Review
Cell Biology
Jee-San Lee, Nathalie Lamarche-Vane, Stephane Richard
Summary: Microexons are small-sized exons that undergo extensive alternative splicing, especially in neurons, microglia, embryonic stem cells, and cancer cells. Including microexons within mRNAs has significant functional consequences in the central nervous system, with dysregulation of their inclusion leading to abnormal processes. The involvement of RNA binding proteins in regulating the inclusion and exclusion of microexons during splicing is crucial for cellular physiology, especially in CNS diseases.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Review
Biochemical Research Methods
Jiashu Liu, Cui-Xiang Lin, Xiaoqi Zhang, Zongxuan Li, Wenkui Huang, Jin Liu, Yuanfang Guan, Hong-Dong Li
Summary: Alternative splicing (AS), a key pathway for transcriptional regulation, has been shown to be associated with complex diseases. Computational approaches for detecting disease-associated AS events have been developed. This review discusses the metrics used for characterizing AS events quantitatively. It also reviews and discusses three types of methods for detecting disease-associated splicing events: differential splicing analysis, aberrant splicing detection, and splicing-related network analysis. Additionally, methods for detecting genetic variants that potentially regulate splicing are described. Experimental comparisons are conducted to illustrate the performance of each method. The limitations of these methods are discussed, as well as potential ways to address them. This review aims to provide a systematic understanding of computational approaches for analyzing disease-associated splicing.
BRIEFINGS IN BIOINFORMATICS
(2023)
Review
Agriculture, Multidisciplinary
Xin Qu, Lijuan Zhang, Lin Wang
Summary: This review summarizes the protective mechanisms of pterostilbene in CNS disorders, including antioxidant and anti-inflammatory activity, regulation of lipid metabolism and vascular smooth muscle cell proliferation, improvement of synaptic function and neurogenesis, induction of glioma cell cycle arrest, and inhibition of glioma cell migration and invasion. Molecular targets and pathways for the protective actions of pterostilbene are discussed, and future studies should focus on animal models and human studies to further evaluate its role and mechanisms in CNS disorders.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Ke Chen, Si Sun, Junying Wang, Xiao-Dong Zhang
Summary: The central nervous system is crucial for human health, and the treatment of CNS diseases is essential. Artificial enzymes offer high stability and catalytic activity, showing great potential for treating neuroinflammation and other disorders.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Endocrinology & Metabolism
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster
Summary: Alternative RNA splicing is an important biological process that has been linked to various clinical syndromes, but its applicability to common diseases is still uncertain. This review focuses on the changes in alternative RNA splicing in fatty liver disease and the role of splicing regulation in disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Santhosh Sethuramanujam, Akihiro Matsumoto, Geoff deRosenroll, Benjamin Murphy-Baum, J. Michael McIntosh, Miao Jing, Yulong Li, David Berson, Keisuke Yonehara, Gautam B. Awatramani
Summary: The study reveals that acetylcholine signals are transmitted through a rapid co-activation mechanism, activating receptors on multiple neurons surrounding the release site. Additionally, while acetylcholine signals are direction-selective locally, they do not show global directionality, facilitating information transfer at a local scale.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Wenjie Zhang, Yuan Chen, Hui Pei
Summary: C1q is an essential component of the complement system, performing non-specific immune functions and playing a crucial role in immune homeostasis and normal physiological functions. In the developing central nervous system, C1q is involved in synapse formation, pruning, and the development of neuronal networks. C1q has a close relationship with microglia and astrocytes and may contribute to the development of CNS disorders. Clinical trials are already underway for CNS disorders, highlighting the potential therapeutic target of C1q.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte
Summary: Alternative RNA splicing is an essential physiological function that plays a crucial role in cellular development. RNA splicing dysfunction has been implicated in the development of several cancers, including myeloid malignancies. Cancer cells exhibit marked gene expression alterations, including different usage of AS isoforms, potentially causing tissue-specific effects and disruptions of downstream pathways.
