Article
Biochemistry & Molecular Biology
Priyadarshini Kachroo, Isobel D. Stewart, Rachel S. Kelly, Meryl Stav, Kevin Mendez, Amber Dahlin, Djora I. Soeteman, Su H. Chu, Mengna Huang, Margaret Cote, Hanna M. Knilhtila, Kathleen Lee-Sarwar, Michael McGeachie, Alberta Wang, Ann Chen Wu, Yamini Virkud, Pei Zhang, Nicholas J. Wareham, Elizabeth W. Karlson, Craig E. Wheelock, Clary Clish, Scott T. Weiss, Claudia Langenberg, Jessica A. Lasky-Su
Summary: The application of large-scale metabolomic profiling provides new opportunities for omics-based precision medicine in treating asthma. This study identifies and replicates 17 steroid metabolites that are significantly reduced in individuals with asthma, especially those receiving inhaled corticosteroid (ICS) treatment. The dose-dependent effect of ICS treatment on steroid levels suggests the need for regular cortisol monitoring to minimize the adverse effects of adrenal suppression. The findings highlight the importance of considering the public health implications of adrenal suppression in asthma patients receiving ICS treatment.
Review
Gastroenterology & Hepatology
Brigida Barberio, Ilaria Marsilio, Andrea Buda, Luisa Bertin, Gianluca Semprucci, Annalisa Zanini, Martina Crepaldi, Fabiana Zingone, Edoardo Savarino
Summary: This systematic review and meta-analysis evaluated the efficacy and safety of low bioavailability steroids in treating patients with mild-to-moderate ulcerative colitis. The results showed that low bioavailability steroids were more effective than placebo in achieving remission and had similar efficacy to 5-aminosalicylic acid (5-ASAs). More randomized controlled trials are needed to confirm these findings.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Allergy
Desiree Larenas-Linnemann, Jonathan Romeo, Barbara Ariue, John Oppenheimer
Summary: The study explores the preferred treatment and perceived hurdles among American College of Allergy, Asthma and Immunology members, finding variations in asthma therapy and underutilization of recommended treatments. The lack of insurance coverage is identified as a major obstacle.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Environmental Sciences
Linqi Gu, Shaohong Peng, Jieyu Zhang, Xingfan Lu, Caihong Xia, Jie Yu, Liwei Sun
Summary: In this study, the immune response in zebrafish eleutheroembryo was effectively activated by acupuncture, showing significant increases in transcription and protein levels of most immune genes. Additionally, exposure to an immunosuppressor further demonstrated the model's sensitivity in assessing the immunotoxicity of environmental pollutants. Therefore, the established immune model of zebrafish holds promise due to its sensitivity, safety, and simplicity in operation compared to existing methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, General & Internal
Ibrahim Bukhari, Muhammad Ashfaq, Bader-U-Nisa, Aijaz Ahmed, Hira Waseem, Mehrunnisa Yasir
Summary: The study compared the mean change in peak expiratory flow values in children with mild persistent asthma receiving inhaled beclomethasone dipropionate versus inhaled budesonide, and found that budesonide had slightly better efficacy compared to beclomethasone dipropionate.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Luca Casula, Chiara Sinico, Donatella Valenti, Elena Pini, Rosa Pireddu, Michele Schlich, Francesco Lai, Anna Maria Fadda
Summary: This study confirmed the ability of electronic nicotine delivery systems (ENDS) to deliver drug nanocrystals through aerosol production, suggesting their potential alternative use as medical devices for poorly soluble drugs delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Medicine, General & Internal
Kayleigh M. Kew, Ella Flemyng, Bradley S. Quon, Clarus Leung
Summary: This article compares the clinical effectiveness and safety of increased versus stable doses of inhaled corticosteroids (ICS) for home management of asthma exacerbations. The results suggest that increasing the dose does not have a significant impact on reducing the need for oral steroids, but other clinically important benefits and potential harms cannot be ruled out due to limitations in the trials.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Endocrinology & Metabolism
Kay Choong See
Summary: Inhaled corticosteroids (ICS) and intranasal corticosteroids (INS) are commonly used to treat chronic respiratory diseases. While they are generally considered to have fewer systemic side effects compared to oral corticosteroids, their impact on diabetes mellitus (DM) remains controversial. Multiple studies have shown that high doses of ICS are associated with increased incidence and worsened control of DM. Two studies also found a short-term association between INS use and hyperglycemia. More research is needed to evaluate the risk of DM-related adverse events with ICS/INS use, but high doses of ICS/INS should be avoided if possible.
