Future pharmacological treatments for substance use disorders

A Double-Blind Randomized Controlled Trial ofN-Acetylcysteine in Cannabis-Dependent Adolescents

(2012) Kevin M. Gray et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effectiveness and Safety of Baclofen in the Treatment of Alcohol Dependent Patients

(2012) Lorenzo Leggio et al.   CNS & Neurological Disorders-Drug Targets

Nicotine Vaccines to Assist with Smoking Cessation

(2012) Tobias Raupach et al.   DRUGS

Pharmacokinetic strategies for treatment of drug overdose and addiction

(2012) David A Gorelick   Future Medicinal Chemistry

Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings

(2012) Helen C Fox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Cognitive enhancement as a treatment for drug addictions

(2012) Mehmet Sofuoglu et al.   NEUROPHARMACOLOGY

Pharmacogenetics of alcohol, nicotine and drug addiction treatments

(2011) Jessica E. Sturgess et al.   ADDICTION BIOLOGY

The GABA-B positive modulator GS39783 decreases psychostimulant conditioned-reinforcement and conditioned-reward

(2011) Briac Halbout et al.   ADDICTION BIOLOGY

YQA14: a novel dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, but not in D3 receptor-knockout mice

(2011) Rui Song et al.   ADDICTION BIOLOGY

Orexin A expression and promoter methylation in patients with alcohol dependence comparing acute and protracted withdrawal

(2011) Kristina Bayerlein et al.   ALCOHOL

Dose-Response Effect of Baclofen in Reducing Daily Alcohol Intake in Alcohol Dependence: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial

(2011) G. Addolorato et al.   ALCOHOL AND ALCOHOLISM

Prazosin Effects on Stress- and Cue-Induced Craving and Stress Response in Alcohol-Dependent Individuals: Preliminary Findings

(2011) Helen C. Fox et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Effects of Adrenal Sensitivity, Stress- and Cue-Induced Craving, and Anxiety on Subsequent Alcohol Relapse and Treatment Outcomes

(2011) Rajita Sinha   ARCHIVES OF GENERAL PSYCHIATRY

Translational research in addiction: Toward a framework for the development of novel therapeutics

(2011) Neil E. Paterson   BIOCHEMICAL PHARMACOLOGY

Activation of p38 signaling in the microglia in the nucleus accumbens contributes to the acquisition and maintenance of morphine-induced conditioned place preference

(2011) Xue-Qin Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Vaccines Against Drug Abuse

(2011) X Y Shen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Immunogenicity and Smoking-Cessation Outcomes for a Novel Nicotine Immunotherapeutic

(2011) D K Hatsukami et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Results of an initial clinical trial of varenicline for the treatment of cocaine dependence

(2011) Jennifer G. Plebani et al.   DRUG AND ALCOHOL DEPENDENCE

Modafinil for the treatment of methamphetamine dependence

(2011) Ann L. Anderson et al.   DRUG AND ALCOHOL DEPENDENCE

Galantamine improves sustained attention in chronic cocaine users.

(2011) Mehmet Sofuoglu et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence

(2011) Christoph von der Goltz et al.   HORMONES AND BEHAVIOR

A Vaccine Strategy that Induces Protective Immunity against Heroin

(2011) G. Neil Stowe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic N-Acetylcysteine during Abstinence or Extinction after Cocaine Self-Administration Produces Enduring Reductions in Drug Seeking

(2011) C. M. Reichel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

New medications for drug addiction hiding in glutamatergic neuroplasticity

(2011) P W Kalivas et al.   MOLECULAR PSYCHIATRY

Is Cognitive Functioning Impaired in Methamphetamine Users? A Critical Review

(2011) Carl L Hart et al.   NEUROPSYCHOPHARMACOLOGY

Chronic N-acetylcysteine after cocaine self-administration produces enduring reductions in drug-seeking

