Pharmacokinetic strategies for treatment of drug overdose and addiction

Immunogenicity and Smoking-Cessation Outcomes for a Novel Nicotine Immunotherapeutic

(2011) D K Hatsukami et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ethical and policy issues in using vaccines to treat and prevent cocaine and nicotine dependence

(2011) Wayne Hall et al.   CURRENT OPINION IN PSYCHIATRY

Prolonged Toxic Effects After Cocaine Challenge in Butyrylcholinesterase/Plasma Carboxylesterase Double Knockout Mice: A Model for Butyrylcholinesterase-Deficient Humans

(2011) E. G. Duysen et al.   DRUG METABOLISM AND DISPOSITION

Combined active and passive immunization against nicotine: Minimizing monoclonal antibody requirements using a target antibody concentration strategy

(2011) Katherine E. Cornish et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Vaccine Strategy that Induces Protective Immunity against Heroin

(2011) G. Neil Stowe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines

(2011) F. Ivy Carroll et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impact of Distinct Chemical Structures for the Development of a Methamphetamine Vaccine

(2011) Amira Y. Moreno et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cocaine Analog Coupled to Disrupted Adenovirus: A Vaccine Strategy to Evoke High-titer Immunity Against Addictive Drugs

(2011) Martin J Hicks et al.   MOLECULAR THERAPY

Amelioration of the Cardiovascular Effects of Cocaine in Rhesus Monkeys by a Long-Acting Mutant Form of Cocaine Esterase

(2011) Gregory T Collins et al.   NEUROPSYCHOPHARMACOLOGY

Computational design of a thermostable mutant of cocaine esterase via molecular dynamics simulations

(2011) Xiaoqin Huang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Drug Wanting: Behavioral Sensitization and Relapse to Drug-Seeking Behavior

(2011) J. D. Steketee et al.   PHARMACOLOGICAL REVIEWS

Immunopharmacotherapeutic manifolds and modulation of cocaine overdose

(2011) Jennifer B. Treweek et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Treatment of nicotine addiction: present therapeutic options and pipeline developments

(2011) Riccardo Polosa et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting nicotine addiction: the possibility of a therapeutic vaccine

(2011) Jose Escobar-Chavez   Drug Design Development and Therapy

In silico experiments of single-chain antibody fragment against drugs of abuse

(2010) Guodong Hu et al.   BIOPHYSICAL CHEMISTRY

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin

(2010) MJ Hatfield et al.   BRITISH JOURNAL OF PHARMACOLOGY

The concept of pharmacologic cocaine interception as a treatment for drug abuse

(2010) Yang Gao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

High-level expression of functional recombinant human butyrylcholinesterase in silkworm larvae by Bac-to-Bac system

(2010) Shuo Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Anti-(+)-Methamphetamine Monoclonal Antibody Antagonists Designed to Prevent the Progression of Human Diseases of Addiction

(2010) W B Gentry et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Vaccines against morphine/heroine and its use as effective medication for preventing relapse to opiate addictive behaviors

(2010) Benito Anton et al.   Human vaccines & immunotherapeutics

Development of active and passive human vaccines to treat methamphetamine addiction

(2010) W. Brooks Gentry et al.   Human vaccines & immunotherapeutics

A Critical Evaluation of a Nicotine Vaccine within a Self-Administration Behavioral Model

(2010) Amira Y. Moreno et al.   MOLECULAR PHARMACEUTICS

Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine

(2010) L. Xue et al.   MOLECULAR PHARMACOLOGY

Effects of cocaine hydrolase on cocaine self-administration under a PR schedule and during extended access (escalation) in rats

(2010) Marilyn E. Carroll et al.   PSYCHOPHARMACOLOGY

Nicotine hapten structure, antibody selectivity and effect relationships: Results from a nicotine vaccine screening procedure

(2010) Sabina H.L. de Villiers et al.   VACCINE

Cocaine Vaccine for the Treatment of Cocaine Dependence in Methadone-Maintained Patients

