lui, David C. L. Lam, Mary Sau Man Ip
Summary: This study found that in Chinese patients, sleep time with oxygen saturation <90% (TST90) and mean heart rate related to obstructive sleep apnoea (OSA) - not apnoea-hypopnoea index (AHI) - were robust predictors of major adverse cardiovascular events (MACEs). Furthermore, a subgroup with a clinical phenotype was identified, where regular CPAP use was associated with a lower risk of MACEs.
Review
Clinical Neurology
Yang Ji, Yingmin Liang, Judith C. W. Mak, Mary S. M. Ip
Summary: Obesity is a strong risk factor for both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). Intermittent hypoxia plays an important role in the development of NAFLD in OSA. Understanding the roles of obesity and intermittent hypoxia in NAFLD is crucial for gaining more knowledge about the health consequences of OSA and devising effective therapeutic strategies.
Article
Biochemistry & Molecular Biology
Yang Ji, Yingmin Liang, Pak Hin Chu, Mengqin Ge, Sze Chun Yeung, Mary Sau Man Ip, Judith Choi Wo Mak
Summary: This study suggests that intermittent hypoxia (IH) may lead to liver injury by modulating hepatic CD36 expression in lean and diet-induced obese mice.
BIOMEDICAL JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Chang Liu, Yihan Liu, Long Xi, Yuan He, Yingmin Liang, Judith Choi Wo Mak, Shirui Mao, Zhenping Wang, Ying Zheng
Summary: This study investigates the interactions between liposomes with different charges and key phagocytes in acute lung injury (ALI) models, as well as their biofate and overall anti-inflammatory effect. The results show that neutrophils have a higher uptake capacity for cationic liposomes, while alveolar macrophages preferentially uptake anionic liposomes. Both alveolar macrophages and infiltrated neutrophils contribute to the lung retention of inhaled liposomes in ALI models. Finally, inhaled neutrophil preferential liposomes exhibit optimal anti-inflammatory effect due to prolonged circulation times.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Chang Liu, Long Xi, Yihan Liu, Judith Choi Wo Mak, Shirui Mao, Zhenping Wang, Ying Zheng
Summary: This study developed an inhalable biomimetic sequential drug-releasing nanoplatform for the combinatorial treatment of acute lung injury (ALI). The nanoplatform effectively inhibited the coordinated action of neutrophils and macrophages, modulated the hyper-inflammatory condition, and promoted lung tissue repair. The dual-stage drug release behavior facilitated down-regulation of pro-inflammatory cytokines and remodeling of lung immune homeostasis.
Review
Respiratory System
Raja Dhar, Chin Kook Rhee, Diahn-Warng Perng, Koichi Fukunaga, Mary Sau-Man Ip, Siwasak Juthong, Mariko Siyue Koh, Jing Li, Shubham Sharma, Wiwien Heru Wiyono
Summary: Most patients with asthma can manage their condition effectively with inhaled medications. However, those with severe or uncontrolled asthma may require systemic corticosteroids, which can have long-term adverse health outcomes. Studies suggest that there is an overuse of systemic corticosteroids in asthma management globally, including Asia, and coordinated changes are needed to reduce this burden.
Article
Respiratory System
Wang Chun Kwok, Ting Fung Ma, James Chung Man Ho, David Chi Leung Lam, Ko Yung Sit, Mary Sau Man Ip, Timmy Wing Kuk Au, Terence Chi Chun Tam
Summary: This study developed a prediction model based on readily available clinical information to accurately predict disease recurrence in stage I adenocarcinoma patients, which can help personalize follow-up strategies and future adjuvant therapy.