(2011) Carmela M Reichel et al.   NEUROPSYCHOPHARMACOLOGY

Cognitive enhancers in the treatment of substance use disorders: Clinical evidence

(2011) Kathleen T. Brady et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Immunopharmacotherapeutic manifolds and modulation of cocaine overdose

(2011) Jennifer B. Treweek et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Glutamatergic medications for the treatment of drug and behavioral addictions

(2011) M. Foster Olive et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals

(2011) María José Fernández-Serrano et al.   PSYCHOPHARMACOLOGY

Efficacy and Safety of Baclofen for Alcohol Dependence: A Randomized, Double-Blind, Placebo-Controlled Trial

(2010) James C. Garbutt et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cocaine-induced neuroadaptations in glutamate transmission

(2010) Heath D. Schmidt et al.   Annals of the New York Academy of Sciences

Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies

(2010) David V. Herin et al.   Annals of the New York Academy of Sciences

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders

(2010) Christian A. Heidbreder et al.   Annals of the New York Academy of Sciences

Dopamine signals for reward value and risk: basic and recent data

(2010) Wolfram Schultz   Behavioral and Brain Functions

Administration of GABAB receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference

(2010) Robin M. Voigt et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of the mGlu2/3 Agonist LY379268 and the mGlu5 Antagonist MTEP on Ethanol Seeking and Reinforcement Are Differentially Altered in Rats with a History of Ethanol Dependence

(2010) Nimish Sidhpura et al.   BIOLOGICAL PSYCHIATRY

Anti-(+)-Methamphetamine Monoclonal Antibody Antagonists Designed to Prevent the Progression of Human Diseases of Addiction

(2010) W B Gentry et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Breaking Barriers in the Genomics and Pharmacogenetics of Drug Addiction

(2010) M K Ho et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period

(2010) Adam Bisaga et al.   DRUG AND ALCOHOL DEPENDENCE

Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients

(2010) Alison Oliveto et al.   DRUG AND ALCOHOL DEPENDENCE

Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction

(2010) M. Foster Olive   EUROPEAN JOURNAL OF PHARMACOLOGY

Vaccines against morphine/heroine and its use as effective medication for preventing relapse to opiate addictive behaviors

(2010) Benito Anton et al.   Human vaccines & immunotherapeutics

Reduced neural response to reward following 7 days treatment with the cannabinoid CB1 antagonist rimonabant in healthy volunteers

(2010) Jamie Horder et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys

(2010) C. Achat-Mendes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In vivo characterization of the opioid antagonist nalmefene in mice

(2010) Melissa D. Osborn et al.   LIFE SCIENCES

Effects of Corticotropin-Releasing Factor Receptor-1 Antagonists on the Brain Stress System Responses to Morphine Withdrawal

(2010) J. Navarro-Zaragoza et al.   MOLECULAR PHARMACOLOGY

Disulfiram Attenuates Drug-Primed Reinstatement of Cocaine Seeking via Inhibition of Dopamine β-Hydroxylase

(2010) Jason P Schroeder et al.   NEUROPSYCHOPHARMACOLOGY

Repeated N-Acetyl Cysteine Reduces Cocaine Seeking in Rodents and Craving in Cocaine-Dependent Humans

(2010) Shelley L Amen et al.   NEUROPSYCHOPHARMACOLOGY

Reconsidering anhedonia in depression: Lessons from translational neuroscience

(2010) Michael T. Treadway et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse

(2010) K. Moussawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans

(2010) Mehmet Sofuoglu et al.   PSYCHOPHARMACOLOGY

Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats

(2010) Styliani Vlachou et al.   PSYCHOPHARMACOLOGY

Chronic Cigarette Smoking: Implications for Neurocognition and Brain Neurobiology

(2010) Timothy C. Durazzo et al.   International Journal of Environmental Research and Public Health

