Article
Biology
Andrew T. Francis, Bryce Manifold, Elena C. Carlson, Ruoqian Hu, Andrew H. Hill, Shuaiqian Men, Dan Fu
Summary: This study presents the construction of a microscope that allows simultaneous nonlinear absorption, Raman, and fluorescence imaging. Machine learning is used to predict the identity of cells lining capillaries, which has significant implications for multiple research fields.
COMMUNICATIONS BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Evelyn Lara, Nathaly Rivera, Alejandro Gonzalez-Bernal, Daniela Rojas, Daniela Lopez-Espindola, Andres Rodriguez, Carlos Escudero
Summary: This study evaluated brain microvascular perfusion and microvascular reactivity in offspring born to mice with preeclampsia-like syndrome. It found that the offspring exhibited impaired brain perfusion and microvascular reactivity, particularly in female mice, associated with differential expression of angiogenic proteins in the brain tissue.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Adriana Knezic, Brad R. S. Broughton, Robert E. Widdop, Claudia A. McCarthy
Summary: This study examined the effect of different lengths of light exposure on photothrombotic stroke in two strains of mice. The results showed that increasing light exposure systematically increases infarct volume but does not worsen functional outcomes. Additionally, there were subtle differences in functional outcomes between the FVB/N and C57Bl/6 mice.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Emma Martinez-Alonso, Natalia Guerra-Perez, Alejandro Escobar-Peso, Lorena Peracho, Rocio Vera-Lechuga, Antonio Cruz-Culebras, Jaime Masjuan, Alberto Alcazar
Summary: This study investigates the role of protein translation regulation in ischemic stroke. The results demonstrate that the phosphorylation of eIF4G1 increases during ischemia-reperfusion, and it colocalizes with eIF4E in the vulnerable brain region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nawar Sakr, Olga Glazova, Liudmila Shevkova, Nikita Onyanov, Samira Kaziakhmedova, Alena Shilova, Maria V. Vorontsova, Pavel Volchkov
Summary: Tissue autofluorescence in fixed tissue sections is a major issue in fluorescence microscopy. The intense intrinsic fluorescence emitted by the adrenal cortex interferes with fluorescent labels, resulting in poor-quality images. Various tissue treatment methods were evaluated for reducing autofluorescence, and TrueBlack (TM) Lipofuscin Autofluorescence Quencher and MaxBlock (TM) Autofluorescence Reducing Reagent Kit were found to be the most effective, reducing autofluorescence intensity by 89-93% and 90-95%, respectively. These treatments preserved specific fluorescence signals and tissue integrity, allowing reliable detection of fluorescent labels in the adrenal cortex tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Kahlilia C. Morris-Blanco, Anil K. Chokkalla, Mario J. Bertogliat, Raghu Vemuganti
Summary: The study demonstrates that TET3 plays a role in ischemic neuroprotection by regulating the levels of 5hmC at gene promoter regions, modulating multiple neuroprotective pathways, and potentially improving outcomes following ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Zhensen Chen, Anders Gould, Duygu Baylam Geleri, Niranjan Balu, Li Chen, Baocheng Chu, Kristi Pimentel, Gador Canton, Thomas S. Hatsukami, Chun Yuan
Summary: The study aimed to explore the associations between intracranial vascular features extracted from NCE-MRA images and global cognition. The results showed that artery length and number of branches were positively associated with cognitive scores. These findings suggest that intracranial vascular features may serve as useful markers of cerebrovascular health and provide additional information in individuals with cognitive impairment.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Yan Mi, Kun Jiao, Ji-kai Xu, Kun Wei, Jing-yu Liu, Qing-qi Meng, Ting-ting Guo, Xue-ni Zhang, Di Zhou, De-gang Qing, Yu Sun, Ning Li, Yue Hou
Summary: The study explored the effect of kellerin on cerebral ischemia and its possible mechanisms using MCAO model and LPS-activated microglia model. Kellerin improved neurological outcome, reduced brain infarct size, and alleviated neuron damage by inhibiting microglial activation under pathologic conditions of focal cerebral ischemia. In in vitro studies, kellerin protected neuronal cells from damage by suppressing pro-inflammatory cytokines, NF-kappa B signaling pathway, ROS generation, and NADPH oxidase activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Xu Wendeng, Gao Ceshu, Wu Jian