Review
Biochemistry & Molecular Biology
Bowen Jia, Jing Li, Yiting Song, Chengliang Luo
Summary: Ferroptosis is a form of iron-dependent regulated cell death characterized by iron-dependent lipid peroxidation and has been implicated in various diseases, including nervous system diseases and injuries. ACSL4, a member of the ACSLs family, is involved in the regulation of arachidonic acid and eicosapentaenoic acid, leading to ferroptosis. Understanding the molecular mechanisms of ACSL4-mediated ferroptosis will contribute to the development of new treatment strategies for these diseases or injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Benedetta Russo, Marika Menduni, Patrizia Borboni, Fabiana Picconi, Simona Frontoni
Summary: This review discusses the role of the autonomic nervous system in obesity and insulin-resistance, highlighting the bi-directional effects of related mechanisms, and exploring the neural, hormonal, and nutritional mechanisms involved. Leptin is emphasized for its crucial role in appetite regulation, glucose homeostasis, and energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhongwu Guo
Summary: GM1 is a major glycosphingolipid on the cell surface in the CNS with a wide range of functions, including cell differentiation, neuritogenesis, signal transduction, memory, and cognition. GM1 is also involved in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and may have therapeutic applications in these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Shuyu Shi, Hongze Ren, Yujie Xie, Meihua Yu, Yu Chen, Liqun Yang
Summary: This article provides an overview of advanced nanoengineering technologies for the delivery of neurotherapeutics, explaining how nanotherapeutics overcome the blood-brain barriers for enhanced therapeutic effects in CNS diseases. It discusses typical paradigms of nanomaterials and their impacts on the treatment of central nervous system disorders.
Review
Biochemistry & Molecular Biology
Dominique Figarella-Branger, Carole Colin, Nathalie Baeza-Kallee, Aurelie Tchoghandjian
Summary: This review focuses on the expression of A2B5 in the central nervous system and gliomas. A2B5 is found in neural stem cells during brain development and in neurogenic areas and white matter in adults, where it identifies oligodendrocyte precursor cells and cells with neural stem cell properties. A2B5 has been identified as an accurate marker to identify glioma cancer stem cells and its expression is positively correlated with stemness and tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Anthony J. Murphy, Alex H. Li, Peichao Li, Hong Sun
Summary: Alternative splicing plays a crucial role in diversifying the proteome and has significant implications in cancer development. Recent studies have highlighted the important roles of SR proteins in cancer progression. Understanding the spliceosome and its relationship to cancer has opened up new opportunities for therapeutic interventions based on alternative splicing.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Seong-Ki Lee, Walter F. Boron
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Genetics & Heredity
Chao Yuan, Tiantian Han, Pan Su, Min Liu, Xiaopei Zhou, Dazhi Zhang, Weimin Jia, Ali Wang, Min Yue, Zibing Xiang, Liming Chen, Xianqin Zhang
OPHTHALMIC GENETICS
(2018)
Article
Physiology
Zhang-Dong Xie, Yi-Min Guo, Mei-Juan Ren, Jichun Yang, Shao-Fang Wang, Tong-Hui Xu, Li-Ming Chen, Ying Liu
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Physiology
Jin-Lin Wang, Lei Zhao, Jun Zhu, Deng-Ke Wang, Mei-Juan Ren, Meng Wang, Ying Liu, Walter F. Boron, Li-Ming Chen
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Neurosciences
Jin-Lin Wang, Xiao-Yu Wang, Deng-Ke Wang, Mark D. Parker, Raif Musa-Aziz, Jacob Popple, Yi-Min Guo, Tian-Xin Min, Tian Xia, Min Tan, Ying Liu, Walter F. Boron, Li-Ming Chen
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Biochemistry & Molecular Biology
Meng Wang, Han Wu, Ying Liu, Li-Ming Chen
