Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca2+entry pathways

Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line

(2014) H.-T. Ma et al.   JOURNAL OF IMMUNOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2

(2011) Mankit Law et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating

(2011) Judith Bergsmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microwave-Assisted and Continuous Flow Multistep Synthesis of 4-(Pyrazol-1-yl)carboxanilides

(2011) David Obermayer et al.   JOURNAL OF ORGANIC CHEMISTRY

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes

(2011) M. Poteser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions

(2011) Kwong Tai Cheng et al.   PLOS BIOLOGY

Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils

(2010) Michael D. Salmon et al.   CELLULAR IMMUNOLOGY

TRPC channels as STIM1-regulated SOCs

(2010) Joseph P. Yuan et al.   Channels

Pharmacological Modulation of Diacylglycerol-Sensitive TRPC3/6/7 Channels

(2010) Christian Harteneck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Pharmacology of receptor operated calcium entry in human neutrophils

(2010) Michael D. Salmon et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Transient Receptor Potential Canonical 3 (TRPC3) Mediates Thrombin-Induced Astrocyte Activation and Upregulates Its Own Expression in Cortical Astrocytes

(2010) H. Shirakawa et al.   JOURNAL OF NEUROSCIENCE

High-Speed Microwave-Assisted Synthesis of the Trifluoromethylpyrazol-Derived Canonical Transient Receptor Potential (TRPC) Channel Inhibitor Pyr3

(2009) Toma N. Glasnov et al.   ChemMedChem

Small-Molecule Inhibitors of Store-Operated Calcium Entry

(2009) Zachary K. Sweeney et al.   ChemMedChem

Physiology and pathophysiology of canonical transient receptor potential channels

(2009) Joel Abramowitz et al.   FASEB JOURNAL

CRAC channels and Ca2+signaling in mast cells

(2009) Joseph Di Capite et al.   IMMUNOLOGICAL REVIEWS

Cell-Cell Contact Formation Governs Ca2+Signaling by TRPC4 in the Vascular Endothelium

(2009) Annarita Graziani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPC3 Regulates Agonist-stimulated Ca2+Mobilization by Mediating the Interaction between Type I Inositol 1,4,5-Trisphosphate Receptor, RACK1, and Orai1

(2009) Geoffrey E. Woodard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

(2009) S. Kiyonaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

(2008) Yasuhiro Yonetoku et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sustained Activation of the Tyrosine Kinase Syk by Antigen in Mast Cells Requires Local Ca2+Influx through Ca2+Release-activated Ca2+Channels

(2008) Siaw Wei Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai1 Mediates the Interaction between STIM1 and hTRPC1 and Regulates the Mode of Activation of hTRPC1-forming Ca2+Channels

(2008) Isaac Jardin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry

(2008) Wayne I. DeHaven et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Clustering of STIM1 with Orai1/CRACM1 at the Plasma Membrane Depends Dynamically on Depletion of Ca2+ Stores and on Electrostatic Interactions

(2008) Nathaniel Calloway et al.   MOLECULAR BIOLOGY OF THE CELL

The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels

(2007) Rainer Schindl et al.   CELL CALCIUM

Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate

(2007) Loïc Lemonnier et al.   CELL CALCIUM