WORLD JOURNAL OF DIABETES
(2023)
Article
Biochemistry & Molecular Biology
Yuli Qian, Philip W. Melchert, John S. Markowitz
Summary: This study investigated the pulmonary metabolism of beclomethasone dipropionate (BDP) and evaluated its interaction potential with cannabis compounds. The major active metabolite of BDP was found to be beclomethasone-17-monopropionate (17-BMP), and arylacetamide deacetylase might be the main enzyme involved. Both THC and CBD inhibited the hydrolysis of BDP in a reversible manner.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Respiratory System
Paul M. O'Byrne, Helen K. Reddel, Richard Beasley
Summary: ICS-containing reliever medication is superior to SABA as reliever alone and equivalent to maintenance ICS and SABA as reliever, particularly in reducing risks of severe asthma exacerbations, in studies comparing these reliever options.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Medicine, General & Internal
Antonio Moffa, Lucrezia Giorgi, Luca Carnuccio, Rodolfo Lugo, Peter Baptista, Manuele Casale
Summary: This study aimed to compare the efficacy of Beclomethasone Dipropionate (BDP) delivered via Spray-sol with nasal spray in allergic rhinitis (AR) patients. The results showed that BDP delivered with Spray-sol was more effective in reducing nasal symptoms and inflammation compared to nasal spray. These findings suggest the potential application of BDP nasal solution in the treatment of AR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Achuthan Aruljothy, Siddharth Singh, Neeraj Narula, Gordon W. Moran, Sudheer K. Vuyyuru, Malcolm Hogan, Alexa Zayadi, John K. MacDonald, Benedicte Caron, Silvio Danese, Laurent Peyrin Biroulet, Christopher Ma, Vipul Jairath
Summary: This study assessed the efficacy of medical treatments for ulcerative proctitis (UP). The results showed that topical application of 5-aminosalicylic acid and corticosteroids were effective for active UP. They may also be effective for maintenance of remission. Tacrolimus may be effective for induction of remission.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Allergy
Corine Rollema, Eric N. van Roon, Job F. M. van Boven, Paul Hagedoorn, Titia Klemmeier, Janwillem H. Kocks, Esther Metting, Hanneke N. G. Oude Elberink, Thomas T. A. Peters, Michel R. M. San Giorgi, Tjalling W. de Vries
Summary: This review provides an overview of the available literature on intranasal corticosteroids (INCs) for the treatment of allergic rhinitis (AR), emphasizing their efficacy and safety for moderate-to-severe AR. While local adverse events are common, INCs are generally considered to be safe and effective for short-term use. However, there is a lack of long-term safety data and knowledge regarding the risks of eye complications, hypothalamic-pituitary-adrenal axis suppression, and effects on bone and growth.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Pharmacology & Pharmacy
Luca Casula, Francesco Lai, Elena Pini, Donatella Valenti, Chiara Sinico, Maria Cristina Cardia, Salvatore Marceddu, Giorgia Ailuno, Anna Maria Fadda
Summary: Curcumin, when formulated as nanosuspensions, shows potential as an effective component in asthma treatment. The optimized Curcumin nanosuspension exhibited improved stability and solubility, while the multicomponent formulation also showed good stability and particle size distribution over 90 days. Nebulization tests of the samples demonstrated optimal aerodynamic parameters and mass median aerodynamic diameter below 5 μm.
Article
Medicine, General & Internal
Koshi Akahane, Atsushi Watanabe, Shinpei Somazu, Daisuke Harama, Tamao Shinohara, Shin Kasai, Hiroko Oshiro, Kumiko Goi, Norio Hasuda, Chihiro Ozawa, Kanji Sugita, Takeshi Inukai
Summary: Oral BDP therapy is an effective approach for GI tract GVHD that is resistant to standard immunosuppressive therapies.
Meeting Abstract
Hematology
Lakshminarayanan Nandagopal, Christine Ye, Marie Ventimiglia, Muneer H. Abidi, Lois Jeanne Ayash, Jeffrey Zonder, Lawrence Lum, Joseph Uberti, Voravit Ratanatharathorn, Divaya Bhutani, Abhinav Deol
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Meeting Abstract
Hematology
Lakshminarayanan Nandagopal, Christine Ye, Muneer H. Abidi, Lois Jeanne Ayash, Richard Manasa, Lawrence Lum, Joseph Uberti, Voravit Ratanatharathorn, Jeffrey Zonder, Divaya Bhutani, Abhinav Deol
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Article
Hematology