Summary: CD151 overexpression protects BBB permeability in the early phase after transient focal cerebral ischemia, demonstrating its potential as a target for early BBB protection in ischemic stroke.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ilaria Dettori, Lisa Gaviano, Filippo Ugolini, Daniele Lana, Irene Bulli, Giada Magni, Francesca Rossi, Maria Grazia Giovannini, Felicita Pedata
Summary: This study demonstrates that stimulation of A(2B) receptors can attenuate neuroinflammation that develops after ischemia, indicating that A(2B) receptors may be a new interesting pharmacological target for protecting against degeneration following brain ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yujiao Lu, Jing Wang, Fulei Tang, Uday P. Pratap, Gangadhara R. Sareddy, Krishnan M. Dhandapani, Ana Capuano, Zoe Arvanitakis, Ratna K. Vadlamudi, Darrell W. Brann
Summary: Hemoglobin plays an important role in regulating neuronal oxygenation and neuroprotection. The levels of neuronal hemoglobin decrease with age in mice, leading to increased hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ryley D. McClelland, Tyce N. Culp, David J. Marchant
Summary: Viruses use host factors to enter cells and cause disease, and imaging techniques are crucial for studying virus entry and replication processes, providing insights into viral infection mechanisms. Quantifying viral images and using cryo-electron microscopy to gather structural information of viruses can help identify novel targets for antiviral therapeutics and vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
John W. Constantakis, Catherine A. Reed-McBain, Bolanle Famakin
Summary: Astrocytes are glial cells that play important roles in the healthy brain, including maintaining the blood brain barrier, modulating synaptic transmission and neuronal plasticity, and forming glial scars following ischemic injury. Following ischemia, astrocytes undergo specific changes in phenotype and gene expression, contributing to both the propagation and amelioration of neuronal injury. This review focuses on the dual role of astrocytes and the innate immune system in amplifying secondary brain injury and attenuating ischemic damage, discussing potential molecular signaling and processes that could be targeted for therapeutic interventions.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Immunology
Raffaella Morini, Matteo Bizzotto, Fabio Perrucci, Fabia Filipello, Michela Matteoli
Summary: The role of microglia in controlling synapse homeostasis is increasingly recognized by the scientific community, with potential therapeutic implications in conditions like schizophrenia and Alzheimer's Disease. Methodological approaches to investigate microglial synaptic engulfment include various in vitro assays and co-cultures of microglia and neurons, requiring further validation in mice brain for representative in vivo results. This review aims to analyze the technical approaches to studying microglia-mediated phagocytosis of neuronal and synaptic substrates in critical developmental time windows.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Masayo Koide, Hannah R. Ferris, Mark T. Nelson, George C. Wellman
Summary: Subarachnoid hemorrhage (SAH) is a common form of hemorrhagic stroke with high mortality and severe disability rates. Recent studies suggest that delayed cerebral ischemia (DCI) in SAH is related to disturbances in cerebral circulation, particularly involving cerebral autoregulation malfunction. The study quantitatively examines the impact of SAH on cerebral autoregulation and provides evidence of decreased cerebral blood flow and impaired autoregulation range in SAH animals. This novel methodology could lead to future studies on therapeutic strategies targeting impaired cerebral autoregulation in cardiovascular and cerebrovascular disorders.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Floran Begue, Sebastien Tanaka, Zarouki Mouktadi, Philippe Rondeau, Bryan Veeren, Nicolas Diotel, Alexy Tran-Dinh, Tiphaine Robert, Erick Velia, Patrick Mavingui, Marie Lagrange-Xelot, Philippe Montravers, David Couret, Olivier Meilhac
Summary: The study showed significant changes in HDL proteome and decreased functionality in severe COVID-19 patients.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Sebastien Tanaka, Jules Stern, Donia Bouzid, Tiphaine Robert, Monique Dehoux, Aurelie Snauwaert, Nathalie Zappella, Maxime Cournot, Brice Lortat-Jacob, Pascal Augustin, Enora Atchade, Alexy Tran-Dinh, Olivier Meilhac, Philippe Montravers
Summary: The study identified changes in HDL and LDL concentrations in septic patients over time, with significant differences between survivors and nonsurvivors. Specific levels of lipoprotein concentrations were associated with short-term and long-term prognostic outcomes in patients.
