Haematopoietic development and leukaemia in Down syndrome

RecurrentGATA1mutations in Diamond-Blackfan anaemia

(2014) Joakim Klar et al.   BRITISH JOURNAL OF HAEMATOLOGY

miR-99a/100 125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF  and Wnt signaling

(2014) S. Emmrich et al.   GENES & DEVELOPMENT

Domains of genome-wide gene expression dysregulation in Down’s syndrome

(2014) Audrey Letourneau et al.   NATURE

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

(2014) Andrew A Lane et al.   NATURE GENETICS

How I treat ALL in Down's syndrome: pathobiology and management

(2013) S. Izraeli et al.   BLOOD

Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome

(2013) T. Toki et al.   BLOOD

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder

(2013) Y. Birger et al.   BLOOD

Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome

(2013) S. I. Nikolaev et al.   BLOOD

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

(2013) T. D. Buitenkamp et al.   BLOOD

Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes

(2013) S. Malinge et al.   BLOOD

GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia

(2013) I. Roberts et al.   BLOOD

Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia

(2013) Noa Tal et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia

(2013) A Maroz et al.   LEUKEMIA

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

The landscape of somatic mutations in Down syndrome–related myeloid disorders

(2013) Kenichi Yoshida et al.   NATURE GENETICS

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

(2013) Susan M. Gribble et al.   PLoS One

Clinical characteristics and outcome of refractory/relapsed myeloid leukemia in children with Down syndrome

(2012) T. Taga et al.   BLOOD

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

(2012) Sébastien Malinge et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia

(2012) Vijay G. Sankaran et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic features in acute megakaryoblastic leukemia in children without Down syndrome: a report from the AML02 multicenter trial and the Children’s Oncology Group Study POG 9421

(2012) M M O'Brien et al.   LEUKEMIA

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

(2012) A. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

(2012) S. T. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells

(2012) G. A. MacLean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia

(2011) K. A. Alford et al.   BLOOD

Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971

(2011) A. S. Gamis et al.   BLOOD

Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias

(2011) Chen Shochat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

(2010) K. A. Alford et al.   BLOOD

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

(2010) S. Schnittger et al.   BLOOD

GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells

(2010) S. Yu et al.   BLOOD

Peripheral blood cell counts in infants with Down's syndrome

(2010) S. M. Kivivuori et al.   CLINICAL GENETICS

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Down Syndrome B-Lymphocyte Subpopulations, Intrinsic Defect or Decreased T-Lymphocyte Help

(2010) Ruud H J Verstegen et al.   PEDIATRIC RESEARCH

Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells

(2010) Song Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

(2009) S. Malinge et al.   BLOOD

RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia

(2009) H. Edwards et al.   BLOOD

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

(2009) A. P. Ng et al.   BLOOD

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

(2009) L. Hertzberg et al.   BLOOD

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

(2009) L. J. Russell et al.   BLOOD

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis

(2009) Anindita Roy et al.   BRITISH JOURNAL OF HAEMATOLOGY

ERG Is a Megakaryocytic Oncogene

(2009) S. Salek-Ardakani et al.   CANCER RESEARCH

Intrinsic defect of the immune system in children with Down syndrome: a review

(2009) M. A. A. Kusters et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Constitutional aneuploidy and cancer predisposition

(2009) I. Ganmore et al.   HUMAN MOLECULAR GENETICS

Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53

(2009) N Gefen et al.   LEUKEMIA

Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia

(2009) Charles G Mullighan et al.   NATURE GENETICS

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trisomy 21 tilts the balance

(2008) S. Izraeli   BLOOD

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

(2008) C. L. Carmichael et al.   BLOOD

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

(2008) O. Tunstall-Pedoe et al.   BLOOD

Trisomy 21 enhances human fetal erythro-megakaryocytic development

(2008) S. T. Chou et al.   BLOOD

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

(2008) J.-H. Klusmann et al.   BLOOD

Hematological abnormalities in adult patients with Down’s syndrome

(2008) S. McLean et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

(2008) Dani Bercovich et al.   LANCET

The role of parathyroid hormone and insulin-like growth factors in hematopoietic niches: Physiology and pharmacology

(2008) R.W. Garrett et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Acute Leukemias in Children with Down Syndrome

(2008) C. Michel Zwaan et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

(2007) G. Kirsammer et al.   BLOOD