Article
Endocrinology & Metabolism
Omprakash Singh, Devraj Singh, Saptarsi Mitra, Anal Kumar, Ronald M. Lechan, Praful S. Singru
Summary: Compared to mammals, birds have a higher metabolic rate and are involved in energy-demanding activities. However, the mechanisms of energy regulation in birds are not well understood. This study focuses on the interaction between neuropeptide Y (NPY) and thyrotropin-releasing hormone (TRH) in modulating energy balance in zebra finches. The results show that fasting reduces body weight and TRH levels, but increases NPY levels in certain brain regions of the finches. Refeeding restores TRH levels to normal, suggesting the role of NPY in regulating energy balance in birds.
Article
Endocrinology & Metabolism
Frederick Wasinski, Franco Barrile, Joao A. B. Pedroso, Paula G. F. Quaresma, Willian O. dos Santos, Edward O. List, John J. Kopchick, Mario Perello, Jose Donato
Summary: The study demonstrates the essential role of GHR signaling in the brain for the orexigenic effect of ghrelin, independent of GH action on ARH (AgRP/NPY) neurons.
Article
Endocrinology & Metabolism
Frederick Wasinski, Franco Barrile, Joao A. B. Pedroso, Paula G. F. Quaresma, Willian O. dos Santos, Edward O. List, John J. Kopchick, Mario Perello, Jose Donato
Summary: The study indicates that the GHR signaling in the brain is necessary for the orexigenic effect of ghrelin, independent of the action of GH on ARH (AgRP/NPY) neurons.
Article
Nutrition & Dietetics
Ying Sun, Xin Du, Zhongyan Shan, Weiping Teng, Yaqiu Jiang
Summary: Excessive iodine intake leads to elevated TSH levels without affecting TT3 and TT4 levels. It also decreases TRH levels in the hypothalamus and increases the expression of Dio2 and MCT8 in the hypothalamus.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Virology
Arkom Chaiwongkot, Supranee Buranapraditkun, Shina Oranratanaphan, Thanaporn Chuen-Im, Nakarin Kitkumthorn
Summary: Cervical cancer screening typically involves a Pap smear combined with high-risk human papillomavirus (hr-HPV) detection. Bioinformatics analysis identified a methylation marker cg01009664, which can enhance the accuracy of detecting CIN2+. The real-time PCR assay demonstrates high sensitivity and specificity in identifying CIN2+ and can effectively aid in the diagnosis of cervical lesions.
Review
Endocrinology & Metabolism
Ivan Lazcano, Adair Rodriguez Rodriguez, Rosa Maria Uribe, Aurea Orozco, Patricia Joseph-Bravo, Jean-Louis Charli
Summary: Thyroid hormones are ancient signaling molecules that regulate metabolism and growth in vertebrates through the hypothalamus-pituitary-thyroid axis. The hypothalamic factors that induce TSH secretion vary among vertebrates, but all play a role in activating TH synthesis in the thyroid gland.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
H. E. Flay, C. B. Reed, B. Kuhn-Sherlock, C. V. C. Phyn, C. R. Burke, S. Meier, I. J. Clarke
Summary: Previous research has found that Holstein-Friesian dairy heifers with positive genetic merit for fertility traits reach puberty earlier than those with negative genetic merit. This study investigated the functionality of the hypothalamus-pituitary-gonadal (HPG) axis in peripubertal heifers with divergent genetic merit, finding that the earlier onset of puberty in positive heifers is associated with earlier activation of the HPG axis.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Endocrinology & Metabolism
Marco Antonio Parra-Montes De Oca, Israim Sotelo-Rivera, Angelica Gutierrez-Mata, Jean-Louis Charli, Patricia Joseph-Bravo
Summary: The hypothalamus-pituitary-thyroid-axis (HPT) is an important neuroendocrine axis that regulates energy expenditure, with its activity modulated by factors such as sex, nutritional status and stress. Sex differences may be influenced by sex steroid concentrations and sex chromosomes, impacting the expression of relevant genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Cristina Miralpeix, Ana Cristina Reguera, Anna Fosch, Sebastian Zagmutt, Nuria Casals, Daniela Cota, Rosalia Rodriguez-Rodriguez
Summary: The hypothalamus plays a crucial role in the pathogenesis of obesity, with disrupted endocannabinoid system considered a landmark indicator. Recent research has expanded knowledge of the complex endocannabinoid system, focusing on CB receptors, ligands, non-CB receptors, and metabolizing enzymes, particularly in the hypothalamus. The insights gained have provided promising targets for tackling obesity and related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eva Prida, Sara Alvarez-Delgado, Raquel Perez-Lois, Mateo Soto-Tielas, Ana Estany-Gestal, Johan Ferno, Luisa Maria Seoane, Mar Quinones, Omar Al-Massadi
Summary: Fibroblast growth factor 21 plays a key role in regulating metabolism and has direct effects on the central nervous system. It is involved in maintaining energy homeostasis, glucose and lipid metabolism, and insulin sensitivity. Recombinant fibroblast growth factor 21 therapies have shown efficacy in counteracting obesity and related metabolic disorders in rodents and nonhuman primates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai -Min Bao
Summary: Increased expression of OXT in PVN and OXTR in DLPFC are characteristic for male BD patients. Stimulation of PVN-OXT neurons induced mood changes in mice, in a pattern different from BD.