ANNALS OF INTENSIVE CARE
(2021)
Article
Multidisciplinary Sciences
Stephane Marot, Isabelle Malet, Valentin Leducq, Karen Zafilaza, Delphine Sterlin, Delphine Planas, Adelie Gothland, Aude Jary, Karim Dorgham, Timothee Bruel, Sonia Burrel, David Boutolleau, Olivier Schwartz, Guy Gorochov, Vincent Calvez, Anne-Genevieve Marcelin
Summary: This study found that SARS-CoV-2 infection can induce neutralizing antibody response correlated with antibody levels, but this neutralizing activity declines after two months post-disease onset, suggesting the need for maintaining infection prevention measures and considering periodic vaccination boosts.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Michael Thy, Sebastien Tanaka, Alexy Tran-Dinh, Lara Ribeiro, Brice Lortat-Jacob, Julia Donadio, Nathalie Zappella, Mouna Ben-Rehouma, Parvine Tashk, Aurelie Snauwaert, Enora Atchade, Nathalie Grall, Philippe Montravers
Summary: Emergence of microorganisms, including MDR bacteria, is frequently noted in NSTI without affecting mortality.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Naouale Maataoui, Lotfi Chemali, Juliette Patrier, Alexy Tran Dinh, Lucie Le Fevre, Brice Lortat-Jacob, Mehdi Marzouk, Camille d'Humieres, Emilie Rondinaud, Etienne Ruppe, Philippe Montravers, Jean-Francois Timsit, Laurence Armand-Lefevre
Summary: This study evaluated the performance and impact of the BioFire® FilmArray® Pneumonia plus Panel in COVID-19 ICU patients, demonstrating its potential role in improving antibiotic stewardship by facilitating timely administration of appropriate antibiotics and avoiding unnecessary prescriptions.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Geoffroy Vellieux, Helene Amiel, Caroline Roos, Isabelle Crassard, Emmanuel Houdart, Nathalie Kubis, Pierre Lozeron
Summary: The study found that migraine with aura presents distinctive EEG relative power compared to other transient neurological deficits. Further research on the diagnostic value of EEG in other TND is suggested, especially within the first 24 hours of symptom onset.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Camille d'Humieres, Juliette Patrier, Brice Lortat-Jacob, Alexy Tran-dinh, Lotfi Chemali, Naouale Maataoui, Emilie Rondinaud, Etienne Ruppe, Charles Burdet, Stephane Ruckly, Philippe Montravers, Jean-Francois Timsit, Laurence Armand-Lefevre
Summary: Among 197 COVID-19 patients hospitalized in ICU, 44.7% experienced bacterial infections, with pneumonia and bloodstream infections being the most frequent. Unusual findings include suspected bacterial translocations from the digestive tract and bacterial persistence in the lungs despite adequate therapy.
Article
Critical Care Medicine
Cyril Touchard, Jerome Cartailler, Geoffroy Vellieux, Etienne de Montmollin, Pierre Jaquet, Ruben Wanono, Jean Reuter, Marylou Para, Lila Bouadma, Jean-Francois Timsit, Marie-Pia d'Ortho, Nathalie Kubis, Anny Rouvel Tallec, Romain Sonneville
Summary: In adult patients under VA-ECMO, a simplified 4-frontal electrode EEG montage interpreted by an intensivist, detected common EEG patterns associated with poor outcomes, with a performance similar to that of a standard EEG montage interpreted by expert neurophysiologists.
