New ways to separate Graft-versus-Host Disease and Graft-versus-Tumour effects after allogeneic haematopoietic stem cell transplantation

Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)

(2012) O. C. Goodyear et al.   BLOOD

Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

(2012) Ran Reshef et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

(2011) K. L. Hippen et al.   BLOOD

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL

(2011) A. M. Hanash et al.   BLOOD

Human regulatory T cells in allogeneic stem cell transplantation

(2011) S. N. Ukena et al.   BLOOD

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

(2011) A. Veerapathran et al.   BLOOD

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Ccr5 deficiency regulates the proliferation and trafficking of natural killer cells under physiological conditions

(2011) Ido D. Weiss et al.   CYTOKINE

Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation

(2011) Claire Roddie et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Enhancing graft-versus-leukemia after transplant: the rise of anti-cancer vaccines

(2011) Ana Brusic   Frontiers in Bioscience-Landmark

Alloreactive and leukemia-reactive T cells are preferentially derived from naive precursors in healthy donors: implications for immunotherapy with memory T cells

(2011) E. Distler et al.   HAEMATOLOGICA

The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

(2011) Shuichiro Takashima et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD103 Deficiency Prevents Graft-versus-Host Disease but Spares Graft-versus-Tumor Effects Mediated by Alloreactive CD8 T Cells

(2011) Kechang Liu et al.   PLoS One

Regulatory T Cells: Customizing for the Clinic

(2011) X. Wang et al.   Science Translational Medicine

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Genetic engineering of T cells for the immunotherapy of haematological malignancies

(2011) M. Casucci et al.   TISSUE ANTIGENS

Regulatory T cells: stability revisited

(2011) Samantha L. Bailey-Bucktrout et al.   TRENDS IN IMMUNOLOGY

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

(2010) R. Das et al.   BLOOD

Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells

(2010) J. M. Coghill et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Reduced-intensity conditioning allogeneic stem cell transplantation for older adults: is it the standard of care?

(2010) Brian L McClune et al.   CURRENT OPINION IN HEMATOLOGY

Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation

(2010) Astrid Menning et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

CD4+CD25+ Regulatory T Cell Depletion Improves the Graft-Versus-Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation

(2010) S. Maury et al.   Science Translational Medicine

Nonabsorbable Corticosteroids Use in the Treatment of Gastrointestinal Graft-versus-Host Disease

(2009) Rami B. Ibrahim et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Increase in FOXP3+ Regulatory T Cells in GVHD Skin Biopsies Is Associated with Lower Disease Severity and Treatment Response

(2009) Cristina Fondi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Chemokine Receptor CCR5 Mediates AlloImmune Responses in Graft-versus-Host Disease

(2009) Lisa A. Palmer et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors

(2009) O. Penack et al.   BLOOD

Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD)

(2009) Tinghua Cao et al.   CELLULAR IMMUNOLOGY

Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab

(2009) K. Matthews et al.   HAEMATOLOGICA

Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease

(2009) John Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expansion of Allospecific Regulatory T Cells After Anergized, Mismatched Bone Marrow Transplantation

(2009) J. K. Davies et al.   Science Translational Medicine

Organ-derived dendritic cells have differential effects on alloreactive T cells

(2008) T. D. Kim et al.   BLOOD

Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease

(2008) R. Das et al.   BLOOD

Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow

(2008) U. Palendira et al.   BLOOD

Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells

(2008) B. E. Anderson et al.   BLOOD

Prophylaxis regimens for GVHD: systematic review and meta-analysis

(2008) R Ram et al.   BONE MARROW TRANSPLANTATION

Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation

(2008) A H Elmaagacli et al.   BONE MARROW TRANSPLANTATION

Donor Regulatory T Cells Identified by FoxP3 Expression but Also by the Membranous CD4+CD127low/neg Phenotype Influence Graft-versus-tumor Effect After Donor Lymphocyte Infusion

(2008) Yosr Hicheri et al.   JOURNAL OF IMMUNOTHERAPY

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4posCD25high T Cells for Immunotherapy

(2008) Jorieke H. Peters et al.   PLoS One

2 integrins separate graft-versus-host disease and graft-versus-leukemia effects

(2007) Y. Liang et al.   BLOOD

Sustained Remissions of High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome After Reduced-Intensity Conditioning Allogeneic Hematopoietic Transplantation: Chronic Graft-Versus-Host Disease Is the Strongest Factor Improving Survival

(2007) David Valcárcel et al.   JOURNAL OF CLINICAL ONCOLOGY