A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence

(2009) James Shearer et al.   ADDICTION

Cognitive enhancement as a pharmacotherapy target for stimulant addiction

(2009) Mehmet Sofuoglu   ADDICTION

Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence

(2009) Marie Longo et al.   ADDICTION

Role of the GABAB receptor in alcohol-seeking and drinking behavior

(2009) Paola Maccioni et al.   ALCOHOL

A Pilot Trial of the Alpha-1 Adrenergic Antagonist, Prazosin, for Alcohol Dependence

(2009) Tracy L. Simpson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Randomized, Double-Blind, Placebo-Controlled Trial of Vigabatrin for the Treatment of Cocaine Dependence in Mexican Parolees

(2009) Jonathan D. Brodie et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Role for mGluR5 Receptors in Intravenous Methamphetamine Self-Administration

(2009) Megan P. H. Osborne et al.   Annals of the New York Academy of Sciences

Chronic Stress, Drug Use, and Vulnerability to Addiction

(2009) Rajita Sinha   Annals of the New York Academy of Sciences

The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation

(2009) T.W. Robbins et al.   Annual Review of Neuroscience

Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients

(2009) Bridget A. Martell et al.   ARCHIVES OF GENERAL PSYCHIATRY

Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers

(2009) Sherry A. McKee et al.   BIOLOGICAL PSYCHIATRY

Role of orexin/hypocretin in dependence and addiction

(2009) Ruth Sharf et al.   BRAIN RESEARCH

Pharmacotherapy of Addictive Disorders

(2009) Stephen Ross et al.   CLINICAL NEUROPHARMACOLOGY

Cholinergic Functioning in Stimulant Addiction

(2009) Mehmet Sofuoglu et al.   CNS DRUGS

Antibodies for Therapeutic Uses and the Evolution of Biotechniques

(2009) P. Nieri et al.   CURRENT MEDICINAL CHEMISTRY

Dissecting components of reward: ‘liking’, ‘wanting’, and learning

(2009) Kent C Berridge et al.   CURRENT OPINION IN PHARMACOLOGY

Effects of cocaine esterase following its repeated administration with cocaine in mice

(2009) Mei-Chuan Ko et al.   DRUG AND ALCOHOL DEPENDENCE

Multi-center trial of baclofen for abstinence initiation in severe cocaine-dependent individuals

(2009) Roberta Kahn et al.   DRUG AND ALCOHOL DEPENDENCE

Modafinil for the treatment of cocaine dependence

(2009) Ann L. Anderson et al.   DRUG AND ALCOHOL DEPENDENCE

Spending on new drug development

(2009) Christopher Paul Adams et al.   HEALTH ECONOMICS

Progesterone attenuates cocaine-induced responses

(2009) Vanya Quinones-Jenab et al.   HORMONES AND BEHAVIOR

Is the inhibition of nicotinic acetylcholine receptors by bupropion involved in its clinical actions?

(2009) Hugo R. Arias   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain

(2009) Nora D. Volkow et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Addiction Genetics and Pleiotropic Effects of Common Haplotypes that Make Polygenic Contributions to Vulnerability to Substance Dependence

(2009) George R. Uhl et al.   JOURNAL OF NEUROGENETICS

Cocaine Esterase Prevents Cocaine-Induced Toxicity and the Ongoing Intravenous Self-Administration of Cocaine in Rats

(2009) G. T. Collins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse

(2009) DR Jasinski et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Heterogeneity of Reward Mechanisms

(2009) A. Lajtha et al.   NEUROCHEMICAL RESEARCH

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Drug Abuse: Vulnerability and Transition to Addiction

(2009) M. Le Moal   PHARMACOPSYCHIATRY

Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans

(2009) Mehmet Sofuoglu et al.   PSYCHOPHARMACOLOGY

Dopamine receptors in the learning, memory and drug reward circuitry

(2009) Jeffrey W. Dalley et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Provigil (Modafinil) Plus Cognitive Behavioral Therapy for Methamphetamine Use in HIV+ Gay Men: A Pilot Study

