Article
Biochemistry & Molecular Biology
K. C. Elina, Hyeong Cheol Moon, Jaisan Islam, Hyong Kyu Kim, Young Seok Park
Summary: Research has shown that optogenetic inhibition of the ACC can improve neuropathic pain caused by nerve injury and has a significant analgesic effect on mechanical and thermal sensitivity. The study also found that hyperactivity of the ACC in nerve injury may affect output to the spinothalamic tract through direct or indirect pathways.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Norbert Hogrefe, Sigrid M. Blom, Kristina Valentinova, Niels R. Ntamati, Lotte J. E. Jonker, Natalie E. Nevian, Thomas Nevian
Summary: Malfunctioning synaptic plasticity is a major mechanism in the development of chronic pain. This study shows that even after recovery, the impact of chronic compression injury on synaptic plasticity persists.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Mario A. Acuna, Fernando Kasanetz, Paolo De Luna, Marta Falkowska, Thomas Nevian
Summary: The perception of pain is a complex experience and understanding how the brain distinguishes pain from other sensory stimuli has been a challenge. In this study, researchers used calcium imaging in mice to investigate the coding of pain in the anterior cingulate cortex. They found that population activity, rather than single-cell responses, allowed the discrimination of painful stimuli. Additionally, they discovered that chronic neuropathic pain led to changes in sensory processing, which were restored by analgesic treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Qiao-Yun Li, Shao-Xia Chen, Jin-Yu Liu, Pei-Wen Yao, Yi-Wen Duan, Yong-Yong Li, Ying Zang
Summary: In this study, the neuroimmune changes in bilateral ACC region were investigated and compared using unilateral- and mirror-pain models. It was found that CX3CL1 plays a pivotal role in the descending facilitation function, leading to enhanced pain sensitization and mirror-image pain.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Ming Zhang, Ziyan Yang, Jiahui Zhong, Yuqi Zhang, Xiaomin Lin, Huajian Cai, Yazhuo Kong
Summary: Nostalgia, as a positive emotion, has an analgesic effect and may modulate brain activity to reduce pain perception.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Elsa Cortes-Montero, Maria Rodriguez-Munoz, M. Carmen Ruiz-Cantero, Enrique J. Cobos, Pilar Sanchez-Blazquez, Javier Garzon-Nino
Summary: TRPA1 channels are involved in nociceptive signaling, forming functional associations with MORs and NMDARs to promote pain transmission and modulate analgesic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Steliana Yanakieva, Mathias L. Mathiasen, Eman Amin, Andrew J. D. Nelson, Shane M. O'Mara, John P. Aggleton
Summary: This study compared collateral projections from different rostral thalamic nuclei terminating in different cortical areas. The results showed that these projections predominantly arise from separate populations of neurons with discrete cortical termination zones.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jing Wen, Yaowei Xu, Zhixiang Yu, Yifan Zhou, Wenting Wang, Jingjie Yang, Yiming Wang, Qian Bai, Zhisong Li
Summary: Neuropathic pain is often accompanied by anxiety and depression-like manifestations. Changes in synaptic plasticity in the anterior cingulate cortex (ACC) play a crucial role, but the mechanisms are unclear. The activation of the CREB/BDNF pathway in the spinal cord and ACC is involved in the development of neuropathic pain and related anxiety and depression. Targeting CREB/BDNF in the ACC shows promise as a therapeutic approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yiwen Duan, Qiaoyun Li, Yaohui Zhou, Shaoxia Chen, Yongyong Li, Ying Zang
Summary: The hyperexcitability of the anterior cingulate cortex (ACC) is associated with the development of chronic pain. Disinhibition of the ACC, which may be caused by dysfunction of inhibitory parvalbumin (PV)-expressing interneurons (PV-INs), is one of the key factors contributing to ACC hyperexcitation. However, the molecular mechanism underlying ACC PV-INs injury is still unclear. This study demonstrates that nerve injury induces an imbalance in the excitatory and inhibitory activity of the ACC. The upregulation of tumor necrosis factor-alpha (TNF-alpha) in the ACC after nerve injury activates necroptosis and contributes to PV-INs damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Yao Q. Wang, Junshi Wang, Sun-hui Xia, Howard B. Gutstein, Yanhua H. Huang, Oliver M. Schluter, Jun-Li Cao, Yan Dong
Summary: The study revealed that pain experience can induce remodeling of neural circuits between the mediodorsal thalamus and the anterior cingulate cortex, leading to the generation of silent synapses that contribute to allodynia and hyperalgesia. These silent synapses undergo changes over time post-pain experience, affecting pain sensitivity.