Bronwen E. Shaw, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Tanya L. Pedersen, Hisham Abdel-Azim, Muneer H. Abidi, Gorgun Akpek, Miguel A. Diaz, Andrew S. Artz, Christopher Dandoy, James L. Gajewski, Peiman Hematti, Rammurti T. Kamble, Kimberley A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Navneet S. Majhail, Paul V. O'Donne, Richard F. Olsson, Bipin N. Savani, Raquel M. Schears, David F. Stroncek, Galen E. Switzer, Eric P. Williams, John R. Wingard, Baldeep M. Wirk, Dennis L. Confer, Michael A. Pulsipher
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Meeting Abstract
Hematology
Craig H. Moskowitz, Auayporn Nadamanee, Tamas Masszi, Edward Agura, Jerzy Holowiecki, Muneer H. Abidi, Andy Chen, Patrick J. Stiff, Alessandro M. Gianni, Angelo M. Carella, Dzhelil Osmanov, Veronika Bachanova, John Sweetenham, Anna Sureda, Dirk Huebner, Emily K. Larsen, Naomi N. H. Hunder, Jan Walewski
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Article
Hematology
Divaya Bhutani, Gregory Dyson, Richard Manasa, Abhinav Deol, Voravit Ratanatharathorn, Lois Ayash, Muneer Abidi, Lawrence G. Lum, Zaid Al-Kadhimi, Joseph P. Uberti
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Article
Hematology
Ravi Vij, Shaji Kumar, Mei-Jie Zhang, Xiaobo Zhong, Jiaxing Huang, Angela Dispenzieri, Muneer H. Abidi, Jennifer M. Bird, Cesar O. Freytes, Robert Peter Gale, Tamila L. Kindwall-Keller, Robert A. Kyle, Daniel J. Landsburg, Hillard M. Lazarus, Reinhold Munker, Vivek Roy, Manish Sharma, Dan T. Vogl, Baldeep Wirk, Parameswaran N. Hari
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Article
Hematology
Nina Shah, Natalie Callander, Siddhartha Ganguly, Zartash Gul, Mehdi Hamadani, Luciano Costa, Salyka Sengsayadeth, Muneer Abidi, Parameswaran Hari, Mohamad Mohty, Yi-Bin Chen, John Koreth, Heather Landau, Hillard Lazarus, Helen Leather, Navneet Majhail, Rajneesh Nath, Keren Osman, Miguel-Angel Perales, Jeffrey Schriber, Paul Shaughnessy, David Vesole, Ravi Vij, John Wingard, Sergio Giralt, Bipin N. Savani
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)
Article
Oncology
William A. Wood, Jennifer Le-Rademacher, Karen L. Syrjala, Heather Jim, Paul B. Jacobsen, Jennifer M. Knight, Muneer H. Abidi, John R. Wingard, Navneet S. Majhail, Nancy L. Geller, J. Douglas Rizzo, Mingwei Fei, Juan Wu, Mary M. Horowitz, Stephanie J. Lee
Article
Oncology
Muthu Veeraputhiran, Tania Jain, Abhinav Deol, Lois Ayash, Seongho Kim, Gregory Dyson, Divaya Bhutani, Lawrence G. Lum, Voravit Ratanatharathorn, Joseph P. Uberti, Muneer H. Abidi
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2015)
Article
Medicine, General & Internal
Craig H. Moskowitz, Auayporn Nademanee, Tamas Masszi, Edward Agura, Jerzy Holowiecki, Muneer H. Abidi, Andy I. Chen, Patrick Stiff, Alessandro M. Gianni, Angelo Carella, Dzhelil Osmanov, Veronika Bachanova, John Sweetenham, Anna Sureda, Dirk Huebner, Eric L. Sievers, Andy Chi, Emily K. Larsen, Naomi N. Hunder, Jan Walewski
Article
Hematology
Chloe Anthias, Bronwen E. Shaw, Deidre M. Kiefer, Jane L. Liesveld, Jean Yared, Rammurti T. Kamble, Anita D'Souza, Peiman Hematti, Matthew D. Seftel, Maxim Norkin, Zachariah DeFilipp, Kimberly A. Kasow, Muneer H. Abidi, Bipin N. Savani, Nirali N. Shah, Paolo Anderlini, Miguel A. Diaz, Adriana K. Malone, Joerg P. Halter, Hillard M. Lazarus, Brent R. Logan, Galen E. Switzer, Michael A. Pulsipher, Dennis L. Confer, Paul V. O'Donnell
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2016)
Article
Hematology
Lawrence G. Lum, Archana Thakur, Vidya Kondadasula, Zaid Al-Kadhimi, Abhinav Deol, Elyse N. Tomaszewski, Hiroshi Yano, Dana L. Schalk, Lois Ayash, Jeffrey A. Zonder, Joseph P. Uberti, Muneer H. Abidi, Voravit Ratanatharathorn
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2016)
Article
Hematology
Muthu Veeraputhiran, Tania Jain, Simon Cronin, Zaid Al-Kadhimi, Muneer H. Abidi, Lois Ayash, Kendra Mellert, Lawrence G. Lum, Voravit Ratanatharathorn, Joseph P. Uberti, Abhinav Deol
JOURNAL OF CLINICAL APHERESIS
(2014)
Article
Oncology
Sikander Ailawadhi, Rachael Sexton, Suzanne Lentzsch, Muneer H. Abidi, Peter M. Voorhees, Adam D. Cohen, Eric M. Rohren, Stephen Heitner, Kevin Kelly, Niklas J. Mackler, David M. Baer, Antje Hoering, Brian Durie, Robert Z. Orlowski
CLINICAL CANCER RESEARCH
(2020)
Meeting Abstract
Hematology
Tania Jain, Maria Diab, Reda Awali, Joseph Uberti, Voravit Ratanatharathorn, Lois Jeanne Ayash, Abhinav Deol, Divaya Bhutani, Muneer H. Abidi
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2015)