ANNALS OF INTENSIVE CARE
(2021)
Article
Physiology
Matthias Barral, Imane El-Sanharawi, Anthony Dohan, Maxime Sebuhyan, Alexis Guedon, Audrey Delarue, Alexandre Boutigny, Nassim Mohamedi, Benjamin Magnan, Salim Kemel, Chahinez Ketfi, Nathalie Kubis, Annouk Bisdorff-Bresson, Marc Pocard, Philippe Bonnin
Summary: In tumors with angiogenesis, increased blood flow leads to arterial remodeling to normalize flow velocities and shear stress. Changes in flow velocities and shear stress can reflect disease progression during tumor expansion, while measurements of blood flow and shear stress can help assess the condition in certain diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Infectious Diseases
Sebastien Tanaka, Michael Thy, Parvine Tashk, Lara Ribeiro, Brice Lortat-Jacob, Jean-Francois Hermieu, Nathalie Zappella, Sacha Rozencwajg, Aurelie Snauwaert, Enora Atchade, Nathalie Grall, Maksud Assadi, Alexy Tran-Dinh, Philippe Montravers
Summary: In a population of severe ICU NSTI patients, antibiotic exposure before sampling did not impact either culture sample positivity or microbiological findings.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Neurosciences
Adrien Cogo, Gabrielle Mangin, Sarah Mouazan, Tatiana Merkulova-Rainon, Jean-Pierre Riveline, Jean-Francois Gautier, Mathilde Varret, Nathalie Kubis
Summary: Transplantation of peripheral blood mononuclear cells was found to alleviate neurological deficits, reduce infarct volume, and apoptosis in post-stroke diabetic mice. However, the prevention effect on long-term memory loss was limited, and the impact of diabetes on cell therapy efficacy needs further investigation in future studies.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Anesthesiology
Stefan Andrei, Elie Kantor, Maksud Asssadi, Anne Boutten, Quentin Pellenc, Gilles Jebrak, Mathieu Godement, Samia Abbas, Enora Atchade, Alexy Tran-Dinh, Tiphaine Robert-Mercier, Liana Valeanu, Dan Longrois, Philippe Montravers, Pascal Augustin
Summary: This study aimed to evaluate the association between early postoperative troponin concentration and 1-year mortality after lung transplantation. The results showed that early postoperative troponin levels were correlated to bilateral lung transplantation, the need for extracorporeal life support, and intraoperative blood transfusion. However, they were not independently associated with 1-year mortality.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Clinical Neurology
Edouard Berling, Guillaume Fargeot, Karine Aure, Tuan Huy Tran, Nathalie Kubis, Pierre Lozeron, Adrien Zanin
Summary: Recreational nitrous oxide abuse can lead to severe motor neuropathy and ataxia in young patients, with elevated homocysteine levels and normal cobalamin levels. Despite vitamin B12 supplementation, symptoms may only partially resolve, highlighting the need for long-term follow-up to assess the severity of these toxic neuropathies.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Marine Peyneau, Vanessa Granger, Paul-Henri Wicky, Dounia Khelifi-Touhami, Jean-Francois Timsit, Francois-Xavier Lescure, Yazdan Yazdanpanah, Alexy Tran-Dinh, Philippe Montravers, Renato C. Monteiro, Sylvie Chollet-Martin, Margarita Hurtado-Nedelec, Luc de Chaisemartin
Summary: This study investigated the correlation between circulating innate phagocytes and disease severity in COVID-19 patients. The results showed abnormal phenotype of neutrophils and monocytes, elevated concentrations of activation markers in plasma. Critical patients exhibited increased immature and immunosuppressive neutrophils, downregulated HLA-DR monocytes, which were closely associated with disease severity. Additionally, impaired antimicrobial functions in neutrophils and monocytes of critical patients were correlated with organ dysfunction, severe infections, and mortality.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Philippe Bonnin, Nathalie Kubis, Christiane Charriaut-Marlangue
Summary: Enhancing collateral blood supply during acute cerebral ischemia can limit infarct extension and reduce disability. Differences in collateral blood flow establishment time may vary between species and genetic backgrounds. Caution should be taken when translating preclinical findings to humans, and clinical trials are necessary to validate the added value of pharmacological agents for stimulating collateral blood supply.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.