Article
Neurosciences
Volker Neugebauer, Peyton Presto, Vadim Yakhnitsa, Nico Antenucci, Brianna Mendoza, Guangchen Ji
Summary: Neuroplasticity in cortico-limbic circuits is important in pain persistence and modulation. The amygdala plays a key role in the emotional dimension of pain, and interactions with prefrontal cortical regions change in pain conditions. Other regions in the limbic system are also involved in pain modulation. The corticolimbic system contains opioids and opioid receptors, and their modulatory effects and potential opposing functions are still not fully understood.
Article
Anesthesiology
Haifeng Duan, Fengyan Shen, Li Li, Zhiyi Tu, Ping Chen, Pei Chen, Zhiru Wang, Weimin Liang, Yingwei Wang
Summary: The activation of the Notch/Hes1 signaling pathway in the ACC plays a crucial role in the development of neuropathic pain, while Hes5 is not involved in this process. Therefore, the Notch pathway may represent a novel therapeutic target for treating chronic pain.
Article
Behavioral Sciences
Marta Falkowska, Niels R. Ntamati, Natalie E. Nevian, Thomas Nevian, Mario A. Acuna
Summary: Depression is often seen in patients with chronic pain, but there is a lack of effective pharmacological treatments. Environmental enrichment has been suggested as an alternative approach to alleviate pain-induced depression, but its underlying mechanisms are still unclear. The anterior cingulate cortex (ACC) plays a crucial role in processing pain-related negative emotions and plasticity in this region is associated with depressive symptoms. This study investigated the effects of different durations of environmental enrichment on pain sensitivity and depression-like behaviors in a mouse model of neuropathic pain. We also examined the electrophysiological properties of pyramidal neurons in the ACC and correlated them with behavioral outcomes. The findings showed that early exposure to an enriched environment alone did not prevent the development of pain-induced depression-like symptoms. However, extending the enrichment after injury prevented depression and reduced mechanical hypersensitivity. Increased neuronal excitability in the ACC was associated with the depressive phenotype, which was reversed by the environmental enrichment. These results suggest that improving environmental factors can enhance resilience to chronic pain-related depression and support the use of non-pharmacological interventions as potential treatment strategies.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Yu Zhang, Shiwei Jiang, Fei Liao, Zhifeng Huang, Xin Yang, Yu Zou, Xin He, Qulian Guo, Changsheng Huang
Summary: The study investigates transcriptomic profiles of the anterior cingulate cortex (ACC) in a rat chronic constriction injury (CCI) model, suggesting that chemokines and their targeting genes may play different roles in the development of neuropathic pain. These findings are important for understanding the mechanisms of pain emotion and developing potential treatments.
Article
Neurosciences
Xiao Zhang, Peng Liu, Xiaolan He, Zhenhua Jiang, Qun Wang, Nan Gu, Yan Lu
Summary: The study found that PKC gamma neurons in the ACC are closely linked to neuropathic allodynia and pain-related emotional behaviors, affecting mechanical allodynia and emotional responses.
Article
Chemistry, Organic
Jiaan Shao, Richard A. Houghten, Colette T. Dooley, Margret Cazares, Jay P. McLaughlin, Shainnel O. Eans, Michelle L. Ganno, Michelle R. Hoot, Marc A. Giulianotti, Yongping Yu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Critical Care Medicine
Douglas F. Willson, Michelle Hoot, Robinder Khemani, Christopher Carrol, Aileen Kirby, Adam Schwarz, Rainer Gedeit, Sholeen T. Nett, Simon Erickson, Heidi Flori, Spencer Hays, Mark Hall
PEDIATRIC CRITICAL CARE MEDICINE
(2017)
Article
Neurosciences
Michelle R. Hoot, Harvey S. Levin, Austin N. Smith, Gary Goldberg, Elisabeth A. Wilde, William C. Walker, Blessen C. Eapen, T. Nolen, N. L. Pugh
Article
Behavioral Sciences
Michelle R. Hoot, Elizabeth I. Sypek, Kate J. Reilley, Amanda N. Carey, Jean M. Bidlack, Jay P. McLaughlin
BEHAVIOURAL PHARMACOLOGY
(2013)
Article
Neurosciences
Michelle R. Hoot, Laura J. Sim-Selley, Justin L. Poklis, Rehab A. Abdullah, Krista L. Scoggins, Dana E. Selley, William L. Dewey
Article
Anesthesiology
Patrick C. Carroll, Carlton Haywood, Michelle R. Hoot, Sophie Lanzkron
CLINICAL JOURNAL OF PAIN
(2013)
Article
Chemistry, Applied
Christopher J. Armishaw, Jayati Banerjee, Michelle L. Ganno, Kate J. Reilley, Shainnel O. Eans, Elisa Mizrachi, Reena Gyanda, Michelle R. Hoot, Richard A. Houghten, Jay P. McLaughlin
ACS COMBINATORIAL SCIENCE
(2013)
Article
Medicine, General & Internal
Michelle R. Hoot, Bilal Khokhar, William C. Walker
Review
Neurosciences
SE Harte, MR Hoot, GS Borszcz
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.