Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

(2012) Sébastien Malinge et al.   JOURNAL OF CLINICAL INVESTIGATION

Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

(2012) A. Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells

(2012) G. A. MacLean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A transient definitive erythroid lineage with unique regulation of the  -globin locus in the mammalian embryo

(2011) K. E. McGrath et al.   BLOOD

Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

(2011) Christoph Bock et al.   CELL

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

(2011) Kitai Kim et al.   NATURE BIOTECHNOLOGY

A Novel Serum-Free Monolayer Culture for Orderly Hematopoietic Differentiation of Human Pluripotent Cells via Mesodermal Progenitors

(2011) Akira Niwa et al.   PLoS One

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

(2010) K. A. Alford et al.   BLOOD

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Female Human iPSCs Retain an Inactive X Chromosome

(2010) Jason Tchieu et al.   Cell Stem Cell

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

(2010) H. Lapillonne et al.   HAEMATOLOGICA

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

(2010) Jose M Polo et al.   NATURE BIOTECHNOLOGY

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

(2009) S. Malinge et al.   BLOOD

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis

(2009) O. Klimchenko et al.   BLOOD

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis

(2009) Anindita Roy et al.   BRITISH JOURNAL OF HAEMATOLOGY

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic and Endothelial Differentiation of Human Induced Pluripotent Stem Cells

(2009) Kyung-Dal Choi et al.   STEM CELLS

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

(2008) C. L. Carmichael et al.   BLOOD

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

(2008) O. Tunstall-Pedoe et al.   BLOOD

Trisomy 21 enhances human fetal erythro-megakaryocytic development

(2008) S. T. Chou et al.   BLOOD

Biologic properties and enucleation of red blood cells from human embryonic stem cells

(2008) S.-J. Lu et al.   BLOOD

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis

(2008) F. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette

(2008) Cesar A. Sommer et al.   STEM CELLS

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

(2007) G. Kirsammer et al.   BLOOD