Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Egor Y. Plotnikov, Egor A. Turovsky
Summary: A defect in brain blood circulation leads to ischemia, damage, and death of nerve cells. This study reveals the protective role of neuronal calcium sensor-1 (NCS-1) in ischemia/reoxygenation and hyperammonemia. Knockdown of NCS-1 increases cell death and exacerbates symptoms of network hyperexcitation, especially in GABAergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Jirayu Buatong, Ajay Mittal, Pimonsri Mittraparp-arthorn, Suriya Palamae, Jirakrit Saetang, Soottawat Benjakul
Summary: The antibacterial effect of chitooligosaccharide conjugated with five different polyphenols against Listeria monocytogenes was investigated. Among all the conjugates tested, COS-EGCG showed the highest inhibition toward Listeria monocytogenes, with a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 1024 μg/mL, respectively. The COS-EGCG conjugate also had a bactericidal effect on the environmental and clinical strains of L. monocytogenes.
Article
Immunology
Xiaoyan Ren, Jiangang Yu, Lili Guo, Hong Ma
Summary: The study showed that DPP3 plays a neuroprotective role in neurons injured by OGD/R by suppressing apoptosis, oxidative stress, and inflammation through modulation of the Keap1/Nrf2 signaling pathway. The findings suggest DPP3 as a potential target for providing neuroprotective effects during cerebral ischemia/reperfusion injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Wenbin Lan, Jianhua Lin, Weinan Liu, Fasheng Wang, Yun Xie
Summary: The study demonstrates that Srxn 1 plays a significant role in anti-apoptosis of spinal cord neurons, and may be a potential therapeutic target for spinal cord I/R injury.
NEUROSCIENCE LETTERS
(2021)
Article
Ophthalmology
Annette Zwanzig, Jie Meng, Heidi Mueller, Susanne Buerger, Manuela Schmidt, Maik Pankonin, Peter Wiedemann, Jan Darius Unterlauft, Wolfram Eichler
Summary: Secreted neuroprotective factors produced by Muller cells can promote RGC survival, and R28 cells are more resistant to apoptosis when co-cultured with Muller cells. Under hypoxia, IL-6 and VEGF are upregulated in Muller cells, and these factors can also alter the expression of Bcl-2 family members, which regulate apoptosis.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Neurosciences
Zhihong Wu, Changning Xie, Haixia Kuang, Jian Wu, Xiao Chen, Huibao Liu, Tao Liu
Summary: The study showed that oxytocin plays a critical role in attenuating neonatal neural death by facilitating GABAergic transmission, which may help regulate the excitatory-inhibitory balance in local neuronal networks in NHIE patients.
Article
Immunology
Ruili Wang, Lei Li, Baogong Wang
Summary: Poncirin protects cortical neurons from oxygen-glucose deprivation/reoxygenation injury by inhibiting the NOX4/ROS/NLRP3 axis. It alleviates neuronal damage caused by mitochondrial dysfunction, oxidative stress, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shixin Xu, Nannan Zhang, Lanlan Cao, Lu Liu, Hao Deng, Shengyu Hua, Yunsha Zhang
Summary: A network pharmacological analysis was used to investigate the neuroprotective mechanism of Tetramethylpyrazine (TMP). The study found that TMP attenuated OGD-induced cell injury and protected PC12 cells by inhibiting the HIF-1a/BNIP3 pathway. This provides new insights into the potential neuroprotective effects of TMP. Overall, the study is rated 9 out of 10 for its importance.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Neurosciences
Hefei Fu, Jiapeng Wang, Jie Wang, Langni Liu, Jianxiong Jiang, Jiukuan Hao
Summary: This study demonstrated that 4R-cembranoid promotes the protective M2 activation and inhibits the damaging M1 activation in microglial cells. The neuroprotective effects of 4R were shown through regulation of microglial activation, with decreased TNF-a release and increased IL-10 release. These findings suggest that 4R could be a promising lead structure for the development of drugs for the treatment of ischemic stroke and other neurodegenerative diseases with an inflammatory component involved.
BRAIN RESEARCH BULLETIN
(2022)
Article
Chemistry, Applied
Gun-Woo Oh, Se-Chang Kim, Tae-Hee Kim, Won-Kyo Jung
Summary: In this study, chitooligosaccharide (COS) and salicylic acid (SA) conjugates were synthesized and oxidized alginate (OA) and gelatin hydrogels were fabricated. Tests confirmed successful synthesis of COS-SA conjugates with improved antioxidant activity. The hydrogels showed non-cytotoxicity and wound healing activity, indicating their potential for wound healing applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Elena G. Varlamova, Nina I. Uspalenko, Natalia V. Khmil, Maria I. Shigaeva, Mikhail R. Stepanov, Mikhail A. Ananyan, Maria A. Timchenko, Maxim V. Molchanov, Galina D. Mironova, Egor A. Turovsky
Summary: Cerebral ischemia affects up to 15 million people worldwide every year, making the development of effective preventive programs and therapy methods crucial. This study compared the cytoprotective mechanisms of taxifolin (TAX) and its new water-soluble form, aqua taxifolin (aqTAX), on cultured brain cells under ischemic conditions. The results showed that aqTAX exhibited better protective effects by inhibiting cell death and reducing the increase in intracellular calcium levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jin Young Hong, Hyunseong Kim, Changhwan Yeo, Wan-Jin Jeon, Junseon Lee, Seung Ho Baek, Yoon Jae Lee, In-Hyuk Ha
Summary: Uwhangchungsimwon (UCW), a multi-component herbal product, effectively protects neurons from oxygen glucose deprivation/re-oxygenation (OGD/R) induced degeneration and cell death, possibly by activating VEGF-VEGFR and insulin-like growth factor 1 receptor expression.
Article
Multidisciplinary Sciences
Nicholas P. DeAdder, Hannah J. Gillam, Brian C. Wilson
Summary: The study showed that H2 and H3 relaxin treatments have a protective effect on cell death caused by oxygen and glucose deprivation, with the effect of H3 relaxin being partially attenuated by L-NIL, and antagonism of RXFP3 affecting the action of H3 relaxin.
Article
Neurosciences
Hye-Sun Lim, Gunhyuk Park
Summary: This study investigated the protective effects of resilin on Parkinson's disease (PD) and found that it inhibits the apoptosis of dopaminergic neurons by regulating apoptosis signals. The experimental results showed that resilin significantly reduced neurotoxicity and prevented dopamine depletion in PD models. Behavioral studies further confirmed the improvement of motor impairment in PD treated with resilin.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.