Article
Physiology
Wen-Ying Liu, Raina Ladha, Hattie Liu, Richard L. Horner
Summary: The study found that Taltirelin is a stable upper airway-preferring respiratory stimulant that increases muscle activity and arousal, while suppressing non-REM sleep. These traits have potential favorable relevance to some respiratory disorders.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Neurosciences
Hua Zhang, Jing-Jing Zhou, Jian-Ying Shao, Zhao-Fu Sheng, Jingxiong Wang, Peiru Zheng, Xunlei Kang, Zhenguo Liu, Zixi Jack Cheng, David D. Kline, De -Pei Li
Summary: Elevated levels of CRH and CRHR1 in the PVN are associated with increased sympathetic outflow in primary hypertension, potentially contributing to the hyperactivity of PVN presympathetic neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Daniela O. Gusmao, Maria E. de Sousa, Mariana R. Tavares, Jose Donato
Summary: This study demonstrates that GHRH neurons are a key and necessary site for the long-loop negative feedback that controls the GH/IGF-1 axis and body growth. GHRH(Delta IGF1R) mice exhibit higher body growth and GH levels.
Review
Cell Biology
Jose Donato, Frederick Wasinski, Isadora C. Furigo, Martin Metzger, Renata Frazao
Summary: Growth hormone plays a crucial role in regulating metabolism in the brain, affecting food intake, energy expenditure, blood sugar levels, and neuroendocrine changes. It acts as a hormonal factor that conveys homeostatic information to the brain to produce metabolic adjustments in order to promote energy homeostasis.
Article
Neurosciences
Brian E. Bernier, Anthony F. Lacagnina, Adam Ayoub, Francis Shue, Boris V. Zemelman, Franklin B. Krasne, Michael R. Drew
JOURNAL OF NEUROSCIENCE
(2017)
Article
Reproductive Biology
Chad D. Foradori, Laura R. Hinds, Alicia M. Quihuis, Anthony F. Lacagnina, Charles B. Breckenridge, Robert J. Handa
BIOLOGY OF REPRODUCTION
(2011)
Article
Endocrinology & Metabolism
Ryoko Hiroi, Anthony F. Lacagnina, Laura R. Hinds, David G. Carbone, Rosalie M. Uht, Robert J. Handa
Article
Psychology, Biological
David L. Carbone, Damian G. Zuloaga, Anthony F. Lacagnina, Robert F. McGivern, Robert J. Handa
PHYSIOLOGY & BEHAVIOR
(2012)
Article
Neurosciences
Anthony F. Lacagnina, Emma T. Brockway, Chelsea R. Crovetti, Francis Shue, Meredith J. McCarty, Kevin P. Sattler, Sean C. Lim, Sofia Leal Santos, Christine A. Denny, Michael R. Drew
NATURE NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Kirstie A. Cummings, Anthony F. Lacagnina, Roger L. Clem
Summary: Recent studies suggest that while excitatory projection neurons (PNs) play a critical role in memory functions, their activity during learning and recall is extensively regulated by a diverse array of GABAergic interneurons (INs). These findings highlight the importance of investigating the role of interneurons in fear memory networks.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Endocrinology & Metabolism
Chad D. Foradori, Jessica E. Healy, Arthur D. Zimmerman, Robert J. Kemppainen, Melaney A. Jones, Casey C. Read, B. Douglas White, Kun Don Yi, Laura R. Hinds, Anthony F. Lacagnina, Alicia M. Quihuis, Charles B. Breckenridge, Robert J. Handa
Article
Neurosciences
Brian E. Bernier, Anthony F. Lacagnina, Michael R. Drew
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.