(2009) Bridget A. Martell et al.   ARCHIVES OF GENERAL PSYCHIATRY

Cocaine-Specific Antibodies Blunt the Subjective Effects of Smoked Cocaine in Humans

(2009) Margaret Haney et al.   BIOLOGICAL PSYCHIATRY

Antibodies for Therapeutic Uses and the Evolution of Biotechniques

(2009) P. Nieri et al.   CURRENT MEDICINAL CHEMISTRY

Effects of cocaine esterase following its repeated administration with cocaine in mice

(2009) Mei-Chuan Ko et al.   DRUG AND ALCOHOL DEPENDENCE

Drug users’ adherence to a 6-month vaccination protocol: Effects of motivational incentives

(2009) Maxine L. Stitzer et al.   DRUG AND ALCOHOL DEPENDENCE

Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats

(2009) Susan K. Wood et al.   DRUG AND ALCOHOL DEPENDENCE

Anti-drug vaccines to treat substance abuse

(2009) Berma M Kinsey et al.   IMMUNOLOGY AND CELL BIOLOGY

PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity

(2009) Jun-Beom Park et al.   JOURNAL OF CONTROLLED RELEASE

Lasting Reduction of Cocaine Action in Neostriatum-- A Hydrolase Gene Therapy Approach

(2009) Y. Gao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cocaine Esterase Prevents Cocaine-Induced Toxicity and the Ongoing Intravenous Self-Administration of Cocaine in Rats

(2009) G. T. Collins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Immunopharmacotherapy: Vaccination strategies as a treatment for drug abuse and dependence

(2009) Amira Y. Moreno et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine

(2009) Reha Celikel et al.   PROTEIN SCIENCE

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines

(2009) Michael J. Duryee et al.   VACCINE

A Bacterial Cocaine Esterase Protects Against Cocaine-Induced Epileptogenic Activity and Lethality

(2008) Emily M. Jutkiewicz et al.   ANNALS OF EMERGENCY MEDICINE

Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo

(2008) Nageswararao Chilukuri et al.   CHEMICO-BIOLOGICAL INTERACTIONS

An albumin–butyrylcholinesterase for cocaine toxicity and addiction: Catalytic and pharmacokinetic properties

(2008) Yang Gao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Prevention of Drug-Induced Memory Impairment by Immunopharmacotherapy

(2008) Jennifer B. Treweek et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Effect of a Chimeric Human/Murine Anti-Cocaine Monoclonal Antibody on Cocaine Self-Administration in Rats

(2008) A. B. Norman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cotinine Selectively Activates a Subpopulation of  3/ 6 2 Nicotinic Receptors in Monkey Striatum

(2008) K. O'Leary et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Desensitization of Nicotinic Acetylcholine Receptors as a Strategy for Drug Development

(2008) J. J. Buccafusco et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Thermostable Variants of Cocaine Esterase for Long-Time Protection against Cocaine Toxicity

(2008) D. Gao et al.   MOLECULAR PHARMACOLOGY

Human Recombinant Butyrylcholinesterase Purified from the Milk of Transgenic Goats Interacts with Beta-Amyloid Fibrils and Suppresses Their Formation in vitro

(2008) E. Podoly et al.   Neurodegenerative Diseases

A Cocaine Hydrolase Engineered from Human Butyrylcholinesterase Selectively Blocks Cocaine Toxicity and Reinstatement of Drug Seeking in Rats

(2008) Stephen Brimijoin et al.   NEUROPSYCHOPHARMACOLOGY

A Vaccine against Nicotine for Smoking Cessation: A Randomized Controlled Trial

(2008) Jacques Cornuz et al.   PLoS One

Pharmacokinetic approaches to treatment of drug addiction

(2008) David A Gorelick   Expert Review of Clinical Pharmacology

Structure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction

(2007) Fang Zheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY