Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta

(2008) Federica Lodi et al.   ATHEROSCLEROSIS

Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor

(2008) Cui Qing Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Macrophage as a Target of Quercetin Glucuronides in Human Atherosclerotic Arteries

(2008) Yoshichika Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells

(2007) Sandra Tribolo et al.   ATHEROSCLEROSIS

Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: Lack of association between antioxidant and lipoxygenase inhibitory activity

(2007) Wai Mun Loke et al.   BIOCHEMICAL PHARMACOLOGY

Role of cGMP-dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries

(2007) D Dou et al.   BRITISH JOURNAL OF PHARMACOLOGY