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Neurosciences
Fraser J. Moss, Walter F. Boron
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Neurosciences
Pan Su, Han Wu, Meng Wang, Lu Cai, Ying Liu, Li-Ming Chen
Summary: The electrogenic Na+/HCO3- cotransporter NBCe1-B is widely expressed in various tissues in the body and is mainly restricted by self-inhibition, but can be activated by interaction with IRBIT protein. This study elucidates the molecular mechanisms of self-inhibition and IRBIT activation of NBCe1-B.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Han Wu, Shiyong Liu, Pan Su, Zhang-Dong Xie, Tian-Xiang Gui, Lei Zhao, Ying Liu, Li-Ming Chen
Summary: The secondary active transporter NBCe1 couples the transmembrane movement of Na+ and carbonate species in different modes. The study reveals that the substrate-binding kinetics of NBCe1 is distinct from other transporters, with HCO3- binding preceding Na+ binding.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Cell Biology
Lili Chen, Yuting Liu, Pan Su, Wesley Hung, Haiwen Li, Ya Wang, Zhongpu Yue, Ming-Hai Ge, Zheng-Xing Wu, Yan Zhang, Peng Fei, Li-Ming Chen, Louis Tao, Heng Mao, Mei Zhen, Shangbang Gao
Summary: This study found that the neuropeptide NLP-18 and its receptor CKR-1 regulate an escape circuit to execute a full turn. NLP-18 activates CKR-1 in the gustatory sensory neuron to modulate the head motor neuron and the turn-initiating interneuron, resulting in robust escape steering. This discovery reveals the neural mechanism behind the regulation of escape behavior.
Article
Urology & Nephrology
Seong-Ki Lee, Rossana Occhipinti, Fraser J. Moss, Mark D. Parker, Irina I. Grichtchenko, Walter F. Boron
Summary: This study aims to differentiate the movements of HCO3 2, CO35, and H1 across membranes. Through electrophysiology and heterologous expression in Xenopus oocytes, the researchers investigated the transport of bicarbonate (HCO32) by SLC4 family members. The results showed that the Cl-HCO3 exchanger AE1 (SLC4A1) can transport HCO32, while the electrogenic Na/HCO3 cotransporter NBCe1 (SLC4A4) and the electroneutral Na1-driven Cl-HCO3 exchanger NDCBE (SLC4A8) cannot. Mathematical simulations further supported CO35 transport as the mechanism for NBCe1.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Physiology
Lu Cai, Dengke Wang, Tianxiang Gui, Xiaoyu Wang, Lingyu Zhao, Walter F. Boron, Li-Ming Chen, Ying Liu
Summary: The kidney is essential for maintaining fluid and electrolyte balance. NBCn1, NBCn2, AE2, IRBITs, and PP1 are critical regulators in sodium handling in the kidney. Our study provides evidence that IRBITs and PP1 stimulate the activity of NBCn1, NBCn2, and AE2 to inhibit sodium reabsorption, contributing to sodium homeostasis in the body.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Seong-Ki Lee, Walter F. Boron, Rossana Occhipinti
Summary: Carbonic anhydrases (CAs) are essential for physiological processes due to their role in catalyzing the conversion of CO2 and water to bicarbonate and protons, impacting pH levels. In the kidneys, CAs and HCO3- transporters, specifically the NCBTs and AEs, play significant roles in urinary acid secretion, particularly HCO3- reabsorption. Recent findings suggest that NCBTs transport CO32- instead of HCO3-, suggesting a revised understanding of their function. This review examines the role of CAs and HCO3- transporters in renal acid-base physiology and discusses the implications of novel findings on HCO3- reabsorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Weili Yang, Junpei Wang, Zhenzhen Chen, Ji Chen, Yuhong Meng, Liming Chen, Yongsheng Chang, Bin Geng, Libo Sun, Lin Dou, Jian Li, Youfei Guan, Qinghua Cui, Jichun Yang
Article
Endocrinology & Metabolism
Zhenzhen Chen, Liwei Ding, Weili Yang, Junpei Wang, Liming Chen, Yongsheng Chang, Bin Geng, Qinghua Cui, Youfei Guan, Jichun Yang
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