(2009) Martin C. McElhiney et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

α1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol

(2008) Brendan M. Walker et al.   ALCOHOL

The α1-Adrenergic Receptor Antagonist, Prazosin, Reduces Alcohol Drinking in Alcohol-Preferring (P) Rats

(2008) Dennis D. Rasmussen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

An Evaluation of μ-Opioid Receptor (OPRM1) as a Predictor of Naltrexone Response in the Treatment of Alcohol Dependence

(2008) Raymond F. Anton et al.   ARCHIVES OF GENERAL PSYCHIATRY

Orexin Mediates the Expression of Precipitated Morphine Withdrawal and Concurrent Activation of the Nucleus Accumbens Shell

(2008) Ruth Sharf et al.   BIOLOGICAL PSYCHIATRY

The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans

(2008) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Varenicline Improves Mood and Cognition During Smoking Abstinence

(2008) Freda Patterson et al.   BIOLOGICAL PSYCHIATRY

Atomoxetine Modulates Right Inferior Frontal Activation During Inhibitory Control: A Pharmacological Functional Magnetic Resonance Imaging Study

(2008) Samuel R. Chamberlain et al.   BIOLOGICAL PSYCHIATRY

Randomized, placebo-controlled trial of bupropion for the treatment of methamphetamine dependence

(2008) Steven Shoptaw et al.   DRUG AND ALCOHOL DEPENDENCE

The Case for Chronic Disease Management for Addiction

(2008) Richard Saitz et al.   Journal of Addiction Medicine

The Effect of a Chimeric Human/Murine Anti-Cocaine Monoclonal Antibody on Cocaine Self-Administration in Rats

(2008) A. B. Norman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Positive Modulation of GABAB Receptors Decreased Nicotine Self-Administration and Counteracted Nicotine-Induced Enhancement of Brain Reward Function in Rats

(2008) N. E. Paterson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers

(2008) DR Jasinski et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats

(2008) Xiao-Qing Peng et al.   NEUROPHARMACOLOGY

Role of lateral hypothalamic orexin neurons in reward processing and addiction

(2008) Gary Aston-Jones et al.   NEUROPHARMACOLOGY

Glutamate transmission in addiction

(2008) Peter W. Kalivas et al.   NEUROPHARMACOLOGY

mGluR5 Antagonism Attenuates Methamphetamine Reinforcement and Prevents Reinstatement of Methamphetamine-Seeking Behavior in Rats

(2008) Justin T Gass et al.   NEUROPSYCHOPHARMACOLOGY

Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: A validation study

(2008) Robert A. Schnoll et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration

(2008) Thomas N. Greenwell et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction

(2008) B. J Everitt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Insular hypocretin transmission regulates nicotine reward

(2008) J. A. Hollander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of cocaine-seeking by progesterone treatment in female rats

(2008) Matthew W. Feltenstein et al.   PSYCHONEUROENDOCRINOLOGY

Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats

(2008) J. David Jentsch et al.   PSYCHOPHARMACOLOGY

Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys

(2008) Emanuele Seu et al.   PSYCHOPHARMACOLOGY

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats

(2008) Jemma K. Richards et al.   PSYCHOPHARMACOLOGY

A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence

(2007) Helen M. Pettinati et al.   ADDICTIVE BEHAVIORS

Addiction and the Brain Antireward System

(2007) George F. Koob et al.   Annual Review of Psychology

N-Acetylcysteine Reduces Extinction Responding and Induces Enduring Reductions in Cue- and Heroin-Induced Drug-Seeking

(2007) Wenhua Zhou et al.   BIOLOGICAL PSYCHIATRY

Progesterone attenuates cocaine-induced conditioned place preference in female rats

(2007) Scott J. Russo et al.   BRAIN RESEARCH

Sex differences in drug abuse

(2007) Jill B. Becker et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The orexin system regulates alcohol-seeking in rats

(2006) Andrew J Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY